Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Warren Ladiges"'
Autor:
Zhou Jiang, Juan Wang, Denise Imai, Tim Snider, Jenna Klug, Ruby Mangalindan, John Morton, Lida Zhu, Adam B. Salmon, Jackson Wezeman, Jiayi Hu, Vinal Menon, Nicholas Marka, Laura Neidernhofer, Warren Ladiges
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Pharmaceutical intervention of aging requires targeting multiple pathways, thus there is rationale to test combinations of drugs targeting different but overlapping processes. In order to determine if combining drugs shown to extend lifespan
Externí odkaz:
https://doaj.org/article/db55d8a2d1a2428eac1def333721ab8d
Autor:
Michael A. Davis, Kathleen Voss, J. Bryan Turnbull, Andrew T. Gustin, Megan Knoll, Antonio Muruato, Tien-Ying Hsiang, Kenneth H. Dinnon III, Sarah R. Leist, Katie Nickel, Ralph S. Baric, Warren Ladiges, Shreeram Akilesh, Kelly D. Smith, Michael Gale
Publikováno v:
Vaccines, Vol 11, Iss 1, p 47 (2022)
We present a comprehensive analysis of SARS-CoV-2 infection and recovery using wild type C57BL/6 mice and a mouse-adapted virus, and we demonstrate that this is an ideal model of infection and recovery that phenocopies acute human disease arising fro
Externí odkaz:
https://doaj.org/article/60f098023b5a49cb8e78a28adaf66d49
Autor:
Laura J. den Hartigh, Leela Goodspeed, Shari A. Wang, Heidi L. Kenerson, Mohamed Omer, Kevin D. O'Brien, Warren Ladiges, Raymond Yeung, Savitha Subramanian
Publikováno v:
Experimental Physiology, Vol 103, Iss 11, Pp 1469-1480 (2018)
New Findings What is the central question of this study? Whether chronic oral rapamycin promotes beneficial effects on glucose/lipid metabolism and energy balance when administered to mice with an obesogenic diet rich in saturated fat and sucrose has
Externí odkaz:
https://doaj.org/article/0d1ac30dac254f139ce9ae2ee60b9052
Autor:
Jessica M. Snyder, Kerriann M. Casey, Andrzej Galecki, David E. Harrison, Hashan Jayarathne, Navasuja Kumar, Francesca Macchiarini, Nadia Rosenthal, Marianna Sadagurski, Adam B. Salmon, Randy Strong, Richard A. Miller, Warren Ladiges
Publikováno v:
GeroScience. 45:385-397
Canagliflozin (Cana), a clinically important anti-diabetes drug, leads to a 14% increase in median lifespan and a 9% increase in the 90th percentile age when given to genetically heterogeneous male mice from 7 months of age, but does not increase lif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::815a84b77b6ad24dcfa81afeb6025f6c
https://doi.org/10.1007/s11357-022-00641-0
https://doi.org/10.1007/s11357-022-00641-0
Autor:
Gozde Yildirim, Edmara T. P. Bergamo, Sher Bahadur Poudel, Ryan R. Ruff, Manisha Dixit, Bin Hu, Dindo Q. Mijares, Lukasz Witek, Carolyn Chlebek, David E. Harrison, Randy Strong, Richard A. Miller, Warren Ladiges, Timothy G. Bromage, Clifford J. Rosen, Shoshana Yakar
Publikováno v:
GeroScience.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4408faf88b9d7fa36c8318227aba7aa0
https://doi.org/10.1007/s11357-023-00803-8
https://doi.org/10.1007/s11357-023-00803-8
Autor:
Chathurika Henpita, Rajesh Vyas, Chastity L. Healy, Tra L. Kieu, Aditi U. Gurkar, Matthew J. Yousefzadeh, Yuxiang Cui, Aiping Lu, Luise A. Angelini, Ryan D. O'Kelly, Sara J. McGowan, Sanjay Chandrasekhar, Rebecca R. Vanderpool, Danielle Hennessy‐Wack, Mark A. Ross, Timothy N. Bachman, Charles McTiernan, Smitha P. S. Pillai, Warren Ladiges, Mitra Lavasani, Johnny Huard, Donna Beer‐Stolz, Claudette M. St. Croix, Simon C. Watkins, Paul D. Robbins, Ana L. Mora, Eric E. Kelley, Yinsheng Wang, Timothy D. O'Connell, Laura J. Niedernhofer
Publikováno v:
Aging Cell. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a641669c22314fa0c7556a01110d0728
https://doi.org/10.1111/acel.13782
https://doi.org/10.1111/acel.13782
Autor:
Warren Ladiges
Publikováno v:
Aging Pathobiology and Therapeutics. 3:79-83
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88bdc7890b746c4239e00124ce23f6e3
https://doi.org/10.31491/apt.2021.12.070
https://doi.org/10.31491/apt.2021.12.070
Autor:
Jesse C Wiley, Jessica E. Young, Suman Jayadev, Martin Darvas, Russell H Swerdlow, Michael S. Wolfe, Laura M Heath, Jake Gockley, Gregory A. Cary, William L. Poehlman, Warren Ladiges, Gregory W Carter, Mark A Bothwell, Anna K Greenwood, Lara M Mangravite
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6f33ebaf49b0b1426618217870c72ad
https://doi.org/10.1002/alz.068190
https://doi.org/10.1002/alz.068190
Autor:
Manuela, Rosenfeld, Warren, Ladiges
Publikováno v:
Aging Pathobiol Ther
Slowing human aging with pharmaceuticals is now recognized as a feasible strategy. However, the design of clinical trials is still focused on single drug approaches. The process of aging has multiple pathways, which no current drug has been shown to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::64629143096766b66269291258763be4
https://pubmed.ncbi.nlm.nih.gov/36082207
https://pubmed.ncbi.nlm.nih.gov/36082207
Aging is a primary risk factor for cognitive dysfunction and exacerbates multiple biological processes in the brain, including but not limited to nutrient sensing dysregulation, insulin sensing dysfunction and histone deacetylation. Therefore, pharma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1fa9054e0c2646cbba56f67c08673f5
https://doi.org/10.1101/2022.09.07.506968
https://doi.org/10.1101/2022.09.07.506968
