Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Warren M. Casey"'
Autor:
Kamel Mansouri, Neal F. Cariello, Alexandru Korotcov, Valery Tkachenko, Chris M. Grulke, Catherine S. Sprankle, David Allen, Warren M. Casey, Nicole C. Kleinstreuer, Antony J. Williams
Publikováno v:
Journal of Cheminformatics, Vol 11, Iss 1, Pp 1-20 (2019)
Abstract Background The logarithmic acid dissociation constant pKa reflects the ionization of a chemical, which affects lipophilicity, solubility, protein binding, and ability to pass through the plasma membrane. Thus, pKa affects chemical absorption
Externí odkaz:
https://doaj.org/article/4f55baf346f34fe88b0e95561bea6d46
Autor:
Alexander Sedykh, Neepa Y. Choksi, David G. Allen, Warren M. Casey, Ruchir Shah, Nicole C. Kleinstreuer
Publikováno v:
Chemical Research in Toxicology. 35:992-1000
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5d8c86a24deed1998300e46781192b3
https://doi.org/10.1021/acs.chemrestox.1c00443
https://doi.org/10.1021/acs.chemrestox.1c00443
Autor:
Warren M, Casey, Xiaoqing, Chang, David G, Allen, Patricia C, Ceger, Neepa Y, Choksi, Jui-Hua, Hsieh, Barbara A, Wetmore, Stephen S, Ferguson, Michael J, DeVito, Catherine S, Sprankle, Nicole C, Kleinstreuer
Publikováno v:
Environmental Health Perspectives
Background: To effectively incorporate in vitro data into regulatory use, confidence must be established in the quantitative extrapolation of in vitro activity to relevant end points in animals or humans. Objective: Our goal was to evaluate and optim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0addec334164cd75c0738a6a44225a7e
https://pubmed.ncbi.nlm.nih.gov/30192161
https://pubmed.ncbi.nlm.nih.gov/30192161
Publikováno v:
Biochemical and Biophysical Research Communications. 193:1297-1303
A fatty acid desaturase mutant was used to study the regulatory effects of unsaturated fatty acids on glycerolipid biosynthesis in yeast. Cells grown on palmitoleic acid (16:1) contain approximately twice the amount of phospholipids and triacylglycer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a58ba06b9af1647b7bb061b510cb5f
https://doi.org/10.1006/bbrc.1993.1766
https://doi.org/10.1006/bbrc.1993.1766
Publikováno v:
Archives of Biochemistry and Biophysics. 296:474-481
Saccharomyces cerevisiae sterol and heme auxotrophs were used to elucidate a role for hemes in sterol esterification. Steryl ester synthase (SES) activity was stimulated on average fourfold in cells supplemented with 50 micrograms/ml delta-aminolevul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62c650df49afd22012a97a9144c20d3
https://doi.org/10.1016/0003-9861(92)90600-2
https://doi.org/10.1016/0003-9861(92)90600-2
Autor:
C. Terrance Hawk, Stephen C. Lenhard, Carolyn Williams, Alan R. Olzinski, Warren M. Casey, Jeffrey J. Legos, Stephen J. Newsholme, Susanta K. Sarkar, Beat M. Jucker, Dewen Yang
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 293(5)
Peroxisome proliferator-activated receptor-δ (PPARδ) activation results in upregulation of genes associated with skeletal muscle fatty acid oxidation and mitochondrial uncoupling. However, direct, noninvasive assessment of lipid metabolism and mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c06ccf16d6dd31e3fd34b6122820b4
https://pubmed.ncbi.nlm.nih.gov/17726146
https://pubmed.ncbi.nlm.nih.gov/17726146
Autor:
Warren M. Casey, Leo W. Parks
Publikováno v:
Annual review of microbiology. 49
Fungi are among the most primitive organisms that synthesize sterols. The fungal sterol, ergosterol, is similar to animal sterol, cholesterol, but with significant structural differences. The genetics and biochemistry for most of the steps in sterol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::338f75a5333eb585ead12da2c0bf81c7
https://pubmed.ncbi.nlm.nih.gov/8561481
https://pubmed.ncbi.nlm.nih.gov/8561481
Using yeast strains with null mutations in structural genes which encode delta-aminolevulinic acid synthetase (HEM1), isozymes of 3-hydroxy-3-methylglutaryl coenzyme A (HMG1 and HMG2), squalene epoxidase (ERG1), and fatty acid delta 9-desaturase (OLE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df5b0379e9bc4100972db00150cdca77
https://europepmc.org/articles/PMC207422/
https://europepmc.org/articles/PMC207422/
Publikováno v:
Emerging Targets in Antibacterial and Antifungal Chemotherapy ISBN: 9781461364405
Most of the clinically useful antifungal agents either interact directly with the sterols in the fungal membrane or interfere with the synthesis of fungal sterols. The characteristics of these agents have been studied extensively in recent years, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cb3d5bd0deba648697508d63c134384
https://doi.org/10.1007/978-1-4615-3274-3_15
https://doi.org/10.1007/978-1-4615-3274-3_15
Publikováno v:
Biochimica et biophysica acta. 1081(3)
We measured the incorporation of radiolabeled methionine and acetate into the sterol component of G204, a Saccharomyces cerevisiae mutant strain which is partially heme competent. By comparing the amount of label incorporated into the sterol pool of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454c02031b4db61d4ed72c6d137e3505
https://pubmed.ncbi.nlm.nih.gov/1998746
https://pubmed.ncbi.nlm.nih.gov/1998746