Výsledky vyhledávání - "Warren Greth"

Population pharmacokinetic analysis of sifalimumab from a clinical phase IIb trial in systemic lupus erythematosus patients

Autor: Gabriel Robbie, Warren Greth, Bo Zheng, Xiang-Qing Yu

Publikováno v: British Journal of Clinical Pharmacology. 81:918-928

Aims Sifalimumab, a human immunoglobulin (Ig) G1 monoclonal antibody against INF-alpha, is being studied as a treatment for systemic lupus erythematosus (SLE). This analysis characterized population pharmacokinetics (PK) of sifalimumab following repe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18d1ba130af9621c821963eed52972e9
https://doi.org/10.1111/bcp.12864

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Targeting the interferon pathway with sifalimumab for the treatment of systemic lupus erythematosus

Autor: Philip Brohawn, Gabriel Robbie, Bing Yao, Micki Hultquist, Warren Greth

Publikováno v: Immunotherapy. 9(1)

Dysregulation of the type I interferon (IFN) system is associated with various immunologic diseases, such as systemic lupus erythematosus (SLE). Targeting this dysregulation presents an attractive approach for SLE therapy. Sifalimumab, a fully human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b2eb29385e3ccbc4eadf42d627eb6e5
https://pubmed.ncbi.nlm.nih.gov/28000522

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Suppression of soluble T cell-associated proteins by an anti-interferon- monoclonal antibody in adult patients with dermatomyositis or polymyositis

Autor: Brandon W. Higgs, Wei Zhu, Marlon Rebelatto, Wendy I. White, Xiang Guo, Warren Greth, Lorin Roskos, Yihong Yao

Publikováno v: Rheumatology (Oxford, England)

Objective. The aim of this study was to identify serum markers that are modulated by an investigational anti-IFN-α mAb, sifalimumab, in adult DM or PM patients. Methods. In a phase 1b clinical trial, sera were collected from a total of 48 DM or PM a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049f1b8051cc5658e59b2d22e42e22f2
https://doi.org/10.1093/rheumatology/ket413

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Impaired Health Status and the Effect of Pain and Fatigue on Functioning in Clinical Trial Patients with Systemic Lupus Erythematosus

Autor: Ariane K. Kawata, Kavita Gajria, Asha Hareendran, Warren Greth, Ancilla W. Fernandes, D Ethgen, Michelle Petri

Publikováno v: The Journal of Rheumatology. 40:1865-1874

Objective.Our study evaluated the impaired health status of clinical trial patients with systemic lupus erythematosus (SLE) and explored the relationship between changes in fatigue and pain and their effect on overall health status.Methods.Pooled tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00bf17bff757b4615c252cb2c4eee884
https://doi.org/10.3899/jrheum.130046

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Sifalimumab, a Human Anti–Interferon‐α Monoclonal Antibody, in Systemic Lupus Erythematosus: A Phase I Randomized, Controlled, Dose‐Escalation Study

Autor: Gabriel Robbie, Eduardo Mysler, L. Wang, Alberto Spindler, Michelle Petri, Daniel J. Wallace, Brandon W. Higgs, Kenneth C. Kalunian, C. Michael Neuwelt, Yihong Yao, D Ethgen, Wendy I. White, Warren Greth, Vishala Chindalore

Publikováno v: Arthritis & Rheumatism. 65:1011-1021

Objective To evaluate the safety and tolerability of multiple intravenous (IV) doses of sifalimumab in adults with moderate-to-severe systemic lupus erythematosus (SLE). Methods In this multicenter, double-blind, placebo-controlled, sequential dose-e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df4d124fbbe0108c1e64bc4a736e9cc
https://doi.org/10.1002/art.37824

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Medical costs and healthcare resource use in patients with lupus nephritis and neuropsychiatric lupus in an insured population

Autor: Daniel E. Furst, Kavita Gajria, Şerban R. Iorga, Ann E. Clarke, Ancilla W. Fernandes, Warren Greth, Tim Bancroft

Publikováno v: Journal of Medical Economics. 16:500-509

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect multiple organ systems, including the kidneys (lupus nephritis) and the central nervous system (neuropsychiatric lupus, or NPSLE). The healthcare costs and resource ut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45894e7b2696d98e7cb1ebfa96dd48df
https://doi.org/10.3111/13696998.2013.772058

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A phase 1b clinical trial evaluating sifalimumab, an anti-IFN-α monoclonal antibody, shows target neutralisation of a type I IFN signature in blood of dermatomyositis and polymyositis patients

Autor: Philip Brohawn, Chris Morehouse, Wei Zhu, Wendy I. White, Chenxiong Le, Steven A. Greenberg, Yihong Yao, Xiang Guo, Brandon W. Higgs, Bahija Jallal, Laura Richman, Marlon Rebelatto, David Fiorentino, Jorn Drappa, Warren Greth, Anthony A. Amato

Publikováno v: Annals of the Rheumatic Diseases

Objective To assess the pharmacodynamic effects of sifalimumab, an investigational anti-IFN-α monoclonal antibody, in the blood and muscle of adult dermatomyositis and polymyositis patients by measuring neutralisation of a type I IFN gene signature

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80deadba6819819b5ba2c39908f9d932
http://europepmc.org/articles/PMC3888620

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Sifalimumab, an anti-interferon-α monoclonal antibody, in moderate to severe systemic lupus erythematosus: a randomised, double-blind, placebo-controlled study

Autor: Warren Greth, Richard Furie, Joan T. Merrill, L. Wang, Kenneth C. Kalunian, Munther A. Khamashta, Jorn Drappa, G. Illei, Victoria P. Werth

Publikováno v: Annals of the rheumatic diseases, vol 75, iss 11
Khamashta, M, Merrill, J T, Werth, V P, Furie, R, Kalunian, K, Illei, G G, Drappa, J, Wang, L & Greth, W 2016, ' Sifalimumab, an anti-interferon-α monoclonal antibody, in moderate to severe systemic lupus erythematosus: a randomised, double-blind, placebo-controlled study ', Annals of the Rheumatic Diseases, vol. 75, no. 11, pp. 1909 . https://doi.org/10.1136/annrheumdis-2015-208562
Annals of the Rheumatic Diseases

ObjectivesThe efficacy and safety of sifalimumab were assessed in a phase IIb, randomised, double-blind, placebo-controlled study (NCT01283139) of adults with moderate to severe active systemic lupus erythematosus (SLE).Methods431 patients were rando

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::959afc7cbd93f227689c926a0911b7a3
https://escholarship.org/uc/item/8fw2369k

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Incidence and prevalence of adult systemic lupus erythematosus in a large US managed-care population

Autor: SR Iorga, Ancilla W. Fernandes, Ann E. Clarke, Warren Greth, T Bancroft, Daniel E. Furst

Publikováno v: Lupus. 22:99-105

Objective The objective of this paper is to determine the incidence and prevalence of adult systemic lupus erythematosus (SLE) in a large US managed-care population. Methods Subject inclusion in the incidence cohort required a medical claim with an S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49f2f071559fbc6e85d6c1c68e4ae1b
https://doi.org/10.1177/0961203312463110

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Epidemiology of Systemic Sclerosis in a Large US Managed Care Population

Autor: Daniel E. Furst, Ancilla W. Fernandes, Warren Greth, Tim Bancroft, Şerban R. Iorga

Publikováno v: The Journal of Rheumatology. 39:784-786

Objective.To estimate the incidence and prevalence of systemic sclerosis (SSc) in a large US managed care organization (MCO) database.Methods.Subjects with claims-based evidence of SSc (ICD-9-CM code 710.1x) were identified from a health plan databas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec4da7eedf8ae91547087a89eeb9bcf9
https://doi.org/10.3899/jrheum.111106

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