Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Warren O, Haggard"'
Autor:
David J. Tennent, Stefanie M. Shiels, Jessica A. Jennings, Warren O. Haggard, Joseph C. Wenke
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 13, Iss 1, Pp 1-6 (2018)
Abstract Background Contaminated traumatic open orthopedic wounds are frequently complicated by polymicrobial contamination and infection. In high-risk wounds, the standard of care comprises debridement and irrigation combined with antibiotics which
Externí odkaz:
https://doaj.org/article/74ee4d7adcfd4c8abbcc88c8990d0c1b
Publikováno v:
Marine Drugs, Vol 17, Iss 9, p 517 (2019)
Mannitol, a polyalcohol bacterial metabolite, has been shown to activate dormant persister cells within bacterial biofilm. This study sought to evaluate an injectable blend of mannitol, chitosan, and polyethylene glycol for delivery of antibiotics an
Externí odkaz:
https://doaj.org/article/a6f838ada09242e999c23bf5460eb02b
Autor:
J. Amber Jennings, Karen E. Beenken, Joel D. Bumgardner, Mark S. Smeltzer, Zoe L. Harrison, Leslie Pace, Madison N. Brown, Warren O. Haggard
Publikováno v:
J Orthop Res
Antibiotic-loaded chitosan pastes have shown advantages in treatment and coverage of complex musculoskeletal defects. We added mannitol, previously shown to increase antibiotic susceptibility of biofilm, to an injectable chitosan/polyethylene glycol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbdd667ecb2f6b3e577bf4594e6119cc
https://doi.org/10.1002/jor.24986
https://doi.org/10.1002/jor.24986
Publikováno v:
Journal of Functional Biomaterials, Vol 3, Iss 1, Pp 114-130 (2012)
Composite chitosan-nano-hydroxyapatite microspheres and scaffolds prepared using a co-precipitation method have shown potential for use in bone regeneration. The goal of this research was to improve the functional properties of the composite scaffold
Externí odkaz:
https://doaj.org/article/61c42ffef2e84f92920b4cd50dc0c16a
Autor:
Joel D. Bumgardner, Fernanda D. Guerra, Jessica A. Jennings, Tomoko Fujiwara, Warren O. Haggard, Logan R. Boles
Publikováno v:
Int J Biol Macromol
Advanced local delivery systems are needed as adjunctive treatments for severe injuries with high infection rates, such as open fractures. Chitosan systems have been investigated as antimicrobial local delivery systems for orthopaedic infection but p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e85ea6ae83d699985f8b78bdb65dd33
https://doi.org/10.1016/j.ijbiomac.2019.04.075
https://doi.org/10.1016/j.ijbiomac.2019.04.075
Publikováno v:
Journal of Tissue Engineering, Vol 5 (2014)
The tendon/ligament-to-bone interface has a complex organization to enable transfer of forces through the tendon/ligament to the bone. The purpose of this study is to create a co-culture environment enabling a tissue-specific tendon region and tissue
Externí odkaz:
https://doaj.org/article/d3c18e04537142c2ba0f110dde5b2ba0
Autor:
Sanjay R. Mishra, Madhav Ghimire, A. Mohapatra, Michael A. Harris, Warren O. Haggard, Tomoko Fujiwara, Jessica A. Jennings, Bashir I. Morshed, Joel D. Bumgardner, David LeVine
Publikováno v:
EMBC
In this paper, we have presented a novel Drug Delivery Substrate (DDS) that that is responsive to external stimuli of high-frequency alternating magnetic fields. The DDS is constituted of chitosan crosslinked with PEGDMA (polyethylene glycol dimethac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97d4022ac5749231bf5b356c959c602
https://pubmed.ncbi.nlm.nih.gov/31946218
https://pubmed.ncbi.nlm.nih.gov/31946218
Autor:
Warren O. Haggard, Stefanie M. Shiels, Joseph C. Wenke, David J. Tennent, Jessica A. Jennings
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 13, Iss 1, Pp 1-6 (2018)
Journal of Orthopaedic Surgery and Research
Journal of Orthopaedic Surgery and Research
Background Contaminated traumatic open orthopedic wounds are frequently complicated by polymicrobial contamination and infection. In high-risk wounds, the standard of care comprises debridement and irrigation combined with antibiotics which can be ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623738bf62e65d38a0bac55d41703603
http://link.springer.com/article/10.1186/s13018-018-0760-y
http://link.springer.com/article/10.1186/s13018-018-0760-y
Autor:
David LeVine, Madhav Ghimire, Michael A. Harris, Jessica A. Jennings, Warren O. Haggard, Sanjay R. Mishra, Tomoko Fujiwara, Joel D. Bumgardner, Ankita Mohapatra, Bashir I. Morshed
Publikováno v:
Journal of Biomedical Materials Research Part B: Applied Biomaterials. 106:2169-2176
Local antibiotic delivery can overcome some of the shortcomings of systemic therapy, such as low local concentrations and delivery to avascular sites. A localized drug delivery system (DDS), ideally, could also use external stimuli to modulate the no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c2d206492d4e4d4c42a03e64b330dba
https://doi.org/10.1002/jbm.b.34015
https://doi.org/10.1002/jbm.b.34015