Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Warren C Ladiges"'
Autor:
Monique N O'Leary, Katherine H Schreiber, Yong Zhang, Anne-Cécile E Duc, Shuyun Rao, J Scott Hale, Emmeline C Academia, Shreya R Shah, John F Morton, Carly A Holstein, Dan B Martin, Matt Kaeberlein, Warren C Ladiges, Pamela J Fink, Vivian L Mackay, David L Wiest, Brian K Kennedy
Publikováno v:
PLoS Genetics, Vol 9, Iss 8, p e1003708 (2013)
Most yeast ribosomal protein genes are duplicated and their characterization has led to hypotheses regarding the existence of specialized ribosomes with different subunit composition or specifically-tailored functions. In yeast, ribosomal protein gen
Externí odkaz:
https://doaj.org/article/18c13070d632430da79e5d9b4c32c8dc
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80123 (2013)
Epidemiological research suggests that regular physical activity confers beneficial effects that mediate an anti-tumor response and may reduce cancer recurrence. It is unclear what amount of physical activity is necessary to exert such a protective e
Externí odkaz:
https://doaj.org/article/38ecf32a678b42be83ddad8d7d73bea1
Autor:
Richard L Frock, Steven C Chen, Dao-Fu Da, Ellie Frett, Carmen Lau, Christina Brown, Diana N Pak, Yuexia Wang, Antoine Muchir, Howard J Worman, Luis F Santana, Warren C Ladiges, Peter S Rabinovitch, Brian K Kennedy
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42918 (2012)
Lmna(-/-) mice display multiple tissue defects and die by 6-8 weeks of age reportedly from dilated cardiomyopathy with associated conduction defects. We sought to determine whether restoration of lamin A in cardiomyocytes improves cardiac function an
Externí odkaz:
https://doaj.org/article/474b2d0db8044ac2a121f210bd305299
Autor:
Jesse C Wiley, James S Meabon, Harald Frankowski, Elise A Smith, Leslayann C Schecterson, Mark Bothwell, Warren C Ladiges
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9135 (2010)
BACKGROUND: The familial and sporadic forms of Alzheimer's disease (AD) have an identical pathology with a severe disparity in the time of onset [1]. The pathological similarity suggests that epigenetic processes may phenocopy the Familial Alzheimer'
Externí odkaz:
https://doaj.org/article/93fef6035ed349bf90e598ff0b771e94
Autor:
Linda C Enns, John F Morton, Piper R Treuting, Mary J Emond, Norman S Wolf, Dao-Fu Dai, G S McKnight, Peter S Rabinovitch, Warren C Ladiges
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5963 (2009)
Mutations that cause a reduction in protein kinase A (PKA) activity have been shown to extend lifespan in yeast. Loss of function of mammalian RIIbeta, a regulatory subunit of PKA expressed in brain and adipose tissue, results in mice that are lean a
Externí odkaz:
https://doaj.org/article/f5f89b0c352a4d5982cb83d6dc30728e
Autor:
Gregory S. McElroy, Ram P. Chakrabarty, Karis B. D’Alessandro, Yuan-Shih Hu, Karthik Vasan, Jerica Tan, Joshua S. Stoolman, Samuel E. Weinberg, Elizabeth M. Steinert, Paul A. Reyfman, Benjamin D. Singer, Warren C. Ladiges, Lin Gao, José Lopéz‑Barneo, Karen Ridge, G. R. Scott Budinger, Navdeep S. Chandel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/bf88894a9fed4d829ae4270cde645adf
Autor:
Richard A. Miller, David E. Harrison, David B. Allison, Molly Bogue, Lucas Debarba, Vivian Diaz, Elizabeth Fernandez, Andrzej Galecki, W. Timothy Garvey, Hashan Jayarathne, Navasuja Kumar, Martin A. Javors, Warren C. Ladiges, Francesca Macchiarini, James Nelson, Peter Reifsnyder, Nadia A. Rosenthal, Marianna Sadagurski, Adam B. Salmon, Daniel L. Smith Jr., Jessica M. Snyder, David B. Lombard, Randy Strong
Publikováno v:
JCI Insight, Vol 5, Iss 21 (2020)
Canagliflozin (Cana) is an FDA-approved diabetes drug that protects against cardiovascular and kidney diseases. It also inhibits the sodium glucose transporter 2 by blocking renal reuptake and intestinal absorption of glucose. In the context of the m
Externí odkaz:
https://doaj.org/article/8346a43abd5742d2afbdcea95b0aa4d1
Autor:
Matthew D. Campbell, Ashton T. Samuelson, Ying Ann Chiao, Mariya T. Sweetwyne, Warren C. Ladiges, Peter S. Rabinovitch, David J. Marcinek
Publikováno v:
GeroScience.
The pathology of aging impacts multiple organ systems including the kidney, skeletal, and cardiac muscle. Long-term treatment with the mitochondrial targeted peptide elamipretide has previously been shown to improvein vivomitochondrial function in ag
Autor:
Philip R. McQuary, Chen-Yu Liao, Jessica T. Chang, Caroline Kumsta, Xingyu She, Andrew Davis, Chu-Chiao Chu, Sara Gelino, Rafael L. Gomez-Amaro, Michael Petrascheck, Laurence M. Brill, Warren C. Ladiges, Brian K. Kennedy, Malene Hansen
Publikováno v:
Cell Reports, Vol 14, Iss 9, Pp 2059-2067 (2016)
Deficiency of S6 kinase (S6K) extends the lifespan of multiple species, but the underlying mechanisms are unclear. To discover potential effectors of S6K-mediated longevity, we performed a proteomics analysis of long-lived rsks-1/S6K C. elegans mutan
Externí odkaz:
https://doaj.org/article/29b2484ea09e4ed5ac62471d7032b3bc
Autor:
Vera Gorbunova, Joydeep Mitra, Tina Gao, M. Reza Jabalameli, Almut Nebel, Matthias Laudes, Paul D. Robbins, Siegfried Görg, Quanwei Zhang, Alan R. Shuldiner, Valerio Napolioni, Kenny Ye, Nir Barzilai, Gil Atzmon, Warren C. Ladiges, Sofiya Milman, Yousin Suh, Guillermo G. Torres, Nha Nguyen, Zhengdong Zhang, Michael D. Greicius, Zhen Wang, Jhih Rong Lin, Jan Vijg, Patrick Sin-Chan, Andre Franke, Laura J. Niedernhofer
Publikováno v:
Nature Aging. 1:783-794
Extreme longevity in humans has a strong genetic component, but whether this involves genetic variation in the same longevity pathways as found in model organisms is unclear. Using whole-exome sequences of a large cohort of Ashkenazi Jewish centenari