Drug dependence in cancer is exploitable by optimally constructed treatment holidays.

Autor: Maltas, Jeff, Killarney, Shane T., Singleton, Katherine R., Strobl, Maximilian A. R., Washart, Rachel, Wood, Kris C., Wood, Kevin B.

Publikováno v: Nature Ecology & Evolution; Jan2024, Vol. 8 Issue 1, p147-162, 16p

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PKN2 is a dependency of the mesenchymal-like cancer cell state.

Autor: Killarney ST; Duke University, Durham, NC, United States., Mesa G; Duke University, Durham, NC, United States., Washart R; Duke University., Mayro B; The University of Texas Southwestern Medical Center, United States., Dillon K; Duke University, Durham, NC, United States., Wardell SE; Duke University, Durham, NC, United States., Newlin M; Duke University, Durham, NC, United States., Lu M; Duke University, Durham, NC, United States., Abu Rmaileh A; Duke University, Durham, North Carolina, United States., Liu N; Harvard University, Cambridge, MA, United States., McDonnell DP; Duke University, Durham, NC, United States., Pendergast AM; Duke University, Durham, NC, United States., Wood KC; Duke University, Durham, NC, United States.

Publikováno v: Cancer discovery [Cancer Discov] 2024 Nov 19. Date of Electronic Publication: 2024 Nov 19.