Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Warren S.-L. Liao"'
Autor:
Zhen Lu, Warren S.-L. Liao, Hailing Yang, Margie N. Sutton, Robert C. Bast, Maojie Yang, Charlotte H. Clarke
Publikováno v:
Cell Death & Differentiation. 21:1275-1289
The process of autophagy has been described in detail at the molecular level in normal cells, but less is known of its regulation in cancer cells. Aplasia Ras homolog member I (ARHI; DIRAS3) is an imprinted tumor suppressor gene that is downregulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbb13082bc5d76e7c03b95f84f24b8ca
https://doi.org/10.1038/cdd.2014.48
https://doi.org/10.1038/cdd.2014.48
Autor:
Charlotte H. Clarke, Douglas A. Levine, Maojie Yang, Hailing Yang, Maria T. Baquero, Choel Kim, Albert S. Reger, Warren S.-L. Liao, Robert C. Bast, Zhen Lu
Publikováno v:
Autophagy. 10:1071-1092
DIRAS3 is an imprinted tumor suppressor gene that is downregulated in 60% of human ovarian cancers. Re-expression of DIRAS3 at physiological levels inhibits proliferation, decreases motility, induces autophagy, and regulates tumor dormancy. Functiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c13072ba9abd92f1ffb6a0106815c30
https://doi.org/10.4161/auto.28577
https://doi.org/10.4161/auto.28577
Autor:
Luisa Capalbo, Gabriel Lopez-Berestein, Robert C. Bast, David D.L. Bowtell, Warren S.-L. Liao, David M. Glover, Nuno L. Barbosa-Morais, Pablo E. Vivas-Mejia, Ahmed Ashour Ahmed, Geoffrey Bartholomeusz, Zhen Lu, Dariush Etemadmoghadam, Xiao Feng Le, Rodrigo Jacamo, Geoffrey Grandjean, Anil K. Sood, Michael Andreeff, Nicholas B. Jennings
SummaryRegulators of mitosis have been successfully targeted to enhance response to taxane chemotherapy. Here, we show that the salt inducible kinase 2 (SIK2) localizes at the centrosome, plays a key role in the initiation of mitosis, and regulates t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e336e470a9c5d6bc0c9fed5f13b9a8a2
https://ora.ox.ac.uk/objects/uuid:dc7cd1a4-f389-4870-b921-4c723d5915f5
https://ora.ox.ac.uk/objects/uuid:dc7cd1a4-f389-4870-b921-4c723d5915f5
Publikováno v:
JAK-STAT
Herein we review our progress on the development of phosphopeptide-based prodrugs targeting the SH2 domain of STAT3 to prevent recruitment to cytokine and growth factor receptors, activation, nuclear translocation and transcription of genes involved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f6c4bb727e30506c466166df080204
http://europepmc.org/articles/PMC3670284
http://europepmc.org/articles/PMC3670284
Autor:
Kumar Kaluarachchi, Warren S.-L. Liao, John S. McMurray, Xiaomin Chen, Zhiyong Ren, Pijus K. Mandal
Publikováno v:
International Journal of Peptide Research and Therapeutics. 19:3-12
Signal transducer and activator of transcription 3 (Stat3) transmits signals from growth factors and interleukin-6 family cytokines by binding to their receptors via its Src homology 2 (SH2) domain. This results in phosphorylation of Tyr705, dimeriza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6107be31f3e00c2b42d54b0f3834b4a
https://doi.org/10.1007/s10989-012-9313-0
https://doi.org/10.1007/s10989-012-9313-0
Autor:
Warren S.-L. Liao, Xiaomin Chen, J. Sanderson Birtwistle, Fengqin Gao, Pijus K. Mandal, John S. McMurray, Zhen Lu, Rajagopal Ramesh, Kumaralal Kaluarachchi, Robert C. Bast, Zhiyong Ren
Publikováno v:
Journal of Medicinal Chemistry. 54:3549-3563
Signal transducer and activator of transcription 3 (Stat3), a target for anticancer drug design, is activated by recruitment to phosphotyrosine residues on growth factor and cytokine receptors via its SH2 domain. We report here structure-activity rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c2fa6ec9adfb4f2114c2df06eef2d6
https://doi.org/10.1021/jm2000882
https://doi.org/10.1021/jm2000882
Autor:
Wen Huei Huang, Chii-Ming Lee, Warren S.-L. Liao, Yi Jie Chen, Shao-Chun Lu, Yuan-Teh Lee, Tracey A. Dugan, Po-Yuan Chang, Chu-Huang Chen, Shwu Fen Chang
Publikováno v:
Circulation Research. 102:933-941
Homocysteine (Hcy) contributes to atherogenesis and angiostasis by altering the phenotype of arterial endothelial cells (ECs). The present study was aimed at elucidating potential mechanisms by which Hcy can slow EC proliferation and induce EC apopto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b36cbd75b7109e2e78cc04928513922c
https://doi.org/10.1161/circresaha.108.171082
https://doi.org/10.1161/circresaha.108.171082
Autor:
Weiwei Feng, Robert Z. Luo, Warren S.-L. Liao, Zhen Lu, Yinhua Yu, Edward Seto, Xiaohong Zhang
Publikováno v:
International Journal of Cancer. 120:1664-1668
ARHI is a maternally imprinted tumor suppressor gene that is expressed in normal breast and ovarian epithelial cells but not in most breast and ovarian cancers. Our earlier studies showed that histone deacetylases (HDACs) in complexes with transcript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98b7dcbb1b317649f4708cc6fa6fb21
https://doi.org/10.1002/ijc.22474
https://doi.org/10.1002/ijc.22474
Autor:
Arata Nishmoto, Warren S.-L. Liao, Zhen Lu, E. Neely Atkinson, Carla L. Warneke, Maosheng Huang, Jinsong Liu, Yinhua Yu, Daniel G. Rosen, Hongqi Peng, Robert C. Bast, Robert Z. Luo
Publikováno v:
Clinical Cancer Research. 12:2404-2413
Purpose: ARHI expression is lost or markedly down-regulated in the majority of ovarian cancers. The mechanism by which ARHI is down-regulated in ovarian cancers is still not clear. Our previous reports indicated that ARHI promoter activity was reduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a205513e0bfe75e78022cf6bce8e9a63
https://doi.org/10.1158/1078-0432.ccr-05-1036
https://doi.org/10.1158/1078-0432.ccr-05-1036
Autor:
Yinhua Yu, Robert C. Bast, Xiang Mao, Zhiyong Ren, Zhen Lu, Stephanie S. Watowich, Arata Nishimoto, Robert Z. Luo, Warren S.-L. Liao, Xiaomin Chen, Gordon B. Mills
Publikováno v:
Cancer Research. 65:6701-6710
A Ras homologue member I (ARHI) is a novel imprinted tumor suppressor gene whose expression is frequently lost in breast and ovarian cancers. This small GTP-binding protein is a member of the Ras superfamily with significant homology to both Ras and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efdc0e442f0673dba9c173a8fb0b613f
https://doi.org/10.1158/0008-5472.can-05-0130
https://doi.org/10.1158/0008-5472.can-05-0130