Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Waseem, Qasim"'
Autor:
Christos Georgiadis, Lauren Nickolay, Farhatullah Syed, Hong Zhan, Soragia Athina Gkazi, Annie Etuk, Ulrike Abramowski-Mock, Roland Preece, Piotr Cuber, Stuart Adams, Giorgio Ottaviano, Waseem Qasim
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Umbilical cord blood (UCB) T cells exhibit distinct naive ontogenetic profiles and may be an attractive source of starting cells for the production of chimeric antigen receptor (CAR) T cells. Pre-selection of UCB-T cells on the basis of CD62L express
Externí odkaz:
https://doaj.org/article/cdb82ae8baf04b8389ea2a1288375c7b
Autor:
Avijeet Kumar Mishra, Waseem Qasim
Publikováno v:
EJC Paediatric Oncology, Vol 3, Iss , Pp 100149- (2024)
Autologous chimeric antigen receptor (CAR) T cell therapy has revolutionised the management of certain B-cell malignancies. However, as bespoke therapies, challenges include complex manufacturing logistics and risks ranging from suboptimal harvests t
Externí odkaz:
https://doaj.org/article/3b24bea66be0487b94d4b6371d83a5c1
Autor:
Gaetano Naso, Soragia Athina Gkazi, Christos Georgiadis, Vignesh Jayarajan, Joanna Jacków, Roland Fleck, Leanne Allison, Olumide Kayode Ogunbiyi, John Alexander McGrath, Dusko Ilic, Wei-Li Di, Anastasia Petrova, Waseem Qasim
Publikováno v:
JID Innovations, Vol 3, Iss 3, Pp 100191- (2023)
Recessive dystrophic epidermolysis bullosa is a debilitating blistering skin disorder caused by loss-of-function mutations in COL7A1, which encodes type VII collagen, the main component of anchoring fibrils at the dermal−epidermal junction. Althoug
Externí odkaz:
https://doaj.org/article/9263ccbe4af242a788d4bbea877e0263
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Penetration enhancement of metformin hydrochloride via its molecular dispersion in sorbitan monostearate microparticles is reported. This represents basic philosophy to maximize its entrapment for maximum penetration effect. Drug dispersion
Externí odkaz:
https://doaj.org/article/c0b4bbd91dd94b5cbf04f76b7b04e6bb
Autor:
Roland Preece, Andrea Pavesi, Soragia Athina Gkazi, Kerstin A. Stegmann, Christos Georgiadis, Zhi Ming Tan, Jia Ying Joey Aw, Mala K. Maini, Antonio Bertoletti, Waseem Qasim
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 149-161 (2020)
Emerging base editing technology exploits CRISPR RNA-guided DNA modification effects for highly specific C > T conversion, which has been used to efficiently disrupt gene expression. These tools can enhance synthetic T cell immunity by restricting sp
Externí odkaz:
https://doaj.org/article/00ec11294bb54f618d18c76675005e30
Autor:
Carolina B. Ferreira, Rebecca P. Sumner, Maria T. Rodriguez-Plata, Jane Rasaiyaah, Richard S. Milne, Adrian J. Thrasher, Waseem Qasim, Greg J. Towers
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 209-219 (2020)
Most gene therapy lentiviral vector (LV) production platforms employ HEK293T cells expressing the oncogenic SV40 large T-antigen (TAg) that is thought to promote plasmid-mediated gene expression. Studies on other viral oncogenes suggest that TAg may
Externí odkaz:
https://doaj.org/article/5ec497afb24c436c8f1efc7f27c66a59
Autor:
Louise C. Gregory, Carolina B. Ferreira, Sara K. Young-Baird, Hywel J. Williams, Magdalena Harakalova, Gijs van Haaften, Sofia A. Rahman, Carles Gaston-Massuet, Daniel Kelberman, GOSgene, Waseem Qasim, Sally A. Camper, Thomas E. Dever, Pratik Shah, Iain C.A.F. Robinson, Mehul T. Dattani
Publikováno v:
EBioMedicine, Vol 42, Iss , Pp 470-480 (2019)
Background: The heterotrimeric GTP-binding protein eIF2 forms a ternary complex with initiator methionyl-tRNA and recruits it to the 40S ribosomal subunit for start codon selection and thereby initiates protein synthesis. Mutations in EIF2S3, encodin
Externí odkaz:
https://doaj.org/article/61da4410358e47e8afd4a94b157fdcae
Autor:
Prashant Hiwarkar, Mike Hubank, Waseem Qasim, Robert Chiesa, Kimberly C. Gilmour, Aurore Saudemont, Persis J. Amrolia, Paul Veys
Publikováno v:
Blood Advances, Vol 1, Iss 24, Pp 2206-2216 (2017)
Abstract: Omission of in vivo T-cell depletion promotes rapid, thymic-independent CD4+-biased T-cell recovery after cord blood transplant. This enhanced T-cell reconstitution differs from that seen after stem cell transplant from other stem cell sour
Externí odkaz:
https://doaj.org/article/0fb098107fff4d22ab1d0489bd849bdb
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Surfactants are well known as permeation enhancers. Span 60 microparticles encapsulating different concentrations of metformin HCl were prepared by using rapid congeal melting technique. Electro-scanning microscope showed smooth surface but less roun
Externí odkaz:
https://doaj.org/article/1088409f906f4e6585be66919b26f262
Autor:
Zainab M. Golwala, Nikita Gireesh Bhat, Jinhua Xu-Bayford, Tanja Stankova, Stuart Adams, Emma C. Morris, Waseem Qasim, Claire Booth, Austen Worth, Maaike A. Kusters, Reem Elfeky
Publikováno v:
Journal of Clinical Immunology.
Purpose There is a lack of data on post-HSCT non-osteopenic bone pathology specifically for children with inborn errors of immunity (IEI). We collected data on non-osteopenic bone pathology in children with IEI post-HSCT over two decades in a large t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ddd4f37533f21de10a6a5f9a8f417e1
https://doi.org/10.1007/s10875-023-01465-z
https://doi.org/10.1007/s10875-023-01465-z