Altered DNA methylation in leukocytes with trisomy 21.

Autor: Kristi Kerkel, Nicole Schupf, Kota Hatta, Deborah Pang, Martha Salas, Alexander Kratz, Mark Minden, Vundavalli Murty, Warren B Zigman, Richard P Mayeux, Edmund C Jenkins, Ali Torkamani, Nicholas J Schork, Wayne Silverman, B Anne Croy, Benjamin Tycko

Publikováno v: PLoS Genetics, Vol 6, Iss 11, p e1001212 (2010)

The primary abnormality in Down syndrome (DS), trisomy 21, is well known; but how this chromosomal gain produces the complex DS phenotype, including immune system defects, is not well understood. We profiled DNA methylation in total peripheral blood

Externí odkaz: https://doaj.org/article/4a35565dd02a46b89d706017f40d723e

Individualized estimated years from onset of Alzheimer's disease– related decline for adults with Down syndrome

Autor: Wayne Silverman, Sharon J. Krinsky‐McHale, Cynthia Kovacs, Joseph H. Lee, Tracy Listwan, Deborah I. Pang, Warren B. Zigman, Nicole Schupf

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 2, Pp n/a-n/a (2023)

Abstract Introduction Adults with Down syndrome (DS) are at increased risk for Alzheimer's disease (AD) and vary in their age of transition from AD preclinical to prodromal or more advanced clinical stages. An empirically based method is needed to de

Externí odkaz: https://doaj.org/article/b6af2015574f46abaf1715745275ea3c

Adults with Down syndrome in randomized clinical trials targeting prevention of Alzheimer's disease

Autor: Wayne, Silverman, Sharon J, Krinsky-McHale, Warren B, Zigman, Nicole, Schupf

Publikováno v: Alzheimers Dement

INTRODUCTION: Adults with Down syndrome, the largest population genetically predisposed to high risk for Alzheimer’s disease (AD), are ideally suited participants for clinical trials targeting prevention. Critically important considerations for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a86d4732cf40a89d07fa4b5186983150
https://pubmed.ncbi.nlm.nih.gov/34873819

Promising outcome measures of early Alzheimer's dementia in adults with Down syndrome

Autor: Nicole Schupf, Wayne Silverman, Joseph H. Lee, Cynthia Kovacs, Deborah Pang, Sharon J. Krinsky-McHale, Tracy Listwan, Warren B. Zigman

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring

Introduction Adults with Down syndrome (DS) are at high risk for developing Alzheimer's disease (AD) and its associated dementia, warranting the development of strategies to improve early detection when prevention is possible. Methods Using a broad b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce26b1d86d7f1af3f71387c6d92a6a33
https://doaj.org/article/ee807874e26d4e8d95b14100f009a813

Epidemiology of estrogen and dementia in women with Down syndrome

Autor: Warren B. Zigman, Deborah Pang, Benjamin Tycko, Nicole Schupf, Sharon J. Krinsky-McHale, Joseph H. Lee, Wayne Silverman

Publikováno v: Free Radical Biology and Medicine. 114:62-68

Several lines of investigation have shown a protective role for estrogen in Alzheimer’s disease through a number of biological actions. This review examines studies of the role of estrogen-related factors in age at onset and risk for Alzheimer’s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b358f4bc108feb616f4e81bb886da979
https://doi.org/10.1016/j.freeradbiomed.2017.08.019