Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Warren Winick-Ng"'
Autor:
Warren Winick-Ng, R. Jane Rylett
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by synapse dysfunction and cognitive impairment. Understanding the development and progression of AD is challenging, as the disease is highly complex and multifactori
Externí odkaz:
https://doaj.org/article/cafec4763808485ea6165b971e6e0bb0
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Choline acetyltransferase (ChAT) synthesizes the neurotransmitter acetylcholine in cholinergic neurons, and mutations of this enzyme are linked to the neuromuscular disorder congenital myasthenic syndrome (CMS). One CMS-related mutation, V18M, reduce
Externí odkaz:
https://doaj.org/article/6f7e430a223a47008176558d502ad9dd
Autor:
Shawn Albers, Fatima Inthathirath, Sandeep K. Gill, Warren Winick-Ng, Ewa Jaworski, Daisy Y.L. Wong, Robert Gros, R. Jane Rylett
Publikováno v:
Neurobiology of Disease, Vol 69, Iss , Pp 32-42 (2014)
Alzheimer disease (AD) is associated with increased amyloidogenic processing of amyloid precursor protein (APP) to β-amyloid peptides (Aβ), cholinergic neuron loss with decreased choline acetyltransferase (ChAT) activity, and cognitive dysfunction.
Externí odkaz:
https://doaj.org/article/5dd48c5d7f914475a8a73e1fc3656dcd
Autor:
Connor Yanchus, Kristen L. Drucker, Thomas M. Kollmeyer, Ricky Tsai, Warren Winick-Ng, Minggao Liang, Ahmad Malik, Judy Pawling, Silvana B. De Lorenzo, Asma Ali, Paul A. Decker, Matt L. Kosel, Arijit Panda, Khalid N. Al-Zahrani, Lingyan Jiang, Jared W. L. Browning, Chris Lowden, Michael Geuenich, J. Javier Hernandez, Jessica T. Gosio, Musaddeque Ahmed, Sampath Kumar Loganathan, Jacob Berman, Daniel Trcka, Kulandaimanuvel Antony Michealraj, Jerome Fortin, Brittany Carson, Ethan W. Hollingsworth, Sandra Jacinto, Parisa Mazrooei, Lily Zhou, Andrew Elia, Mathieu Lupien, Housheng Hansen He, Daniel J. Murphy, Liguo Wang, Alexej Abyzov, James W. Dennis, Philipp G. Maass, Kieran Campbell, Michael D. Wilson, Daniel H. Lachance, Margaret Wrensch, John Wiencke, Tak Mak, Len A. Pennacchio, Diane E. Dickel, Axel Visel, Jeffrey Wrana, Michael D. Taylor, Gelareh Zadeh, Peter Dirks, Jeanette E. Eckel-Passow, Liliana Attisano, Ana Pombo, Cristiane M. Ida, Evgeny Z. Kvon, Robert B. Jenkins, Daniel Schramek
Publikováno v:
Science
Establishing causal links between inherited polymorphisms and cancer risk is challenging. Here, we focus on the single-nucleotide polymorphism rs55705857, which confers a sixfold greater risk of isocitrate dehydrogenase ( IDH) –mutant low-grade gli
Autor:
Mark A. Ungless, Izabela Harabula, Sarah A. Teichmann, Georg Dechant, Leonid Serebreni, Mandy Meijer, Vedran Franke, Luna Zea Redondo, Warren Winick-Ng, Andreas Abentung, Aleksandra A. Kolodziejczyk, Gonçalo Castelo-Branco, Rieke Kempfer, Christoph J. Thieme, Francesco Musella, Mario Nicodemi, Alexander Kukalev, Simona Bianco, Ana Pombo, Elena Torlai Triglia, Galina Apostolova, Luca Fiorillo, Eleanor J. Paul, Dominik Szabo, Ehsan Irani, Ibai Irastorza Azcarate, Andrea M. Chiariello, Altuna Akalin
Publikováno v:
BioRxiv
bioRxiv
bioRxiv
Neurons and oligodendrocytes are terminally differentiated cells that perform highly specialized functions, which depend on cascades of gene activation and repression to retain homeostatic control over a lifespan. Gene expression is regulated by thre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe90361604c71833d8063e04409eeb74
Autor:
Warren Winick-Ng, Bryan Heit, Trevor M. Morey, Jennifer Winick-Ng, R. Jane Rylett, Fabiana A. Caetano
Publikováno v:
Scientific Reports
The M-transcript of human choline acetyltransferase (ChAT) produces an 82-kDa protein (82-kDa ChAT) that concentrates in nuclei of cholinergic neurons. We assessed the effects of acute exposure to oligomeric amyloid-β1–42 (Aβ1–42) on 82-kDa ChA
Publikováno v:
Journal of neurochemistry. 128(5)
The sodium-coupled, hemicholinium-3-sensitive, high-affinity choline transporter (CHT) is responsible for transport of choline into cholinergic nerve terminals from the synaptic cleft following acetylcholine release and hydrolysis. In this study, we
Publikováno v:
BMC Pharmacology & Toxicology
Background Cocaine exposure has been reported to alter central μ-opioid receptor (MOR) expression in vivo. The present study employed an in vitro cellular model to explore possible mechanisms that may be involved in this action of cocaine. Methods T