Spirocyclic pyrrolidinyl nitroxides with exo-methylene substituents.

Autor: Sowiński MP; UiT The Arctic University of Norway, Department of Chemistry, Postboks 6050 Stakkevollan, 9037, Tromsø, NORWAY., Warnke AL; UiT The Arctic University of Norway, Department of Chemistry, Postboks 6050 Stakkevollan, 9037, Tromsø, NORWAY., Lund BA; UiT The Arctic University of Norway, Department of Chemistry, Postboks 6050 Stakkevollan, 9037, Tromsø, NORWAY., Skagseth S; UiT The Arctic University of Norway, Department of Chemistry, Postboks 6050 Stakkevollan, 9037, Tromsø, NORWAY., Cordes DB; University of St Andrews, EaStCHEM School of Chemistry, North Haugh, KY16 9ST, St Andrews, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND., Lovett JE; University of St Andrews, SUPA School of Physics and Astronomy and BSRC, North Haugh, KY16 9SS, St Andrews, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND., Haugland MM; UiT The Arctic University of Norway Faculty of Science and Technology: UiT Norges arktiske universitet Fakultet for naturvitenskap og teknologi, Chemistry, Postboks 6050 Langnes, 9037, Tromsø, NORWAY.

Publikováno v: ChemPlusChem [Chempluschem] 2024 Jul 29, pp. e202400387. Date of Electronic Publication: 2024 Jul 29.

The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition.

Autor: Koller TO; Institute for Biochemistry and Molecular Biology, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany., Scheid U; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarland University Campus, 66123 Saarbrücken, Germany., Kösel T; Leibniz Universität Hannover, Institute of Organic Chemistry and Center for Biomolecular Drug Research (BMWZ), Schneiderberg 1B, 30167 Hannover, Germany., Herrmann J; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarland University Campus, 66123 Saarbrücken, Germany.; German Center for Infection Research (DZIF), partner site Hannover-Braunschweig, 38124 Braunschweig, Germany., Krug D; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarland University Campus, 66123 Saarbrücken, Germany.; Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany.; German Center for Infection Research (DZIF), partner site Hannover-Braunschweig, 38124 Braunschweig, Germany., Boshoff HIM; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, United States., Beckert B; Institute for Biochemistry and Molecular Biology, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany., Evans JC; SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research, Institute of Infectious Disease and Molecular Medicine and Department of Pathology, University of Cape Town, Rondebosch 7700, South Africa., Schlemmer J; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarland University Campus, 66123 Saarbrücken, Germany.; German Center for Infection Research (DZIF), partner site Hannover-Braunschweig, 38124 Braunschweig, Germany., Sloan B; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, United States., Weiner DM; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, United States., Via LE; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, United States., Moosa A; SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research, Institute of Infectious Disease and Molecular Medicine and Department of Pathology, University of Cape Town, Rondebosch 7700, South Africa., Ioerger TR; Department of Computer Science and Engineering, Texas A&M University, College Station, Texas 77843, United States., Graf M; Institute for Biochemistry and Molecular Biology, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany., Zinshteyn B; Department of Molecular Biology and Genetics, Johns Hopkins University, Baltimore, Maryland 21205, United States; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States., Abdelshahid M; Institute for Biochemistry and Molecular Biology, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany., Nguyen F; Institute for Biochemistry and Molecular Biology, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany., Arenz S; Institute for Biochemistry and Molecular Biology, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany., Gille F; Leibniz Universität Hannover, Institute of Organic Chemistry and Center for Biomolecular Drug Research (BMWZ), Schneiderberg 1B, 30167 Hannover, Germany., Siebke M; Leibniz Universität Hannover, Institute of Organic Chemistry and Center for Biomolecular Drug Research (BMWZ), Schneiderberg 1B, 30167 Hannover, Germany.; Institute of Medicinal Chemistry, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany., Seedorf T; Leibniz Universität Hannover, Institute of Organic Chemistry and Center for Biomolecular Drug Research (BMWZ), Schneiderberg 1B, 30167 Hannover, Germany., Plettenburg O; Leibniz Universität Hannover, Institute of Organic Chemistry and Center for Biomolecular Drug Research (BMWZ), Schneiderberg 1B, 30167 Hannover, Germany.; Institute of Medicinal Chemistry, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany., Green R; Department of Molecular Biology and Genetics, Johns Hopkins University, Baltimore, Maryland 21205, United States; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States., Warnke AL; Leibniz Universität Hannover, Institute of Organic Chemistry and Center for Biomolecular Drug Research (BMWZ), Schneiderberg 1B, 30167 Hannover, Germany.; Institute of Medicinal Chemistry, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany., Ullrich J; MSD Animal Health Innovation GmbH, Zur Propstei, 55270 Schwabenheim, Germany., Warrass R; MSD Animal Health Innovation GmbH, Zur Propstei, 55270 Schwabenheim, Germany., Barry CE 3rd; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, United States., Warner DF; SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research, Institute of Infectious Disease and Molecular Medicine and Department of Pathology, University of Cape Town, Rondebosch 7700, South Africa., Mizrahi V; SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research, Institute of Infectious Disease and Molecular Medicine and Department of Pathology, University of Cape Town, Rondebosch 7700, South Africa., Kirschning A; Leibniz Universität Hannover, Institute of Organic Chemistry and Center for Biomolecular Drug Research (BMWZ), Schneiderberg 1B, 30167 Hannover, Germany., Wilson DN; Institute for Biochemistry and Molecular Biology, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany., Müller R; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarland University Campus, 66123 Saarbrücken, Germany.; Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany.; German Center for Infection Research (DZIF), partner site Hannover-Braunschweig, 38124 Braunschweig, Germany.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2023 Jan 18; Vol. 145 (2), pp. 851-863. Date of Electronic Publication: 2023 Jan 05.

Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes.

Autor: Sekar R; Institute for Diabetes and Cancer, Helmholtz Munich, Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany; German Center for Diabetes Research, Neuherberg, Germany., Motzler K; Institute for Diabetes and Cancer, Helmholtz Munich, Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany; German Center for Diabetes Research, Neuherberg, Germany., Kwon Y; Institute for Diabetes and Cancer, Helmholtz Munich, Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany; German Center for Diabetes Research, Neuherberg, Germany., Novikoff A; German Center for Diabetes Research, Neuherberg, Germany; Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany., Jülg J; Munich Cluster for Systems Neurology, Ludwig-Maximilians-University, Munich, Germany., Najafi B; Institute for Diabetes and Cancer, Helmholtz Munich, Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany; German Center for Diabetes Research, Neuherberg, Germany., Wang S; Institute for Diabetes and Cancer, Helmholtz Munich, Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany; German Center for Diabetes Research, Neuherberg, Germany., Warnke AL; German Center for Diabetes Research, Neuherberg, Germany; Institute of Medicinal Chemistry, Helmholtz Munich, Neuherberg, Germany; Institute of Organic Chemistry, Center of Biomolecular Research, Leibniz University, Hannover, Germany., Seitz S; Institute for Diabetes and Cancer, Helmholtz Munich, Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany; German Center for Diabetes Research, Neuherberg, Germany., Hass D; Institute for Diabetes and Cancer, Helmholtz Munich, Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany; German Center for Diabetes Research, Neuherberg, Germany., Gancheva S; German Center for Diabetes Research, Neuherberg, Germany; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; Institute for Clinical Diabetology, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany., Kahl S; German Center for Diabetes Research, Neuherberg, Germany; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; Institute for Clinical Diabetology, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany., Yang B; Novo Nordisk Research Center, Indianapolis, IN, USA., Finan B; Novo Nordisk Research Center, Indianapolis, IN, USA., Schwarz K; Department of General Paediatrics, Division of Neuropaediatrics and Metabolic Medicine, University Children's Hospital, Heidelberg University, Heidelberg, Germany., Okun JG; Department of General Paediatrics, Division of Neuropaediatrics and Metabolic Medicine, University Children's Hospital, Heidelberg University, Heidelberg, Germany., Roden M; German Center for Diabetes Research, Neuherberg, Germany; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; Institute for Clinical Diabetology, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany., Blüher M; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Munich at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany., Müller TD; German Center for Diabetes Research, Neuherberg, Germany; Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany., Krahmer N; German Center for Diabetes Research, Neuherberg, Germany; Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany., Behrends C; Munich Cluster for Systems Neurology, Ludwig-Maximilians-University, Munich, Germany., Plettenburg O; German Center for Diabetes Research, Neuherberg, Germany; Institute of Medicinal Chemistry, Helmholtz Munich, Neuherberg, Germany; Institute of Organic Chemistry, Center of Biomolecular Research, Leibniz University, Hannover, Germany., Miaczynska M; Laboratory of Cell Biology, International Institute of Molecular and Cell Biology, Warsaw, Poland., Herzig S; Institute for Diabetes and Cancer, Helmholtz Munich, Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany; German Center for Diabetes Research, Neuherberg, Germany; Chair Molecular Metabolic Control, Technical University Munich, Munich, Germany., Zeigerer A; Institute for Diabetes and Cancer, Helmholtz Munich, Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany; German Center for Diabetes Research, Neuherberg, Germany. Electronic address: anja.zeigerer@helmholtz-muenchen.de.

Publikováno v: Cell metabolism [Cell Metab] 2022 Nov 01; Vol. 34 (11), pp. 1824-1842.e9. Date of Electronic Publication: 2022 Oct 14.