Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia.

Autor: Liang Z; Chinese Academy for Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK. Electronic address: zhu.liang@ndm.ox.ac.uk., Damianou A; Chinese Academy for Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK., Vendrell I; Chinese Academy for Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK., Jenkins E; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK., Lassen FH; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford OX3 7LF, UK., Washer SJ; James and Lillian Martin Centre for Stem Cell Research, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK., Grigoriou A; Chinese Academy for Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK., Liu G; Chinese Academy for Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK., Yi G; Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Lou H; Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK., Cao F; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UK., Zheng X; Chinese Academy for Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK., Fernandes RA; Chinese Academy for Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK., Dong T; Chinese Academy for Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK., Tate EW; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UK., Di Daniel E; Alzheimer's Research UK Oxford Drug Discovery Institute, University of Oxford, Oxford OX3 7FZ, UK., Kessler BM; Chinese Academy for Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK. Electronic address: benedikt.kessler@ndm.ox.ac.uk.

Publikováno v: Cell reports [Cell Rep] 2024 May 28; Vol. 43 (5), pp. 114152. Date of Electronic Publication: 2024 Apr 25.

Functional characterization of the schizophrenia associated gene AS3MT identifies a role in neuronal development.

Autor: Washer SJ; University of Exeter College of Medicine and Health, University of Exeter, Exeter, UK.; Cellular Operations, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Flynn R; University of Exeter College of Medicine and Health, University of Exeter, Exeter, UK., Oguro-Ando A; University of Exeter College of Medicine and Health, University of Exeter, Exeter, UK., Hannon E; University of Exeter College of Medicine and Health, University of Exeter, Exeter, UK., Burrage J; University of Exeter College of Medicine and Health, University of Exeter, Exeter, UK., Jeffries A; University of Exeter College of Medicine and Health, University of Exeter, Exeter, UK., Mill J; University of Exeter College of Medicine and Health, University of Exeter, Exeter, UK., Dempster EL; University of Exeter College of Medicine and Health, University of Exeter, Exeter, UK.

Publikováno v: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics [Am J Med Genet B Neuropsychiatr Genet] 2022 Jul; Vol. 189 (5), pp. 151-162. Date of Electronic Publication: 2022 Jun 19.

Attenuated Induction of the Unfolded Protein Response in Adult Human Primary Astrocytes in Response to Recurrent Low Glucose.

Autor: Weightman Potter PG; Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, United Kingdom., Washer SJ; Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, United Kingdom., Jeffries AR; Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, United Kingdom., Holley JE; Royal Devon and Exeter Hospital, University of Exeter Medical School and the Department of Neurology, Exeter, United Kingdom., Gutowski NJ; Royal Devon and Exeter Hospital, University of Exeter Medical School and the Department of Neurology, Exeter, United Kingdom., Dempster EL; Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, United Kingdom., Beall C; Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, United Kingdom.

Publikováno v: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2021 May 26; Vol. 12, pp. 671724. Date of Electronic Publication: 2021 May 26 (Print Publication: 2021).