Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Warren Emmett"'
Autor:
Anne E Roehrig, Kristina Klupsch, Juan A Oses-Prieto, Selim Chaib, Stephen Henderson, Warren Emmett, Lucy C Young, Silvia Surinova, Andreas Blees, Anett Pfeiffer, Maha Tijani, Fabian Brunk, Nicole Hartig, Marta Muñoz-Alegre, Alexander Hergovich, Barbara H Jennings, Alma L Burlingame, Pablo Rodriguez-Viciana
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0254697 (2021)
The PAF complex (PAFC) coordinates transcription elongation and mRNA processing and its CDC73/parafibromin subunit functions as a tumour suppressor. The NF2/Merlin tumour suppressor functions both at the cell cortex and nucleus and is a key mediator
Externí odkaz:
https://doaj.org/article/060b7e02b03d49888281c2e401c2133d
Publikováno v:
BMC Medical Genomics, Vol 10, Iss 1, Pp 1-17 (2017)
Abstract Background Reliable exon recognition is key to the splicing of pre-mRNAs into mature mRNAs. TDP-43 is an RNA-binding protein whose nuclear loss and cytoplasmic aggregation are a hallmark pathology in amyotrophic lateral sclerosis and frontot
Externí odkaz:
https://doaj.org/article/ba8bd837cea54ca091c760638f3cc3b4
Autor:
Jan Attig, Igor Ruiz de los Mozos, Nejc Haberman, Zhen Wang, Warren Emmett, Kathi Zarnack, Julian König, Jernej Ule
Publikováno v:
eLife, Vol 5 (2016)
Alu elements are retrotransposons that frequently form new exons during primate evolution. Here, we assess the interplay of splicing repression by hnRNPC and nonsense-mediated mRNA decay (NMD) in the quality control and evolution of new Alu-exons. We
Externí odkaz:
https://doaj.org/article/2742a90fdd0c4b8cacf59ddf90269aa9
Publikováno v:
mBio, Vol 4, Iss 6 (2013)
ABSTRACT In this work, we show that Clostridium difficile phage ϕC2 transduces erm(B), which confers erythromycin resistance, from a donor to a recipient strain at a frequency of 10−6 per PFU. The transductants were lysogenic for ϕC2 and containe
Externí odkaz:
https://doaj.org/article/b70367b2f36a45f1a5af31a3cadcb6c9
Autor:
Daniah Trabzuni, Mina Ryten, Warren Emmett, Adaikalavan Ramasamy, Karl J Lackner, Tanja Zeller, Robert Walker, Colin Smith, Patrick A Lewis, Adamantios Mamais, Rohan de Silva, Jana Vandrovcova, International Parkinson Disease Genomics Consortium (IPDGC), Dena Hernandez, Michael A Nalls, Manu Sharma, Sophie Garnier, Suzanne Lesage, Javier Simon-Sanchez, Thomas Gasser, Peter Heutink, Alexis Brice, Andrew Singleton, Huaibin Cai, Eric Schadt, Nicholas W Wood, Rina Bandopadhyay, Michael E Weale, John Hardy, Vincent Plagnol
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70724 (2013)
Association studies have identified several signals at the LRRK2 locus for Parkinson's disease (PD), Crohn's disease (CD) and leprosy. However, little is known about the molecular mechanisms mediating these effects. To further characterize this locus
Externí odkaz:
https://doaj.org/article/aa919c6789b341e69f7b3a79a679c38a
Autor:
Maria Coakley, Prithika Sritharan, Guillermo Villacampa, Claire Swift, Kathryn Dunne, Lucy Kilburn, Katie Goddard, Patricia Rojas, Andy Joad, Warren Emmett, Charlene Knape, Karen Howarth, Peter S. Hall, Catherine Harper-Wynne, Tamas Hickish, Iain Macpherson, Alicia F. Okines, Andrew M. Wardley, Duncan Wheatley, Simon Waters, Rosalind Cutts, Isaac Garcia-Murillas, Judith Bliss, Nicholas Turner
Publikováno v:
Cancer Research. 83:PD5-03
Background: Detection of circulating tumour DNA (ctDNA) in patients (pts) who have completed treatment for early-stage breast cancer is associated with a high risk of future relapse. Identifying those at high risk of subsequent relapse may allow tail
Autor:
Filipa Almeida, Kavitha Siva, Oscar G. Wilkins, Gurvir S. Virdi, Warren Emmett, Elisavet Preza, Michela A. Denti, Jernej Ule, Claudia Manzoni, Alessandro Quattrone, Daniah Trabzuni, Victoria Kay, Mina Ryten, Thomas T. Warner, Roberto Simone, Jamie S. Mitchell, Natalia Barahona-Torres, Demis A. Kia, Per Svenningsson, Mazdak Ehteramyan, Andrew J. Lees, Raffaele Ferrari, Angelika Modelska, Geshanthi Hondhamuni, Jasmine Harley, Rohan de Silva, Vincent Plagnol, Rickie Patani, Alan Pittman, Justyna Zareba-Paslawska, John Hardy, Faiza Javad, Paola Zuccotti, Selina Wray
Publikováno v:
Nature
The human genome expresses thousands of natural antisense transcripts (NAT) that can regulate epigenetic state, transcription, RNA stability or translation of their overlapping genes1,2. Here we describe MAPT-AS1, a brain-enriched NAT that is conserv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d272b40dfe02a5f8381bb307045a35b
https://openaccess.sgul.ac.uk/id/eprint/113282/1/Simone2021_2016-04-05263D_text-Figures_final.pdf
https://openaccess.sgul.ac.uk/id/eprint/113282/1/Simone2021_2016-04-05263D_text-Figures_final.pdf
Autor:
Alma L. Burlingame, Warren Emmett, Andreas Blees, Fabian Brunk, Silvia Surinova, Anne E. Roehrig, Marta Munoz-Alegre, Alexander Hergovich, Kristina Klupsch, Maha Tijani, Anett Pfeiffer, Juan A. Oses-Prieto, Stephen Henderson, Pablo Rodriguez-Viciana, Nicole Hartig, Selim Chaib, Barbara H. Jennings, Lucy C. Young
Publikováno v:
PloS one, vol 16, iss 8
PLoS ONE
PLoS ONE, Vol 16, Iss 8, p e0254697 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 8, p e0254697 (2021)
The PAF complex (PAFC) coordinates transcription elongation and mRNA processing and its CDC73/parafibromin subunit functions as a tumour suppressor. The NF2/Merlin tumour suppressor functions both at the cell cortex and nucleus and is a key mediator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230e0538a32a3dbbdd2c44b48de833dd
https://escholarship.org/uc/item/57d9s6th
https://escholarship.org/uc/item/57d9s6th
Autor:
Jacqueline A Shaw, Justin Stebbing, Robert K. Hastings, Karen Howarth, David S. Guttery, Emma Green, Daniel Fernadez-Garcia, Kelly L. T. Gleason, Luke Martinson, Allison Hills, Nitzan Rosenfeld, Charlotte Ion, Laura M. Kenny, Farah Rehman, R. Charles Coombes, Amelia J Rushton, Karen Page, Andrijac Sanela, Susan Cleator, Georgios Nteliopoulos, Warren Emmett
Publikováno v:
Breast Cancer Research and Treatment
PurposeThere is growing interest in the application of circulating tumour DNA (ctDNA) as a sensitive tool for monitoring tumour evolution and guiding targeted therapy in patients with cancer. However, robust comparisons of different platform technolo
Autor:
Stephen R. D. Johnston, Ian E. Smith, Alistair Ring, Rosalind J. Cutts, Maria Coakley, Mitch Dowsett, Nicholas C. Turner, Malcolm Perry, Peter M. Ellis, Isaac Garcia-Murillas, Anthony Skene, Abigail Evans, Charlene Knape, Duncan Wheatley, Lara Ulrich, Karen Howarth, S. Russell, Warren Emmett
Publikováno v:
Cancer Research. 81:536-536
Introduction: Detection of circulating tumor DNA (ctDNA) presents a strategy to identify Molecular Residual Disease (MRD) in patients with breast cancer. Tools capable of detecting ctDNA at lower concentrations are needed to increase sensitivity and