What is the Origin of the Regioselective C 3 -Hydroxylation of L-Arg by the Nonheme Iron Enzyme Capreomycin C?

Autor: Cao Y; Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, United Kingdom.; Department of Chemistry, The University of Manchester, Oxford Road, Manchester, M13 9PL, United Kingdom., Wong HPH; Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, United Kingdom.; Department of Chemical Engineering, The University of Manchester, Oxford Road, Manchester, M13 9PL, United Kingdom., Warwicker J; Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, United Kingdom.; School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Oxford Road, Manchester, M13 9PL, United Kingdom., Hay S; Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, United Kingdom.; Department of Chemistry, The University of Manchester, Oxford Road, Manchester, M13 9PL, United Kingdom., de Visser SP; Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, United Kingdom.; Department of Chemical Engineering, The University of Manchester, Oxford Road, Manchester, M13 9PL, United Kingdom.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Nov 26; Vol. 30 (66), pp. e202402604. Date of Electronic Publication: 2024 Oct 16.

Freezing and folding behavior in simple off-lattice heteropolymers

Autor: Magee, J. E., Warwicker, J., Lue, L.

We have performed parallel tempering Monte Carlo simulations using a simple continuum heteropolymer model for proteins. All ten heteropolymer sequences which we have studied have shown first-order transitions at low temperature to ordered states domi

Externí odkaz: http://arxiv.org/abs/cond-mat/0401291

Evolution and divergence of teleost adrenergic receptors: why sometimes 'the drugs don't work' in fish.

Autor: Joyce W; Department of Biology - Zoophysiology, Aarhus University, 8000 Aarhus C, Denmark., Warwicker J; Division of Molecular and Cellular Function, Faculty of Biology, Medicine and Health, Manchester Institute of Biotechnology, The University of Manchester, Manchester, M1 7DN, UK., Shiels HA; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PL, UK., Perry SF; Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, ON, Canada, K1N 6N5.

Publikováno v: The Journal of experimental biology [J Exp Biol] 2023 Oct 01; Vol. 226 (19). Date of Electronic Publication: 2023 Oct 12.

Modelling of auxin-binding protein 1 suggests that its C-terminus and auxin could compete for a binding site that incorporates a metal ion and tryptophan residue 44

Autor: Warwicker, J.

Publikováno v: Planta, 2001 Feb 01. 212(3), 343-347.

Externí odkaz: https://www.jstor.org/stable/23386120

Chemometrics in Protein Formulation: Stability Governed by Repulsion and Protein Unfolding.

Autor: Kulakova A; Department of Chemistry, Technical University of Denmark, Kemitorvet 207, Kongens, Lyngby 2800, Denmark., Augustijn D; Department of Food Science, Faculty of Science, University of Copenhagen, Rolighedsvej 26, Frederiksberg 1958, Denmark., El Bialy I; Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universitaet Muenchen, Butenandtstrasse 5, Munich 81377, Germany., Gentiluomo L; Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universitaet Muenchen, Butenandtstrasse 5, Munich 81377, Germany.; Wyatt Technology Europe GmbH, Hochstrasse 18, Dernbach 56307, Germany., Greco ML; Dosage Form Design and Development, AstraZeneca, Sir Aaron Klug Building, Granta Park, Cambridge CB21 6GH, U.K., Hervø-Hansen S; Division of Theoretical Chemistry, Department of Chemistry, Lund University, P.O. Box 124, Lund 22100, Sweden., Indrakumar S; Department of Chemistry, Technical University of Denmark, Kemitorvet 207, Kongens, Lyngby 2800, Denmark., Mahapatra S; Novozymes A/S, Krogshoejvej 36, Bagsvaerd 2880, Denmark., Martinez Morales M; Dosage Form Design and Development, AstraZeneca, Sir Aaron Klug Building, Granta Park, Cambridge CB21 6GH, U.K., Pohl C; Novozymes A/S, Krogshoejvej 36, Bagsvaerd 2880, Denmark., Polimeni M; Division of Theoretical Chemistry, Department of Chemistry, Lund University, P.O. Box 124, Lund 22100, Sweden., Roche A; Department of Chemical Engineering, Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K., Svilenov HL; Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universitaet Muenchen, Butenandtstrasse 5, Munich 81377, Germany., Tosstorff A; Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universitaet Muenchen, Butenandtstrasse 5, Munich 81377, Germany., Zalar M; Department of Chemistry, School of Natural Sciences, Faculty of Science and Engineering, and Manchester Institute of Biotechnology, The University of Manchester, Oxford Road, Manchester M13 9PL, U.K., Curtis R; Department of Chemical Engineering, Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K., Derrick JP; School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Oxford Road, Manchester M13 9PT, U.K., Frieß W; Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universitaet Muenchen, Butenandtstrasse 5, Munich 81377, Germany., Golovanov AP; Department of Chemistry, School of Natural Sciences, Faculty of Science and Engineering, and Manchester Institute of Biotechnology, The University of Manchester, Oxford Road, Manchester M13 9PL, U.K., Lund M; Division of Theoretical Chemistry, Department of Chemistry, Lund University, P.O. Box 124, Lund 22100, Sweden., Nørgaard A; Novozymes A/S, Krogshoejvej 36, Bagsvaerd 2880, Denmark., Khan TA; Pharmaceutical Development & Supplies, Pharma Technical Development Biologics Europe, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, Basel 4070, Switzerland., Peters GHJ; Department of Chemistry, Technical University of Denmark, Kemitorvet 207, Kongens, Lyngby 2800, Denmark., Pluen A; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, U.K., Roessner D; Wyatt Technology Europe GmbH, Hochstrasse 18, Dernbach 56307, Germany., Streicher WW; Novozymes A/S, Krogshoejvej 36, Bagsvaerd 2880, Denmark., van der Walle CF; Dosage Form Design and Development, AstraZeneca, Sir Aaron Klug Building, Granta Park, Cambridge CB21 6GH, U.K., Warwicker J; School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Oxford Road, Manchester M13 9PT, U.K., Uddin S; Dosage Form Design and Development, AstraZeneca, Sir Aaron Klug Building, Granta Park, Cambridge CB21 6GH, U.K., Winter G; Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universitaet Muenchen, Butenandtstrasse 5, Munich 81377, Germany., Bukrinski JT; CMCAssist ApS, Ole Maaløes Vej 3, Copenhagen N 2200, Denmark., Rinnan Å; Department of Food Science, Faculty of Science, University of Copenhagen, Rolighedsvej 26, Frederiksberg 1958, Denmark., Harris P; Department of Chemistry, Technical University of Denmark, Kemitorvet 207, Kongens, Lyngby 2800, Denmark.

Publikováno v: Molecular pharmaceutics [Mol Pharm] 2023 Jun 05; Vol. 20 (6), pp. 2951-2965. Date of Electronic Publication: 2023 May 05.