Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Warren, Wakarchuk"'
Autor:
Christian Lizak, Liam J. Worrall, Lars Baumann, Moritz M. Pfleiderer, Gesa Volkers, Tianjun Sun, Lyann Sim, Warren Wakarchuk, Stephen G. Withers, Natalie C. J. Strynadka
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Polysialic acid (polySia) is a homopolymeric saccharide that is associated with some neuroinvasive pathogens and is found on selective cell types in their eukaryotic host. The presence of a polySia capsule on these bacterial pathogens helps
Externí odkaz:
https://doaj.org/article/fabd1f28b66b4a33a5fbc85e3dd477c6
Autor:
Hirak Saxena, Nakita Buenbrazo, Won-Yong Song, Connie Li, Denis Brochu, Anna Robotham, Wen Ding, Luc Tessier, Rui Chen, John Kelly, Warren Wakarchuk
Publikováno v:
Glycobiology.
The Actinobacterial species Cellulomonas fimi ATCC484 has long been known to secrete mannose-containing proteins, but a closer examination of glycoproteins associated with the cell has never been reported. Using ConA lectin chromatography and mass sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87ded9a8064ec8e59cd8c54e3a3c70f0
https://doi.org/10.1093/glycob/cwad023
https://doi.org/10.1093/glycob/cwad023
Autor:
Carmanah Hunter, Zhizeng Gao, Hong-Ming Chen, Nicole Thompson, Warren Wakarchuk, Mark Nitz, Stephen G. Withers, Lisa M. Willis
Publikováno v:
ACS chemical biology.
Sialic acids are key mediators of cell function, particularly with regards to cellular interactions with the surrounding environment. Reagents that modulate the display of specific sialyl glycoforms at the cell surface would be useful biochemical too
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fab363550b293c98614849dad5cf4ef
https://pubmed.ncbi.nlm.nih.gov/36577399
https://pubmed.ncbi.nlm.nih.gov/36577399
Autor:
Nicole Thompson, Warren Wakarchuk
Publikováno v:
Bioscience Reports. 42
Protein glycosylation is ubiquitous throughout biology. From bacteria to humans, this post translational modification with sophisticated carbohydrate structures plays a profound role in the interaction of proteins with cells and changes the physioche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd2146d663cb206e03b5627813f97de
https://doi.org/10.1042/bsr20220094
https://doi.org/10.1042/bsr20220094
Autor:
Michael B Tropak, Sayuri Yonekawa, Subha Karumuthil-Melethil, Patrick Thompson, Warren Wakarchuk, Steven J Gray, Jagdeep S Walia, Brian L Mark, Don Mahuran
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Tay-Sachs or Sandhoff disease result from mutations in either the evolutionarily related HEXA or HEXB genes encoding respectively, the α- or β-subunits of β-hexosaminidase A (HexA). Of the three Hex isozymes, only HexA can interact with its cofact
Externí odkaz:
https://doaj.org/article/6de70c93a5c54cd896357242c801a7ab
Autor:
Brendon J. Medley, Leif Leclaire, Nicole Thompson, Keira E. Mahoney, Benjamin Pluvinage, Matthew A.H. Parson, John E. Burke, Stacy Malaker, Warren Wakarchuk, Alisdair B. Boraston
Publikováno v:
Journal of Biological Chemistry. 298:102439
Akkermansia muciniphila is key member of the human gut microbiota that impacts many features of host health. A major characteristic of this bacterium is its interaction with host mucin, which is abundant in the gut environment, and its ability to met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20c90d8eb2f7f021b8e5368de5b2ea4
https://doi.org/10.1016/j.jbc.2022.102439
https://doi.org/10.1016/j.jbc.2022.102439
Autor:
Benjamin, Pluvinage, Elizabeth, Ficko-Blean, Ilit, Noach, Christopher, Stuart, Nicole, Thompson, Hayden, McClure, Nakita, Buenbrazo, Warren, Wakarchuk, Alisdair B, Boraston
Publikováno v:
Proc Natl Acad Sci U S A
A challenge faced by peptidases is the recognition of highly diverse substrates. A feature of some peptidase families is the capacity to specifically use post-translationally added glycans present on their protein substrates as a recognition determin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f8c5434418ad529375713554d931be63
https://pubmed.ncbi.nlm.nih.gov/33658366
https://pubmed.ncbi.nlm.nih.gov/33658366
Autor:
Incilay Sinici, Sayuri Yonekawa, Ilona Tkachyova, Steven J Gray, R Jude Samulski, Warren Wakarchuk, Brian L Mark, Don J Mahuran
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57908 (2013)
The hydrolysis in lysosomes of GM2 ganglioside to GM3 ganglioside requires the correct synthesis, intracellular assembly and transport of three separate gene products; i.e., the alpha and beta subunits of heterodimeric beta-hexosaminidase A, E.C. # 3
Externí odkaz:
https://doaj.org/article/4df25f80c5ab47469e0a8236857830c9
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1954
Glycans play many important roles in bacterial biology and the complexity of the glycan structures requires biochemical assays in place to help characterize the biosynthetic pathways. Our focus has been on the use of enzymes from pathogens which make
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::18b5f733873335bf97918e807f2cbd5e
https://pubmed.ncbi.nlm.nih.gov/30864135
https://pubmed.ncbi.nlm.nih.gov/30864135
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::577ec505e8d76066a44186edbbf877c4
https://doi.org/10.1096/fasebj.27.1_supplement.lb182
https://doi.org/10.1096/fasebj.27.1_supplement.lb182