Yellow fever disease severity and endothelial dysfunction are associated with elevated serum levels of viral NS1 protein and syndecan-1.

Autor: de Sousa FTG; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA; Departamento de Doenças Infecciosas e Parasitárias, Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP 05403000, Brazil; Laboratório de Investigação Médica, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP 05403000, Brazil. Electronic address: francielletg@gmail.com., Warnes CM; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA., Manuli ER; Departamento de Doenças Infecciosas e Parasitárias, Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP 05403000, Brazil; Laboratório de Investigação Médica, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP 05403000, Brazil., Tjang LV; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA., Carneiro PH; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA. Electronic address: pedrocarneiro@berkeley.edu., Maria de Oliveira Pinto L; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA; Laboratório das Interações Vírus-Hospedeiros (LIVH), Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (IOC/Fiocruz), Rio de Janeiro 21040-360, Brazil. Electronic address: lpinto@ioc.fiocruz.br., Ng A; Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 94720-3200, USA. Electronic address: arashng@berkeley.edu., Bhat S; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA., Zambrana JV; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address: josviczammad@gmail.com., D'Elia Zanella LGFAB; Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP 05403000, Brazil., Ho YL; Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP 05403000, Brazil. Electronic address: ho.yeh@hc.fm.usp.br., Romano CM; Departamento de Doenças Infecciosas e Parasitárias, Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP 05403000, Brazil; Laboratório de Investigação Médica, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP 05403000, Brazil. Electronic address: cmromano@usp.br., Beatty PR; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA; Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 94720-3200, USA. Electronic address: prbeatty@berkeley.edu., Biering SB; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA., Kallas EG; Departamento de Doenças Infecciosas e Parasitárias, Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP 05403000, Brazil; Laboratório de Investigação Médica, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP 05403000, Brazil; Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP 05403000, Brazil. Electronic address: esper.kallas@usp.br., Sabino EC; Departamento de Doenças Infecciosas e Parasitárias, Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP 05403000, Brazil; Laboratório de Investigação Médica, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP 05403000, Brazil. Electronic address: sabinoec@usp.br., Harris E; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA; Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 94720-3200, USA. Electronic address: eharris@berkeley.edu.

Publikováno v: EBioMedicine [EBioMedicine] 2024 Oct 24; Vol. 109, pp. 105409. Date of Electronic Publication: 2024 Oct 24.

Yellow fever disease severity and endothelial dysfunction are associated with elevated serum levels of viral NS1 protein and syndecan-1.

Autor: de Sousa FTG; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.; Departamento de Doenças Infecciosas e Parasitárias, Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, 05403000, Brazil., Warnes CM; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA., Manuli ER; Departamento de Doenças Infecciosas e Parasitárias, Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, 05403000, Brazil.; Laboratório de Investigação Médica, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo-SP, 05403000, Brazil., Ng A; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., D'Elia Zanella LGFAB; Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo-SP, 05403000, Brazil.; Instituto de Infectologia Emílio Ribas, São Paulo-SP, 01246-900, Brazil., Ho YL; Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo-SP, 05403000, Brazil., Bhat S; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA., Romano CM; Departamento de Doenças Infecciosas e Parasitárias, Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, 05403000, Brazil.; Laboratório de Investigação Médica, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo-SP, 05403000, Brazil., Beatty PR; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Biering SB; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA., Kallas EG; Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo-SP, 05403000, Brazil., Sabino EC; Departamento de Doenças Infecciosas e Parasitárias, Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, 05403000, Brazil.; Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo-SP, 05403000, Brazil., Harris E; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2023 Jun 30. Date of Electronic Publication: 2023 Jun 30.

SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling.

Autor: Biering SB; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA. sbiering@berkeley.edu., Gomes de Sousa FT; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA., Tjang LV; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA., Pahmeier F; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA., Zhu C; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Ruan R; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA., Blanc SF; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA., Patel TS; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA., Worthington CM; Chan Zuckerberg Biohub, San Francisco, CA, USA., Glasner DR; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.; UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, USA., Castillo-Rojas B; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA., Servellita V; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.; UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, USA., Lo NTN; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA., Wong MP; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA., Warnes CM; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA., Sandoval DR; Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA, USA., Clausen TM; Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA, USA., Santos YA; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.; UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, USA., Fox DM; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Ortega V; Department of Microbiology and Immunology, Cornell University, Ithaca, NY, USA., Näär AM; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Stanley SA; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Aguilar HC; Department of Microbiology and Immunology, Cornell University, Ithaca, NY, USA., Esko JD; Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA, USA., Chiu CY; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.; UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Pak JE; Chan Zuckerberg Biohub, San Francisco, CA, USA., Beatty PR; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Harris E; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA. eharris@berkeley.edu.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA. eharris@berkeley.edu.

Publikováno v: Nature communications [Nat Commun] 2022 Dec 09; Vol. 13 (1), pp. 7630. Date of Electronic Publication: 2022 Dec 09.

The Compound SBI-0090799 Inhibits Zika Virus Infection by Blocking De Novo Formation of the Membranous Replication Compartment.

Autor: Riva L; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA., Goellner S; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.; Division of Virus-Associated Carcinogenesis, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Center for Infection Research (DZIF), Heidelberg Partner Site, Heidelberg, Germany., Biering SB; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeleygrid.47840.3f, California, USA., Huang CT; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA., Rubanov AN; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA., Haselmann U; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.; German Center for Infection Research (DZIF), Heidelberg Partner Site, Heidelberg, Germany., Warnes CM; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeleygrid.47840.3f, California, USA., De Jesus PD; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA., Martin-Sancho L; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA., Terskikh AV; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA., Harris E; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeleygrid.47840.3f, California, USA., Pinkerton AB; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA., Bartenschlager R; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.; Division of Virus-Associated Carcinogenesis, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Center for Infection Research (DZIF), Heidelberg Partner Site, Heidelberg, Germany., Chanda SK; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.

Publikováno v: Journal of virology [J Virol] 2021 Oct 27; Vol. 95 (22), pp. e0099621. Date of Electronic Publication: 2021 Sep 01.

Avian anti-NS1 IgY antibodies neutralize dengue virus infection and protect against lethal dengue virus challenge.

Autor: O'Donnell KL; Department of Biomedical Sciences, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND, 58202, USA., Espinosa DA; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California Berkeley, Berkeley, CA, 94720, USA., Puerta-Guardo H; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California Berkeley, Berkeley, CA, 94720, USA., Biering SB; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California Berkeley, Berkeley, CA, 94720, USA., Warnes CM; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California Berkeley, Berkeley, CA, 94720, USA., Schiltz J; Avianax LLC, Grand Forks, ND, 58202, USA., Nilles ML; Department of Biomedical Sciences, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND, 58202, USA., Li J; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California Berkeley, Berkeley, CA, 94720, USA., Harris E; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California Berkeley, Berkeley, CA, 94720, USA., Bradley DS; Department of Biomedical Sciences, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND, 58202, USA. Electronic address: david.s.bradley@und.edu.

Publikováno v: Antiviral research [Antiviral Res] 2020 Nov; Vol. 183, pp. 104923. Date of Electronic Publication: 2020 Sep 23.