Synthesis of the non-peptidic snail toxin 6-bromo-2-mercaptotryptamine dimer (BrMT)2, its lower and higher thio homologs and their ability to modulate potassium ion channels

Autor: Hao Fu, Rheanna Sand, Warren J. Gallin, Detian Gao, Dennis G. Hall, Nazlee Sharmin

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 23:5503-5506

The first synthesis of the non-peptidic snail toxin 6-bromo-2-mercaptotryptamine dimer (BrMT)2 is described, along with the preparation of its lower and higher thio homologs. The synthetic (BrMT)2 and its derivatives reported herein are all capable o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956d0f6a7ccfde5b1434ad2702422825
https://doi.org/10.1016/j.bmcl.2013.08.070

jShaw1, a low-threshold, fast-activating Kv3 from the hydrozoan jellyfish Polyorchis penicillatus

Autor: Rheanna Sand, Warren J. Gallin, Donna M. Atherton, Andrew N. Spencer

Publikováno v: Journal of Experimental Biology. 214:3124-3137

SUMMARY Voltage-gated potassium (Kv) channels work in concert with other ion channels to determine the frequency and duration of action potentials in excitable cells. Little is known about Kv3 channels from invertebrates, but those that have been cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724a410c3408fe7b46f18cc01dc8af03
https://doi.org/10.1242/jeb.057000

Expression of a poriferan potassium channel: insights into the evolution of ion channels in metazoans

Autor: Bernard M. Degnan, Gabrielle J. Tompkins-MacDonald, Onur Sakarya, Sally P. Leys, Linda M. Boland, Warren J. Gallin

Publikováno v: Journal of Experimental Biology. 212:761-767

SUMMARY Ion channels establish and regulate membrane potentials in excitable and non-excitable cells. How functional diversification of ion channels contributed to the evolution of nervous systems may be understood by studying organisms at key positi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbd23c72579a6a5b653ce7a5c6a36bf
https://doi.org/10.1242/jeb.026971

A potassium channel (Kv4) cloned from the heart of the tunicateCiona intestinalisand its modulation by a KChIP subunit

Autor: Vicenta Salvador-Recatalà, Jennifer Abbruzzese, Warren J. Gallin, Andrew N. Spencer, Peter C. Ruben

Publikováno v: Journal of Experimental Biology. 209:731-747

SUMMARYVoltage-gated ion channels of the Kv4 subfamily produce A-type currents whose properties are tuned by accessory subunits termed KChIPs, which are a family of Ca2+ sensor proteins. By modifying expression levels and the intrinsic biophysical pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a802ecf73dabbdb14a7add3d910afd9b
https://doi.org/10.1242/jeb.02032

Calcium Channel Structural Determinants of Synaptic Transmission between Identified Invertebrate Neurons

Autor: J. David Spafford, Zhong-Ping Feng, David W. Munno, Gerald W. Zamponi, August B. Smit, Pim van Nierop, Naweed I. Syed, Warren J. Gallin, Scott E. Jarvis

Publikováno v: Spafford, J D, Munno, D W, van Nierop, P, Feng, Z P, Jarvis, S E, Gallin, W J, Smit, A B, Zamponi, G W & Syed, N I 2003, ' Calcium channel structural determinants of synaptic transmission between identified invertebrate neurons ', Journal of Biological Chemistry, vol. 278, no. 6, pp. 4258-4267 . https://doi.org/10.1074/jbc.M211076200
Journal of Biological Chemistry, 278(6), 4258-4267. American Society for Biochemistry and Molecular Biology Inc.

We report here that unlike what was suggested for many vertebrate neurons, synaptic transmission in Lymnaea stagnalis occurs independent of a physical interaction between presynaptic calcium channels and a functional complement of SNARE proteins. Ins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c7ad87a03121b8f32ab0abb7759a0d
https://doi.org/10.1074/jbc.m211076200