Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Warren G. Young"'
Publikováno v:
NeuroRX. 2:627-637
Summary: The future of neurodegenerative therapeutics development depends upon effective disease modification strategies centered on carefully investigated targets. Pharmaceutical research endeavors that probe for a much deeper understanding of disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc800e5911835e760fbaaff7cbb3148
https://doi.org/10.1602/neurorx.2.4.627
https://doi.org/10.1602/neurorx.2.4.627
Publikováno v:
Drug Discovery Today: BIOSILICO. 2:112-119
Central nervous system diseases constitute a major target for drug development. Genes expressed by the nervous system may represent half or more of the mammalian genome, with literally tens of thousands of gene products. Better methods are therefore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a20b91dfb82d605875f848abb67165a
https://doi.org/10.1016/s1741-8364(04)02400-x
https://doi.org/10.1016/s1741-8364(04)02400-x
Autor:
Chi-Cheng Wu, Russell E. Rydel, Stephen Freedman, John H. Morrison, Floyd E. Bloom, Dale Schenk, Warren G. Young, Faisal Chawla, Dora Games
Publikováno v:
Proceedings of the National Academy of Sciences. 101:7141-7146
Increasing evidence from mouse models of Alzheimer's disease shows that overexpression of a mutant form of the amyloid precursor protein (APP) and its product, β-amyloid peptide, initiate pathological changes before amyloid deposition. To evaluate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f897e42d7b1848613b788aa9fd9374fa
https://doi.org/10.1073/pnas.0402147101
https://doi.org/10.1073/pnas.0402147101
Autor:
Judith Cooper, John H. Morrison, David Lo, Warren G. Young, Floyd E. Bloom, Julie A. Ellison, Alain Trembleau, Ron S. Broide
Publikováno v:
Brain Research. 1000:211-222
In situ hybridization (ISH) is an essential technique for mapping gene expression in the brain. Although many ISH protocols provide for quantitative analysis of individual mRNAs in different brain regions or across experimental conditions, this techn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e656bea1cb4e99b5090a9a13c6b889
https://doi.org/10.1016/j.brainres.2003.11.069
https://doi.org/10.1016/j.brainres.2003.11.069
Autor:
Dale Schenk, John F. Reilly, John H. Morrison, Warren G. Young, Stephen Freedman, Russell E. Rydel, Dora Games, Floyd E. Bloom
Publikováno v:
Proceedings of the National Academy of Sciences. 100:4837-4842
Various transgenic mouse models of Alzheimer's disease (AD) have been developed that overexpress mutant forms of amyloid precursor protein in an effort to elucidate more fully the potential role of beta-amyloid (A beta) in the etiopathogenesis of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e323a87f20bea4dae5f4d06887f668b7
https://doi.org/10.1073/pnas.0330745100
https://doi.org/10.1073/pnas.0330745100
Publikováno v:
The Journal of Comparative Neurology. 420:113-126
Visual impairments that are not related to optical changes are not uncommon during aging, and a number of psychophysical investigations have documented deficits in motion detection as well as in spatiotemporal contrast sensitivity in elderly people.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d446efdf3cf3f5b5f0819acf4e8da9c
https://doi.org/10.1002/(sici)1096-9861(20000424)420:1<113::aid-cne8>3.0.co
https://doi.org/10.1002/(sici)1096-9861(20000424)420:1<113::aid-cne8>3.0.co
Autor:
Warren G. Young, John H. Morrison, Jon W. Gordon, Glendy Yeung, Esther A. Nimchinsky, Ravi A. Shah, Floyd E. Bloom, Patrick R. Hof
Publikováno v:
The Journal of Comparative Neurology. 416:112-125
In recent years, several mouse models of amyotrophic lateral sclerosis (ALS) have been developed. One, caused by a G86R mutation in the superoxide dismutase-1 (SOD-1) gene associated with familial ALS, has been subjected to extensive quantitative ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1538f86f00d1c464c062dc5a6aa6389a
https://doi.org/10.1002/(sici)1096-9861(20000103)416:1<112::aid-cne9>3.0.co
https://doi.org/10.1002/(sici)1096-9861(20000103)416:1<112::aid-cne9>3.0.co
Autor:
Oscar Prospéro-García, John H. Elder, Steven J. Henriksen, Howard S. Fox, Warren G. Young, Stanley Jacobson, Tom R. Phillips, Floyd E. Bloom
Publikováno v:
Journal of Neurovirology. 3:283-289
HIV-1 infection is often complicated by central nervous system (CNS) dysfunction. Degenerative neuronal changes as well as neuronal loss have been documented in individuals with AIDS. Feline immunodeficiency virus (FIV) infection of cats provides a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f8171c52eb7f0c084a8481de516125
https://doi.org/10.3109/13550289709029469
https://doi.org/10.3109/13550289709029469
Publikováno v:
The Journal of Comparative Neurology. 374:136-160
The primate cingulate gyrus contains multiple cortical areas that can be distinguished by several neurochemical features, including the distribution of neurofilament protein-enriched pyramidal neurons. In addition, connectivity and functional propert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75346eaf8208deeb0fe94337c3a4cd98
https://doi.org/10.1002/(sici)1096-9861(19961007)374:1<136::aid-cne10>3.0.co
https://doi.org/10.1002/(sici)1096-9861(19961007)374:1<136::aid-cne10>3.0.co
Publikováno v:
The Journal of Comparative Neurology. 341:476-491
Previous reports on the rat and monkey hypothalamus have revealed a dense noradrenergic innervation within the hypothalamic paraventricular nucleus as assessed by dopamine-beta-hydroxylase immunohistochemistry. These single-label analyses were unable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b165d60c6862a2ffc7ae8cfa023fa3
https://doi.org/10.1002/cne.903410405
https://doi.org/10.1002/cne.903410405