Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Warren N Schmidt"'
Autor:
Nirjal Bhattarai, James H McLinden, Jinhua Xiang, M Meleah Mathahs, Warren N Schmidt, Thomas M Kaufman, Jack T Stapleton
Publikováno v:
PLoS Pathogens, Vol 13, Iss 2, p e1006232 (2017)
Among human RNA viruses, hepatitis C virus (HCV) is unusual in that it causes persistent infection in the majority of infected people. To establish persistence, HCV evades host innate and adaptive immune responses by multiple mechanisms. Recent studi
Externí odkaz:
https://doaj.org/article/79fc8ec3de004f78ad5c3eef85bbee22
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0166853 (2017)
INTRODUCTION:Telomerase repairs the telomeric ends of chromosomes and is active in nearly all malignant cells. Hepatitis C virus (HCV) is known to be oncogenic and potential interactions with the telomerase system require further study. We determined
Externí odkaz:
https://doaj.org/article/71fc1fe9b9fd462599db190d2f6abc15
Publikováno v:
Frontiers in Pharmacology, Vol 3 (2012)
Hepatitis C virus, human immunodeficiency virus, and hepatitis B virus are chronic viral infections that cause considerable morbidity and mortality throughout the world. In the decades following the identification and sequencing of these viruses, in
Externí odkaz:
https://doaj.org/article/0b37cd98d33d40889472b912a80acb7e
Autor:
Zhaowen Zhu, Jerry C. Bommer, Warren N. Schmidt, M. Meleah Mathahs, Katherine Hu, Huy Tran, Charles A Testa
Publikováno v:
Drug Design, Development and Therapy. 14:757-771
Background Antiviral actions of tetrapyrroles have been described in a number of systems. Our goal was to evaluate antagonism of the HCV NS3-4A protease by a variety of common porphyrins and characterize structure-activity relationships that may be u
Autor:
Zhaowen Zhu, Jeffery L. Meier, Warren N. Schmidt, John A. Albert, Brian D. Fink, Huy Thien-Tuan Tran, Thomas O. Moninger, M. Meleah Mathahs, Ming Li
Publikováno v:
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives, Vol 9, Iss 6, Pp n/a-n/a (2021)
Pharmacology Research & Perspectives, Vol 9, Iss 6, Pp n/a-n/a (2021)
Zinc protoporphyrin (ZnPP), a naturally occurring metalloprotoporphyrin (MPP), is currently under development as a chemotherapeutic agent although its mechanism is unclear. When tested against other MPPs, ZnPP was the most effective DNA synthesis and
Autor:
Fernando Membreno, Giuseppe Morelli, Ray Thomason, Kalyan Ram Bhamidimarri, Dawn Torres, Andrew Scanga, Danielle Brandman, Guy W. Neff, Mark McKenzie, Stephen H. Caldwell, Kathleen E. Corey, Nadeem Anwar, Kimberly A. Brown, James Strobel, Sammy Saab, Thomas Amankonah, Bal R. Bhandari, Souvik Sarkar, Don C. Rockey, Miguel Á. Rodríguez, Mazen Noureddin, Edward Mena, Nikolaos Pyrsopoulos, Ayman Koteish, Gary A. Abrams, Andrew DeLemos, Richard Frederick, Bhaktasharan Patel, David T. Hagerty, Amy Stratton, Kathryn J. Lucas, Ethan M. Weinberg, Zeid Kayali, Anita Kohli, Marina Roytman, Kris V. Kowdley, Nicole Wedick, Brett E. Fortune, Michael P. Curry, Sofia Jakab, Kiran Bambha, Satinder Gill, Stevan A. Gonzalez, Nikunj Shah, Warren N. Schmidt, Jean L. Chan, Charles S. Landis, Bradley Freilich, Catherine Frenette, Hugo E. Vargas, Mary E. Rinella, Mohammad S. Siddiqui, Andrew P. Keaveny, George Therapondos, Elizabeth C. Verna, Ray Kim, James M. Robinson, David I. Bernstein, Marwan Ghabril, Reem Ghalib, John M. Vierling, Manal F. Abdelmalek, Paul J. Thuluvath, Jen-Jung Pan, Ravi Ravendhran, Amanda Wieland, Eric Lawitz, Justin Reynolds, Victor Ankoma-Sey, Mitchell L. Shiffman, Nyingi Kemmer, William M. Lee, Viviana Figueroa-Diaz, Douglas A. Simonetto, Jonathan Huang, Aasim Sheikh, Parvez S. Mantry, Harvey Tatum, Lance Stein
Publikováno v:
Journal of hepatology. 74(2)
Background & Aims Non-alcoholic steatohepatitis is a leading cause of end-stage liver disease. Hepatic steatosis and lipotoxicity cause chronic necroinflammation and direct hepatocellular injury resulting in cirrhosis, end-stage liver disease and hep
Autor:
Michael J. Kozal, Michael Fuchs, Yao Yu, Gretja Schnell, Warren N. Schmidt, Doris Toro, Daniel E. Cohen, Norbert Bräu, Susanna Naggie, Kristine Richards, Victoria M. Mullally, Mariem Charafeddine, Alexander Monto, Ramsey Cheung
Publikováno v:
Journal of Medical Virology
Hepatitis C virus (HCV) infections are more common among US veterans receiving care through Veterans Affairs (VA) Medical Centers than among the general population. Historically, HCV therapies had lower efficacy rates in VA patients, possibly due to
Autor:
Warren N. Schmidt, Zeid Kayali
Publikováno v:
Pharmacogenomics and Personalized Medicine
Chronic Hepatitis C virus (HCV) infection is the leading cause of advanced liver disease worldwide. The virus successfully evades host immune detection and for many years has hampered efforts to find a safe, uncomplicated, and reliable oral antiviral
Publikováno v:
Hepatology
Autor:
Ramsey Cheung, Ayse Aytaman, Hui Shen, Kyong-Mi Chang, Warren N. Schmidt, Marcos C. Pedrosa, Alexander Monto, Bhupinderjit S. Anand, David E. Kaplan, Timothy R. Morgan, James C. Ryan, Myrna L. Cozen, Christine Pocha, Norbert Bräu
Publikováno v:
Digestive diseases and sciences, vol 61, iss 6
BackgroundAs the era of interferon-alpha (IFN)-based therapy for hepatitis C ends, long-term treatment outcomes are now being evaluated.AimTo more fully understand the natural history of hepatitis C infection by following a multisite cohort of patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed71f8ef5637fcdb74451d683322420e
https://europepmc.org/articles/PMC5308124/
https://europepmc.org/articles/PMC5308124/