Perturbed Mitochondrial Dynamics Is a Novel Feature of Colitis That Can Be Targeted to Lessen DiseaseSummary

Autor: Rasha Sabouny, Nicolas Esquerre, Derek M. McKay, Nicole L. Mancini, Yasmin Nasser, Timothy E. Shutt, Jane Shearer, Sruthi Rajeev, Warren J. Xu, Erik van Tilburg Bernandes, Ala Al Rajabi, Jose G. Ferraz, Timothy S. Jayme, Arthur Wang, Luke J. L. Goudie

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 287-307 (2020)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Mitochondria exist in a constantly remodelling network, and excessive fragmentation can be pathophysiological. Mitochondrial dysfunction can accompany enteric inflammation, but any contribution of altered mitochondrial dynamics (ie,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fc08ce7c90989ef3a6199a0f6b24ffa
http://www.sciencedirect.com/science/article/pii/S2352345X20300485

Ketogenic diet leads to O-GlcNAc modification in the BTBR

Autor: Christopher, Newell, Virginia L, Johnsen, Nellie C, Yee, Warren J, Xu, Matthias S, Klein, Aneal, Khan, Jong M, Rho, Jane, Shearer

Publikováno v: Biochimica et biophysica acta. Molecular basis of disease. 1863(9)

Protein O-linked-β-N-acetyl glucosamine (O-GlcNAc) is a post-translational modification to Ser/Thr residues that integrates energy supply with demand. Abnormal O-GlcNAc patterning is evident in several neurological disease states including epilepsy,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7f28f65e0a3b0170afd6b796c05f0a1f
https://pubmed.ncbi.nlm.nih.gov/28502704