Výsledky vyhledávání - "Warren E, Glaab"

Akademický článek

Performance of biomarkers NF-L, NSE, Tau and GFAP in blood and cerebrospinal fluid in rat for the detection of nervous system injury

Autor: Katerina Vlasakova, Takayuki Tsuchiya, Ivy N. Garfinkel, Michael P. Ruth, Cheryl Tyszkiewicz, Theodore J. Detwiler, Christopher J. Somps, Lorenzo Di Cesare Mannelli, Warren E. Glaab

Publikováno v: Frontiers in Neuroscience, Vol 17 (2024)

BackgroundTarget organ toxicity is often a reason for attritions in nonclinical and clinical drug development. Leveraging emerging safety biomarkers in nonclinical studies provides an opportunity to monitor such toxicities early and efficiently, pote

Externí odkaz: https://doaj.org/article/4d8d7f29be7c447e94c5af3685054aa9

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Akademický článek

Neurofilament light chain in plasma as a sensitive diagnostic biomarker of peripheral neurotoxicity: In Vivo mouse studies with oxaliplatin and paclitaxel - NeuroDeRisk project

Autor: David Balayssac, Jérôme Busserolles, Catherine Broto, Cristelle Dalbos, Laetitia Prival, Sylvain Lamoine, Damien Richard, Mercedes Quintana, Aurélia Herbet, Sandrine Hilairet, Yang Hu, Irena Loryan, Warren E. Glaab, Laura Micheli, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Olivier Perrault, Mohamed Slaoui

Publikováno v: Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115535- (2023)

Identifying compounds that are neurotoxic either toward the central or the peripheral nervous systems (CNS or PNS) would greatly benefit early stages of drug development by derisking liabilities and selecting safe compounds. Unfortunately, so far ass

Externí odkaz: https://doaj.org/article/efd0b2fddcb7403794d7295e4d4dd042

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Universal Accessible Biomarkers of Drug-Induced Tissue Injury and Systemic Inflammation in Rat: Performance Assessment of TIMP-1, A2M, AGP, NGAL, and Albumin

Autor: Katerina, Vlasakova, Jennifer, Bourque, Wendy J, Bailey, Shetal, Patel, Elizabeth G, Besteman, Raymond J, Gonzalez, Frank D, Sistare, Warren E, Glaab

Publikováno v: Toxicological Sciences. 187:219-233

The ability to monitor for general drug-induced tissue injury (DITI) or systemic inflammation in any tissue using blood-based accessible biomarkers would provide a valuable tool in early exploratory animal studies to understand potential drug liabili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b063b32a14b4046a9ff7c68d7d3fd6a5
https://doi.org/10.1093/toxsci/kfac030

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Kidney Injury Monitoring in Tobramycin-Treated Rhesus Monkeys: Supplementing Urinary Kidney Biomarkers With Kidney Biopsy Gene Expression Profiling

Autor: Stephanie Born, Yi-Zhong Gu, Larry Handt, Vasudevan Bakthavatchalu, Katerina Vlasakova, Frank D. Sistare, Guillermo Fernandez, Warren E. Glaab, Roger Smith

Publikováno v: Toxicologic Pathology. 50:35-46

Kidney biopsies are used sparingly to diagnose kidney injury in the clinic. Here we have conducted a small exploratory study to directly compare the low-grade kidney injury monitoring performance of serum safety biomarkers, novel urine safety biomark

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7000c83ea307a501b9d6a6443782431f
https://doi.org/10.1177/01926233211049171

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Early-Onset albuminuria and Associated Renal Pathology in Leucine-Rich Repeat Kinase 2 Knockout Rats

Autor: Yi-Zhong Gu, Katerina Vlasakova, Glen Miller, Nicholas T. Gatto, Paul J. Ciaccio, Sabu Kuruvilla, Elizabeth G. Besteman, Roger Smith, Spencer J. Reynolds, Rupesh P. Amin, Warren E. Glaab, Gordon Wollenberg, Jose Lebron, Frank D. Sistare

Publikováno v: Toxicologic Pathology. :019262332311628

Activating mutations of the leucine-rich repeat kinase 2 ( LRRK2) gene are associated with Parkinson disease (PD), prompting development of LRRK2 inhibitors as potential treatment for PD. However, kidney safety concerns have surfaced from LRRK2 knock

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca81b65118f034c663e621457909c3ff
https://doi.org/10.1177/01926233231162809

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A MicroRNA Next-Generation-Sequencing Discovery Assay (miND) for Genome-Scale Analysis and Absolute Quantitation of Circulating MicroRNA Biomarkers

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1226
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 23, Iss 1226, p 1226 (2022)

The plasma levels of tissue-specific microRNAs can be used as diagnostic, disease severity and prognostic biomarkers for chronic and acute diseases and drug-induced injury. Thereby, the combination of diverse microRNAs into biomarker signatures using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a23fdd332e91fec3548702c239d74d5

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Polyethlyene Glycol 200 Can Protect Rats Against Drug-Induced Kidney Toxicity Through Inhibition of the Renal Organic Anion Transporter 3

Autor: Bhavana Bhatt, Frank D. Sistare, Kiran Palyada, Feifei Chen, Isabelle Bourgeois, Christopher Brynczka, Rupesh P. Amin, Katerina Vlasakova, José A. Lebrón, Roger Smith, Kenneth A. Koeplinger, Kenneth D Anderson, Kathleen Cox, Robert Houle, Warren E. Glaab, Yi-Zhong Gu, Xiaoyan Chu

Publikováno v: Toxicological Sciences. 172:155-166

MK-7680, a cyclic nucleotide prodrug, caused significant kidney tubule injury in female rats when administered orally at 1000 mg/kg/day for 2 weeks using 10% Polysorbate 80 as vehicle. However, kidney injury was absent when MK-7680 was administered a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7c8a93f2d09b4d982560ba5c94462b
https://doi.org/10.1093/toxsci/kfz186

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AhR Activation in Pharmaceutical Development: Applying Liver Gene Expression Biomarker Thresholds to Identify Doses Associated With Tumorigenic Risks in Rats

Autor: Todd Pippert, Amy G Aslamkhan, Keith Q. Tanis, Stephen Pacchione, Chunhua Qin, Warren E. Glaab, Alexei A. Podtelezhnikov, Frank D. Sistare, Kara Pearson, Erika Frank

Publikováno v: Toxicological Sciences. 171:46-55

Aryl hydrocarbon receptor (AhR) activation is associated with carcinogenicity of non-genotoxic AhR-activating carcinogens such as 2,3,7,8-tetrachlorodibenzodioxin (TCDD), and is often observed with drug candidate molecules in development and raises s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09655b3ee0c00149bae8d17846d0bf5
https://doi.org/10.1093/toxsci/kfz125

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Translational Safety Biomarkers of Kidney Injury

Autor: Shashi Amur, Rupesh P. Amin, Katerina Vlasakova, Sean P. Troth, Warren E. Glaab

Publikováno v: Seminars in Nephrology. 39:202-214

Acute kidney injury continues to be a common problem and there continues to be a medical need for sensitive translational biomarkers for clinical monitoring. The past decade has yielded unprecedented progress in fundamental research into novel kidney

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963639c19be732c6ce807d060d2193e7
https://doi.org/10.1016/j.semnephrol.2018.12.008

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Universal Toxicity Gene Signatures for Early Identification of Drug-Induced Tissue Injuries in Rats

Autor: Thomas R. Skopek, Warren E. Glaab, Laura Michna, Carolann Beare, Wendy J. Bailey, Frank D. Sistare, Daniel J. Holder, Nagaraja Muniappa, David Gerhold, Joseph F. Sina, Yudong D He, Jeffrey W. Lawrence, Zoltan Erdos, Pamela Lane, Keith Q. Tanis

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 181(2)

A new safety testing paradigm that relies on gene expression biomarker panels was developed to easily and quickly identify drug-induced injuries across tissues in rats prior to drug candidate selection. Here, we describe the development, qualificatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d035f511764e56dbc4c0a33dd1ef1df
https://pubmed.ncbi.nlm.nih.gov/33837425

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