Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Warren H. Pettingell"'
Autor:
Dora M. Kovacs, Doo Yeon Kim, Bryce W. Carey, Warren H. Pettingell, Laura A. MacKenzie Ingano
Publikováno v:
Journal of Biological Chemistry. 280:23251-23261
The voltage-gated sodium channel beta2-subunit (beta2) is a member of the IgCAM superfamily and serves as both an adhesion molecule and an auxiliary subunit of the voltage-gated sodium channel. Here we found that beta2 undergoes ectodomain shedding f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c5cd55d7b94eb07e900dd0d917d203e
https://doi.org/10.1074/jbc.m412938200
https://doi.org/10.1074/jbc.m412938200
Publikováno v:
Archives of Biochemistry and Biophysics. 343:81-91
Ferritin mRNAs are translationally regulated by the binding of either of two cytosolic proteins, iron regulatory protein 1 (IRP1) or IRP2, to the iron responsive element (IRE) located in their 5' untranslated region (UTR). Rat liver IRP1 was purified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa959f23397d2d65485578368e5e538
https://doi.org/10.1006/abbi.1997.0144
https://doi.org/10.1006/abbi.1997.0144
Autor:
Rudolph E. Tanzi, Olivia G. Hallmark, Robert D. Moir, Warren H. Pettingell, Wilma Wasco, Tae-Wan Kim
Publikováno v:
Journal of Biological Chemistry. 272:11006-11010
Mutations in the presenilin genes, PS1 and PS2, cause a major portion of early onset familial Alzheimer's disease (FAD). The biological roles of the presenilins and how their pathological mutations confer FAD are unknown. In this study, we set out to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1702f486420e36ebf6764de75593629b
https://doi.org/10.1074/jbc.272.17.11006
https://doi.org/10.1074/jbc.272.17.11006
Publikováno v:
Journal of Biological Chemistry. 269:26618-26621
The Alzheimer beta-amyloid precursor protein (APP) contains an ectodomain zinc binding site that has been reported to modulate the heparin affinity and protease-inhibitory properties of the molecule. This motif, GVEFVCCP, is highly conserved in amylo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a384446c32e2a389e51598deeab4fa75
https://doi.org/10.1016/s0021-9258(18)47062-7
https://doi.org/10.1016/s0021-9258(18)47062-7
Publikováno v:
Journal of Biological Chemistry. 269:12152-12158
Abnormalities of zinc homeostasis occur in Alzheimer's disease (AD), a dementia characterized by the aggregation of A beta in the brain, and in Down syndrome, a condition characterized by premature AD. We studied the binding of Zn2+ to a synthetic pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ead00b6ea60c342f9d4150e37eb7ecfa
https://doi.org/10.1016/s0021-9258(17)32694-7
https://doi.org/10.1016/s0021-9258(17)32694-7
Autor:
Dora M. Kovacs, Birgit Hutter-Paier, Oksana Berezovska, Cory Barren, Camilla Peach, Warren H. Pettingell, Manfred Windisch, Henri J. Huttunen, Raja Bhattacharyya
Amyloid β-peptide (Aβ) has a central role in the pathogenesis of Alzheimer’s disease (AD). Cellular cholesterol homeostasis regulates endoproteolytic generation of Aβ from the amyloid precursor protein (APP). Previous studies have identified acy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e713aa09b8d32f1cc0f1af20896663
https://europepmc.org/articles/PMC2775008/
https://europepmc.org/articles/PMC2775008/
Publikováno v:
Proceedings of the National Academy of Sciences. 88:688-692
Synthesis of the iron-storage protein ferritin is thought to be regulated at the translational level by the cytosolic content of chelatable iron. This response to iron is regulated by the iron-modulated binding to ferritin mRNAs of a repressor protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2614bb884fc81d64cab6f05c141cb611
https://doi.org/10.1073/pnas.88.3.688
https://doi.org/10.1073/pnas.88.3.688
Autor:
Dora M. Kovacs, Clifford J. Woolf, Alexander M. Binshtok, Warren H. Pettingell, Laura A. MacKenzie Ingano, Doo Yeon Kim, Haibin Wang, Ping He, Bryce W. Carey, Virginia M.-Y. Lee, Mary H. Wertz
BACE1 activity is significantly increased in the brains of Alzheimer's disease patients, potentially contributing to neurodegeneration. The voltage-gated sodium channel (Na(v)1) beta2-subunit (beta2), a type I membrane protein that covalently binds t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96684612ec541db21752a37c469fb0b
https://europepmc.org/articles/PMC2747787/
https://europepmc.org/articles/PMC2747787/
Autor:
Doo Yeon Kim, Dora M. Kovacs, Mari K. Turunen, Bryce W. Carey, Warren H. Pettingell, Annakaisa Haapasalo
Publikováno v:
The Journal of biological chemistry. 282(12)
Leukocyte-common antigen-related (LAR) receptor tyrosine phosphatase regulates cell adhesion and formation of functional synapses and neuronal networks. Here we report that LAR is sequentially cleaved by alpha- and presenilin (PS)/gamma-secretases, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff040563d6b7e544ba1a3531a5ddee8
https://pubmed.ncbi.nlm.nih.gov/17259169
https://pubmed.ncbi.nlm.nih.gov/17259169
Publikováno v:
Alzheimer's & Dementia. 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a32b41002a5efb260319525b35537a57
https://doi.org/10.1016/j.jalz.2006.05.1664
https://doi.org/10.1016/j.jalz.2006.05.1664