Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Warren D. Shlomchik"'
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
In hematopoietic stem cell transplants, T cells mediate graft-versus-leukemia (GVL), but GVL can fail leading to leukemia relapse. Here the authors use a mouse model in which T cells target the minor histocompatibility antigen H60 to show how this ca
Externí odkaz:
https://doaj.org/article/6c7bf027404348d5b25383a3383eaff2
Autor:
Sarah Morin-Zorman, Christian Wysocki, Jieqing Zhu, Hongmei Li, Sylvain Zorman, Catherine Matte-Martone, Edwina Kisanga, Jennifer McNiff, Dhanpat Jain, David Gonzalez, David M. Rothstein, Fadi G. Lakkis, Ann Haberman, Warren D. Shlomchik
Publikováno v:
Blood Advances, Vol 3, Iss 14, Pp 2082-2092 (2019)
Abstract: Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality in allogeneic hematopoietic stem cell transplantation (alloSCT). By static microscopy, cutaneous GVHD lesions contain a mix of T cells and myeloid cells. We used 2
Externí odkaz:
https://doaj.org/article/fd7cc965ad0547689fdd3e6ee81d0457
Autor:
Quan Zhuang, Quan Liu, Sherrie J. Divito, Qiang Zeng, Karim M. Yatim, Andrew D. Hughes, Darling M. Rojas-Canales, A. Nakao, William J. Shufesky, Amanda L. Williams, Rishab Humar, Rosemary A. Hoffman, Warren D. Shlomchik, Martin H. Oberbarnscheidt, Fadi G. Lakkis, Adrian E. Morelli
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Blocking T cell activation in organ transplantation is important to prevent rejection. Here the authors show that unconventional monocyte-derived host dendritic cells enter allogeneic grafts to amplify the T cell response outside lymph nodes.
Externí odkaz:
https://doaj.org/article/7df4dfdb27c84e1d8072441bd3894303
Autor:
Roger Tieu, Qiang Zeng, Daqiang Zhao, Gang Zhang, Neda Feizi, Priyanka Manandhar, Amanda L. Williams, Benjamin Popp, Michelle A. Wood-Trageser, Anthony J. Demetris, J. Yun Tso, Aaron J. Johnson, Lawrence P. Kane, Khodor I. Abou-Daya, Warren D. Shlomchik, Martin H. Oberbarnscheidt, Fadi G. Lakkis
Publikováno v:
Science Immunology. 8
Our understanding of tissue-resident memory T (T RM ) cell biology has been largely developed from acute infection models in which antigen is cleared and sterilizing immunity is achieved. Less is known about T RM cells in the context of chronic antig
Autor:
Emily Geramita, Kedwin Ventura, Shruti Bhise, Erika Moore, Elizabeth F. Krakow, Geoffrey R Hill, Scott N Furlan, Warren D Shlomchik, Sawa Ito
Publikováno v:
Transplantation and Cellular Therapy. 29:S45-S46
Autor:
Sawa Ito, Christine Voigt, Tim Mayall, Mark J Shlomchik, Jennifer D Roy, Egidio Brocca Cofano, Stephanie Stras, David Apelian, Robert Keefe, Warren D Shlomchik
Publikováno v:
Blood. 140:7482-7483
Autor:
Sawa Ito, Elizabeth F Krakow, Kedwin Ventura, Amy Rodger, Emily Geramita, Erika Moore, Geoffrey R Hill, Warren D Shlomchik
Publikováno v:
Blood. 140:7678-7679
Autor:
Faruk Sacirbegovic, Matthias Günther, Alessandro Greco, Daqiang Zhao, Xi Wang, Meng Zhou, Sarah Rosenberger, Martin H. Oberbarnscheidt, Werner Held, Jennifer McNiff, Dhanpat Jain, Thomas Höfer, Warren D. Shlomchik
Publikováno v:
Immunity. 56:369-385.e6
Autor:
Marie Bleakley, Alison Sehgal, Stuart Seropian, Melinda A. Biernacki, Elizabeth F. Krakow, Ann Dahlberg, Heather Persinger, Barbara Hilzinger, Paul J. Martin, Paul A. Carpenter, Mary E. Flowers, Jenna Voutsinas, Theodore A. Gooley, Keith Loeb, Brent L. Wood, Shelly Heimfeld, Stanley R. Riddell, Warren D. Shlomchik
Publikováno v:
J Clin Oncol
PURPOSE Graft-versus-host disease (GVHD) causes morbidity and mortality following allogeneic hematopoietic cell transplantation. Naive T cells (TN) cause severe GVHD in murine models. We evaluated chronic GVHD (cGVHD) and other outcomes in three phas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6817d1901eb3d9a3cfc38e9e7430844b
https://europepmc.org/articles/PMC8987226/
https://europepmc.org/articles/PMC8987226/
Autor:
Hehua Dai, Rayan Rammal, Douglas Landsittel, Daqiang Zhao, Martin H. Oberbarnscheidt, Fadi G. Lakkis, Warren D. Shlomchik, Amanda L. Williams, Roger Tieu, Khodor I. Abou-Daya, Adrian E. Morelli, Andrew D. Hughes
Publikováno v:
Journal of Clinical Investigation. 130:287-294
Activation of host T cells that mediate allograft rejection is a 2-step process. The first occurs in secondary lymphoid organs where T cells encounter alloantigens presented by host DCs and differentiate to effectors. Antigen presentation at these si