Non-muscle myosin IIB (Myh10) is required for epicardial function and coronary vessel formation during mammalian development.

Autor: Liam A Ridge, Karen Mitchell, Ali Al-Anbaki, Wasay Mohiuddin Shaikh Qureshi, Louise A Stephen, Gennadiy Tenin, Yinhui Lu, Irina-Elena Lupu, Christopher Clowes, Abigail Robertson, Emma Barnes, Jayne A Wright, Bernard Keavney, Elisabeth Ehler, Simon C Lovell, Karl E Kadler, Kathryn E Hentges

Publikováno v: PLoS Genetics, Vol 13, Iss 10, p e1007068 (2017)

The coronary vasculature is an essential vessel network providing the blood supply to the heart. Disruptions in coronary blood flow contribute to cardiac disease, a major cause of premature death worldwide. The generation of treatments for cardiovasc

Externí odkaz: https://doaj.org/article/4a841ebc5e44469a893feb2ef3277b47

Disease modeling of core pre-mRNA splicing factor haploinsufficiency

Autor: Kathryn E. Hentges, Huw B. Thomas, Weronika A. Buczek, Tracy A Briggs, Wasay Mohiuddin Shaikh Qureshi, Charlie Rowlands, Raymond T. O'Keefe, Katherine A. Wood, William G. Newman, Simon J. Hubbard

Publikováno v: Human Molecular Genetics
Wood, K, Rowland, C F, Shaikh Qureshi, W M, Thomas, H, Buczek, W, Briggs, T, Hubbard, S, Hentges, K, Newman, W & O'Keefe, R 2019, ' Disease modelling of core pre-mRNA splicing factor haploinsufficiency ', Hum Mol Genet, vol. 28, no. 22, pp. 3704-3723 . https://doi.org/10.1093/hmg/ddz169

The craniofacial disorder mandibulofacial dysostosis Guion-Almeida type is caused by haploinsufficiency of the U5 snRNP gene EFTUD2/SNU114. However, it is unclear how reduced expression of this core pre-mRNA splicing factor leads to craniofacial defe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26ada3ab6a68910034f47b973e67b596
https://pubmed.ncbi.nlm.nih.gov/31304552

Chick Embryonic Cardiomyocyte Micromass System for Assessing Developmental Cardiotoxicity of Drugs

Autor: Wasay Mohiuddin Shaikh, Qureshi, Margaret K, Pratten

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1797

Heart is the first mesodermal organ to develop and is sensitive to life-threatening toxic effects of drugs during development. A number of methods have been devised to study developmental cardiotoxic effects of drugs including micromass system. The m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::379c70f277a920553a3a06460d32c38e
https://pubmed.ncbi.nlm.nih.gov/29896690

Induced Pluripotent Stem Cells and Their Use in Cardiac and Neural Regenerative Medicine

Autor: Tereza Svadlakova, Stepanka Skalova, Wasay Mohiuddin Shaikh Qureshi, Kapil Dev, Jaroslav Mokry

Publikováno v: International Journal of Molecular Sciences, Vol 16, Iss 2, Pp 4043-4067 (2015)
International Journal of Molecular Sciences

Stem cells are unique pools of cells that are crucial for embryonic development and maintenance of adult tissue homeostasis. The landmark Nobel Prize winning research by Yamanaka and colleagues to induce pluripotency in somatic cells has reshaped the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f985bdb3a09e5da78faf818876e02dc
https://doi.org/10.3390/ijms16024043

Imaging Cleared Embryonic and Postnatal Hearts at Single-cell Resolution

Autor: Margarida Barroso, Yangyang Lu, Joseph E. Mazurkiewicz, David Shieh, Wasay Mohiuddin Shaikh Qureshi, Mingfu Wu, Lianjie Miao, Jingjing Li, Saiyang Hu

Publikováno v: Journal of Visualized Experiments.

Single clonal tracing and analysis at the whole-heart level can determine cardiac progenitor cell behavior and differentiation during cardiac development, and allow for the study of the cellular and molecular basis of normal and abnormal cardiac morp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5b11e9cc7dacd8211d836adf6d1607
https://doi.org/10.3791/54303