Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Warriner SL"'
Publikováno v:
FEBS Journal, 289(17), 5341-5358. Wiley-Blackwell
p53 plays a critical role in regulating diverse biological processes: DNA repair, cell cycle arrest, apoptosis and senescence. The p53 pathway has therefore served as the focus of multiple drug-discovery efforts. p53 is negatively regulated by hDMX a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128a262f09dd5c771a00b3d05ccf3835
https://doi.org/10.1111/febs.16433
https://doi.org/10.1111/febs.16433
Using the hDMX/14-3-3 interaction, acylhydrazone-based ligand-directed fragment ligation was used to identify protein–protein interaction (PPI) inhibitory peptide-fragment hybrids. Separation of the peptide-fragment hybrids into the components yiel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::544c98fea97388296c193657df1d5f1c
https://eprints.whiterose.ac.uk/186341/1/d2cb00025c.pdf
https://eprints.whiterose.ac.uk/186341/1/d2cb00025c.pdf
Treatment of 2,4,6‐trifluoropyridine with sodium imidazolate, then 2 equiv. sodium pyrazolate, in two reaction steps yields the title ligand L in 40 % overall yield. Crystalline [FeL2][BF4]2 and [FeL2][ClO4]2 are isostructural high‐spin complexes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::9e7265b0da5dd522a64b2119406d5b65
Publikováno v:
Dalton Transactions. 47:5269-5278
Silver(I) complexes of 2,4,6-tri(pyrazol-1-yl)pyridine (tpp), 2,4,6-tri(pyrazol-1-yl)pyrimidine (tpym), 2,4,6-tri(pyrazol-1-yl)-1,3,5-triazine (tpt) and 2,4-di(pyrazol-1-yl)-1,3,5-triazine (bpt) are reported. Dinuclear [Ag₂(μ-tpp)₂(MeCN)₂][BF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f8b1dffe8aa067f6990f048d697310
https://doi.org/10.1039/c8dt00640g
https://doi.org/10.1039/c8dt00640g
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Nature Communications
Nature Communications
The development of ‘designer’ organelles could be a key strategy to enable foreign pathways to be efficiently controlled within eukaryotic biotechnology. A fundamental component of any such system will be the implementation of a bespoke protein i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::55eaa5f72bbb1b86dab793b6ae3d762b
http://link.springer.com/article/10.1038/s41467-017-00487-7
http://link.springer.com/article/10.1038/s41467-017-00487-7
Using the HIF-1α transcription factor as a model, this manuscript illustrates how an extended sequence of α-amino acids in a polypeptide can be replaced with a non-natural topographical mimic of an α-helix comprised from an aromatic oligoamide. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::6f7587bd789774833ca97666fff6b9a6
https://eprints.whiterose.ac.uk/96585/13/c6cc01812b.pdf
https://eprints.whiterose.ac.uk/96585/13/c6cc01812b.pdf
Autor:
Burslem, GM, Kyle, HF, Prabhakaran, P, Breeze, AL, Edwards, TA, Warriner, SL, Nelson, A, Wilson, AJ
α-Helix proteomimetics represent an emerging class of ligands that can be used to inhibit an array of helix mediated protein-protein interactions. Within this class of inhibitor, aromatic oligobenzamide foldamers have been widely and succssefuly use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::ede68abcf66ad2bab9812ae3333a9152
Autor:
Fisher, M, Williamson, DJ, Burslem, GM, Plante, JP, Manfield, IW, Tiede, C, Ault, JR, Stockley, PG, Plein, S, Maqbool, A, Tomlinson, DC, Foster, R, Warriner, SL, Bon, RS
The development of novel protein-targeted MRI contrast agents crucially depends on the ability to derivatise suitable targeting moieties with a high payload of relaxation enhancer (e.g., gadolinium(III) complexes such as Gd-DOTA), without losing affi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::12626bbbb39ad8a1c9754a0bf3c5ab40
https://eprints.whiterose.ac.uk/91538/10/c5ra20359g.pdf
https://eprints.whiterose.ac.uk/91538/10/c5ra20359g.pdf
Chemical formation of dehydroalanine has been widely used for the post-translational modification of protein and peptides, however methods to incorporate multiple dehydroalanine residues into a single peptide have not been defined. We report the use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::394bb186a8878f98c643484c3263a1bd
Autor:
Branson, TR, McAllister, TE, Garcia-Hartjes, J, Fascione, MA, Ross, JF, Warriner, SL, Wennekes, T, Zuilhof, H, Turnbull, WB
Protein toxins produced by bacteria are the cause of many life-threatening diarrheal diseases. Many of these toxins, including cholera toxin (CT), enter the cell by first binding to glycolipids in the cell membrane. Inhibiting these multivalent prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::87b761773297fb97e3ccd0a76cafe6cf