Výsledky vyhledávání - "Warwicker, James"

Web-based display of protein surface and pH-dependent properties for assessing the developability of biotherapeutics

Publikováno v: Hebditch, M & Warwicker, J 2019, ' Web-based display of protein surface and pH-dependent properties for assessing the developability of biotherapeutics ', Nature Scientific Reports . https://doi.org/10.1038/s41598-018-36950-8

Protein instability leads to reversible self-association and irreversible aggregation which is a major concern for developing new biopharmaceutical leads. Protein solution behaviour is dictated by the physicochemical properties of the protein and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3818::62b00e1cb3e03d4ad92fed44a56611d3
https://doi.org/10.1038/s41598-018-36950-8

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Prediction of reduction potentials of copper proteins with continuum electrostatics and density functional theory

Autor: Fowler, Nicholas, Blanford, Christopher F., Warwicker, James, De Visser, Samuel

Publikováno v: Fowler, N, Blanford, C F, Warwicker, J & De Visser, S 2017, ' Prediction of reduction potentials of copper proteins with continuum electrostatics and density functional theory ', Chemistry: A European Journal . https://doi.org/10.1002/chem.201702901

Blue copper proteins, such as azurin, show dramatic changes in Cu2+/Cu+ reduction potential upon mutation over the full physiological range. Hence they have important functions in electron transfer and oxidation chemistry and may have potential in bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3818::591a15c1b931a9df4f5c5a5a0c8189dd
https://doi.org/10.1002/chem.201702901

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Protein-Sol: A web tool for predicting protein solubility from sequence

Autor: Hebditch, Max, Carballo-Amador, M. Alejandro, Charonis, Spyros, Curtis, Robin, Warwicker, James

Publikováno v: Hebditch, M, Carballo-Amador, M A, Charonis, S, Curtis, R & Warwicker, J 2017, ' Protein-Sol: A web tool for predicting protein solubility from sequence ', Bioinformatics, vol. 33, no. 19, pp. 3098-3100 . https://doi.org/10.1093/bioinformatics/btx345

Motivation: Protein solubility is an important property in industrial and therapeutic applications. Prediction is a challenge, despite a growing understanding of the relevant physicochemical properties.Results: Protein-Sol is a web server for predict

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3818::7703cf2d9a1785073eb919577365216b
https://www.research.manchester.ac.uk/portal/en/publications/proteinsol-a-web-tool-for-predicting-protein-solubility-from-sequence(23d6a111-34a4-4f5b-9d25-1c39963928e2).html

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Features of reactive cysteines discovered through computation:from kinase inhibition to enrichment around protein degrons

Autor: Fowler, Nicholas, Blanford, Christopher F., De Visser, Samuel, Warwicker, James

Publikováno v: Fowler, N, Blanford, C F, De Visser, S & Warwicker, J 2017, ' Features of reactive cysteines discovered through computation : from kinase inhibition to enrichment around protein degrons. ', Scientific Reports, vol. 7, 16338 . https://doi.org/10.1038/s41598-017-15997-z

Large-scale characterisation of cysteine modification is enabling study of the physicochemical determinants of reactivity. We find that location of cysteine at the amino terminus of an α-helix, associated with activity in thioredoxins, is under-repr

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https://www.research.manchester.ac.uk/portal/en/publications/features-of-reactive-cysteines-discovered-through-computation(d6b6dffd-4ada-4ef7-94b7-d24098645870).html

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Protein-protein interactions in paralogues: Electrostatics modulates specificity on a conserved steric scaffold

Autor: Ivanov, Stefan, Cawley, Andrew, Huber, Roland G, Bond, Peter J., Warwicker, James

Publikováno v: PLoS ONE, Vol 12, Iss 10, p e0185928 (2017)
Ivanov, S, Cawley, A, Huber, R G, Bond, P J & Warwicker, J 2017, ' Protein-protein interactions in paralogues: electrostatics modulates specificity on a conserved steric scaffold ', PLoS ONE . https://doi.org/10.1371/journal.pone.0185928

An improved knowledge of protein-protein interactions is essential for better understanding of metabolic and signaling networks, and cellular function. Progress tends to be based on structure determination and predictions using known structures, alon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::eb5c3404d2ddbe11c5db5d475ccf70b5
http://europepmc.org/articles/PMC5634604?pdf=render