Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Warren L. Simmons"'
Publikováno v:
Microbiology. 158:1867-1873
Although they lack a cell wall, mycoplasmas do possess a glycocalyx. The interactions between the glycocalyx, mycoplasmal surface proteins and host complement were explored using the murine pathogen Mycoplasma pulmonis as a model. It was previously s
Publikováno v:
FEMS Microbiology Letters. 311:51-55
Here, we describe mutants of Mycoplasma pulmonis that were obtained using a minitransposon, Tn4001TF1, which actively transposes but is then unable to undergo subsequent excision events. Using Tn4001TF1, we disrupted 39 genes previously thought to be
Publikováno v:
Molecular Microbiology. 72:1235-1245
Summary The presence of capsular exopolysaccharide (EPS) in Mollicutes has been inferred from electron micrographs for over 50 years without conclusive data to support the production of complex carbohydrates by the organism. Mycoplasma pulmonis binds
Autor:
Kevin Dybvig, Warren L. Simmons
Publikováno v:
FEMS Microbiology Letters. 295:77-81
Biofilms are communities of microorganisms that are encased in polymeric matrixes and grow attached to biotic or abiotic surfaces. Despite their enhanced ability to resist antimicrobials and components of the immune system in vitro, few studies have
Autor:
Warren L. Simmons, Kevin Dybvig
Publikováno v:
Microbe Magazine. 2:537-543
Even though free-living, mycoplasmas depend on their hosts for key nutrients, including purines, pyrimidines, several amino acids, and sterols, which are incorporated into the membranes of these wall-less bacteria. These requirements reflect their re
Autor:
Kevin Dybvig, Warren L. Simmons
Publikováno v:
Infection and Immunity. 75:3696-3699
The length of the tandem repeat region of the Vsa protein of Mycoplasma pulmonis has previously been shown to modulate the susceptibility of mycoplasmas to killing by complement: cells that produce a short form of the Vsa protein are highly sensitive
Publikováno v:
Journal of Bacteriology. 189:1905-1913
Bacterial biofilms are communities of bacteria that are enclosed in an extracellular matrix. Within a biofilm the bacteria are protected from antimicrobials, environmental stresses, and immune responses from the host. Biofilms are often believed to h
Autor:
Kevin Dybvig, T. Prescott Atkinson, Li Xiao, Elliot J. Lefkowitz, Travis Ptacek, Ken B. Waites, Warren L. Simmons, Donna M. Crabb, John D. Osborne
Publikováno v:
BMC Genomics
Background Mycoplasma pneumoniae is a common pathogen that causes upper and lower respiratory tract infections in people of all ages, responsible for up to 40 % of community-acquired pneumonias. It also causes a wide array of extrapulmonary infection
Autor:
Warren L. Simmons, Kevin Dybvig
Publikováno v:
Current microbiology. 71(2)
Mycoplasma pneumoniae causes chronic respiratory disease in humans. Factors thought to be important for colonization include the ability of the mycoplasma to form a biofilm on epithelial surfaces and the production of hydrogen peroxide to damage host
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143362 (2015)
PLoS ONE
PLoS ONE
The lack of a cell wall, flagella, fimbria, and other extracellular appendages and the possession of only a single membrane render the mycoplasmas structurally simplistic and ideal model organisms for the study of glycoconjugates. Most species have g