Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Warren K. Hoeffler"'
Publikováno v:
Experimental Cell Research. 258:270-278
The lifespan of human fibroblasts and other primary cell strains can be extended by expression of the telomerase catalytic subunit (hTERT). Since replicative senescence is accompanied by substantial alterations in gene expression, we evaluated charac
Autor:
Caroline Lanigan, Warren K. Hoeffler, David T. Woodley, C. Kathy Wang, Charlotte F. Nelson, Phyllis Pereira, Timothy Kutzkey, Elizabeth A. Welsh, Masaaki Morohashi, Chihiro Matsui
Publikováno v:
The Journal of Experimental Medicine
Junctional epidermolysis bullosa (JEB) is an autosomal recessive skin blistering disease with both lethal and nonlethal forms, with most patients shown to have defects in laminin-5. We analyzed the location of mutations, gene expression levels, and p
Publikováno v:
Experimental Cell Research. 233:330-339
Laminin-5 (previously known as kalinin, epiligrin, and nicein) is an adhesive protein localized to the anchoring filaments within the lamina lucida space of the basement membrane zone lying between the epidermis and dermis of human skin. Anchoring fi
Autor:
Steven G. Boxer, Warren K. Hoeffler, Dennis H. Oh, Michael W. Berns, Robert J. Stanley, Eugene A. Bauer, Michelle Lin
Publikováno v:
Photochemistry and Photobiology. 65:91-95
Psoralens are a class of pharmaceutical agents commonly used to treat several cutaneous disorders. When irradiated with a mode-locked titanium: sapphire (Ti:sapphire) laser tuned to 730 nm, an aqueous solution of 4'-hydroxymethyl-4,5',8-trimethylpsor
Publikováno v:
Nucleic Acids Research. 22:1305-1312
C-Jun is a cellular transcription factor that can control gene expression in response to treatment of cells with phorbol esters, growth factors, and expression of some oncogenes. The ability of c-Jun to catalyze the transcription of certain genes is
Autor:
Maria Barcova, Constance Mazurek, Paula M. Cannon, Warren K. Hoeffler, David T. Woodley, Douglas R. Keene, Mei Chen, Deborah Ruth Finlay, Lawrence S. Chan, Noriyuki Kasahara
Publikováno v:
Nature genetics. 32(4)
Dystrophic epidermolysis bullosa (DEB) is a family of inherited mechano-bullous disorders caused by mutations in the human type VII collagen gene (COL7A1). Individuals with DEB lack type VII collagen and anchoring fibrils, structures that attach epid
Autor:
Chihiro Matsui, G. Scott Herron, Eugene A. Bauer, Charlotte F. Nelson, German T. Hernandez, Warren K. Hoeffler
Publikováno v:
The Journal of investigative dermatology. 105(5)
Herlitz junctional epidermolysis bullosa is an autosomal recessive disorder characterized by generalized blistering at the lamina lucida of the cutaneous basement membrane. The monoclonal antibody GB3 has been used as a diagnostic probe because of it
Publikováno v:
The Journal of biological chemistry. 270(40)
Laminin-5 is a heterotrimer composed of alpha 3, beta 3, and gamma 2 chains, produced by keratinocytes and the human squamous cell carcinoma line (SCC-25), and is one of the candidate proteins for the genetic lesion in junctional epidermolysis bullos
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 9(13)
Type I collagenase plays an important role in both tumor metastasis and the remodeling of connective tissue in normal human skin, during wound healing, for example, and may participate in the pathophysiology of some dermatological diseases such as sk
Autor:
Youn H. Kim, Elaine N. Unemori, Cornelia Mauch, Warren K. Hoeffler, Eugene A. Bauer, Edward P. Amento
Publikováno v:
Experimental cell research. 211(2)
Recessive dystrophic epidermolysis bullosa (RDEB) is a mutilating disease of the skin characterized by recurrent blistering and erosions that result from compromised integrity of the basement membrane zone. In this study, fibroblasts derived from the