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Pheno-seq - linking visual features and gene expression in 3D cell culture systems.

Autor: Tirier SM; Center for Quantitative Analysis of Molecular and Cellular Biosystems (BioQuant), University of Heidelberg, Heidelberg, Germany.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Chromatin Networks, German Cancer Research Center (DKFZ), Heidelberg, Germany., Park J; Digital Health Center, Berlin Institute of Health (BIH)/Charité-Universitätsmedizin Berlin, Berlin, Germany.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Preußer F; Center for Quantitative Analysis of Molecular and Cellular Biosystems (BioQuant), University of Heidelberg, Heidelberg, Germany.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Max Delbrück Center for Molecular Medicine, Berlin Institute for Medical Systems Biology, Berlin, Germany., Amrhein L; Helmholtz Zentrum München - German Research Center for Environmental Health, Institute of Computational Biology, Munich, Neuherberg, Germany.; Department of Mathematics, Technische Universität München, Munich, Germany., Gu Z; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Heidelberg Center for Personalized Oncology, DKFZ-HIPO, DKFZ, Heidelberg, Germany., Steiger S; Center for Quantitative Analysis of Molecular and Cellular Biosystems (BioQuant), University of Heidelberg, Heidelberg, Germany.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Mallm JP; Center for Quantitative Analysis of Molecular and Cellular Biosystems (BioQuant), University of Heidelberg, Heidelberg, Germany.; Division of Chromatin Networks, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Heidelberg Center for Personalized Oncology, DKFZ-HIPO, DKFZ, Heidelberg, Germany., Krieger T; Digital Health Center, Berlin Institute of Health (BIH)/Charité-Universitätsmedizin Berlin, Berlin, Germany.; Center for Quantitative Analysis of Molecular and Cellular Biosystems (BioQuant), University of Heidelberg, Heidelberg, Germany.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Waschow M; Center for Quantitative Analysis of Molecular and Cellular Biosystems (BioQuant), University of Heidelberg, Heidelberg, Germany.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Eismann B; Center for Quantitative Analysis of Molecular and Cellular Biosystems (BioQuant), University of Heidelberg, Heidelberg, Germany.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Gut M; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain., Gut IG; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain., Rippe K; Center for Quantitative Analysis of Molecular and Cellular Biosystems (BioQuant), University of Heidelberg, Heidelberg, Germany.; Division of Chromatin Networks, German Cancer Research Center (DKFZ), Heidelberg, Germany., Schlesner M; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Bioinformatics and Omics Data Analytics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Theis F; Helmholtz Zentrum München - German Research Center for Environmental Health, Institute of Computational Biology, Munich, Neuherberg, Germany.; Department of Mathematics, Technische Universität München, Munich, Germany., Fuchs C; Helmholtz Zentrum München - German Research Center for Environmental Health, Institute of Computational Biology, Munich, Neuherberg, Germany.; Department of Mathematics, Technische Universität München, Munich, Germany.; Faculty of Business Administration and Economics, Bielefeld University, Bielefeld, Germany., Ball CR; Department of Translational Oncology, NCT Dresden, University Hospital, Carl Gustav Carus, Technische Universität Dresden, Dresden and DKFZ, Heidelberg, Germany., Glimm H; Department of Translational Oncology, NCT Dresden, University Hospital, Carl Gustav Carus, Technische Universität Dresden, Dresden and DKFZ, Heidelberg, Germany.; German Cancer Consortium, Heidelberg, Germany., Eils R; Digital Health Center, Berlin Institute of Health (BIH)/Charité-Universitätsmedizin Berlin, Berlin, Germany.; Center for Quantitative Analysis of Molecular and Cellular Biosystems (BioQuant), University of Heidelberg, Heidelberg, Germany.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Heidelberg Center for Personalized Oncology, DKFZ-HIPO, DKFZ, Heidelberg, Germany.; Health Data Science Unit, University Hospital Heidelberg, Heidelberg, Germany., Conrad C; Digital Health Center, Berlin Institute of Health (BIH)/Charité-Universitätsmedizin Berlin, Berlin, Germany. christian.conrad@bihealth.de.; Center for Quantitative Analysis of Molecular and Cellular Biosystems (BioQuant), University of Heidelberg, Heidelberg, Germany. christian.conrad@bihealth.de.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany. christian.conrad@bihealth.de.; Heidelberg Center for Personalized Oncology, DKFZ-HIPO, DKFZ, Heidelberg, Germany. christian.conrad@bihealth.de.

Publikováno v: Scientific reports [Sci Rep] 2019 Aug 26; Vol. 9 (1), pp. 12367. Date of Electronic Publication: 2019 Aug 26.