Bidirectional association between disturbed sleep and neuropathic pain symptoms: a prospective cohort study in post-total joint replacement participants

Autor: Stocks J, Tang NKY, Walsh DA, Warner SC, Harvey HL, Jenkins W, Abhishek A, Doherty M, Valdes AM

Publikováno v: Journal of Pain Research, Vol Volume 11, Pp 1087-1093 (2018)

Joanne Stocks,1–3 Nicole KY Tang,4 David A Walsh,1–3 Sophie C Warner,1 Hollie L Harvey,1 Wendy Jenkins,1 Abhishek Abhishek,1–3 Michael Doherty,1–3 Ana M Valdes1–3 1Academic Rheumatology, University of Nottingham, Nottingham, UK; 2Arthritis

Externí odkaz: https://doaj.org/article/6bbe5d1e487a4c428252fc57401c2b12

Community's Perception on Ambient Air and Noise Pollution: A Qualitative Study in Southwest Detroit.

Autor: Warner SC; Ms. Sydni C. Warner is a Project Manager at the JFM Consulting Group, Ann Arbor, Michigan, USA., Sagovac S; Ms. Simone Sagovac is a Project Director at the Southwest Detroit Community Benefits Coalition, Detroit, Michigan, USA., Godwin C; Dr. Christopher Godwin is a research specialist at the Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA., Xia T; Dr. Tian Xia is a post-doctoral fellow at the Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA., Batterman S; Dr. Stuart Batterman is a Professor at the Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.

Publikováno v: Environmental justice (Print) [Environ Justice] 2023 Aug 01; Vol. 16 (4), pp. 286-296. Date of Electronic Publication: 2023 Aug 01.

Noninvasive genomic profiling of somatic mutations in oral cavity cancers.

Autor: Xi Y; Department of Bioinformatics & Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Negrao MV; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Akagi K; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Xiao W; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Jiang B; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Warner SC; Genomics Shared Resource, The Ohio State University, Columbus, OH, United States., Dunn JD; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Wang J; Department of Bioinformatics & Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Symer DE; Department of Lymphoma & Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address: desymer@gmail.com., Gillison ML; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address: mgillison@mdanderson.org.

Publikováno v: Oral oncology [Oral Oncol] 2023 May; Vol. 140, pp. 106372. Date of Electronic Publication: 2023 Mar 31.

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.

Autor: Ramdas S; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Judd J; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Graham SE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI 48109, USA., Kanoni S; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK., Wang Y; Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Boston, MA 02118, USA., Surakka I; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI 48109, USA., Wenz B; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Clarke SL; VA Palo Alto Health Care Systems, Palo Alto, CA, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Chesi A; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wells A; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Bhatti KF; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK., Vedantam S; Endocrinology, Boston Childrens Hospital, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, 75 Ames street, Cambridge, MA 02142, USA., Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Locke AE; McDonnell Genome Institute and Department of Medicine, Washington University, St. Louis, MO 63108, USA., Marouli E; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK., Zajac GJM; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Wu KH; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Ntalla I; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ London, UK., Hui Q; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA; Atlanta VA Health Care System, Decatur, GA, USA., Klarin D; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, 75 Ames street, Cambridge, MA 02142, USA; Malcolm Randall VA Medical Center, Gainesville, FL, USA; Division of Vascular Surgery and Endovascular Therapy, University of Florida College of Medicine, Gainesville, FL, USA., Hilliard AT; VA Palo Alto Health Care Systems, Palo Alto, CA, USA., Wang Z; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA; Atlanta VA Health Care System, Decatur, GA, USA., Xue C; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI 48109, USA., Thorleifsson G; deCODE genetics/Amgen, Inc., Sturlugata 8, Reykjavik 102, Iceland., Helgadottir A; deCODE genetics/Amgen, Inc., Sturlugata 8, Reykjavik 102, Iceland., Gudbjartsson DF; deCODE genetics/Amgen, Inc., Sturlugata 8, Reykjavik 102, Iceland; School of Engineering and Natural Sciences, University of Iceland, Sæmundargötu 2, Reykjavik 102, Iceland., Holm H; deCODE genetics/Amgen, Inc., Sturlugata 8, Reykjavik 102, Iceland., Olafsson I; Department of Clinical Biochemistry, Landspitali - National University Hospital of Iceland, Hringbraut, Reykjavik 101, Iceland., Hwang MY; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungbuk, South Korea., Han S; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungbuk, South Korea., Akiyama M; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Sakaue S; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, The University of Tokyo, Tokyo, Japan; Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Terao C; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Kanai M; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, 75 Ames street, Cambridge, MA 02142, USA; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Zhou W; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, 75 Ames street, Cambridge, MA 02142, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Brumpton BM; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, BS8 2BN Bristol, UK; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Rasheed H; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, BS8 2BN Bristol, UK; Division of Medicine and Laboratory Sciences, University of Oslo, Oslo, Norway., Havulinna AS; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014 Helsinki, Finland; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Veturi Y; Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA., Pacheco JA; Center for Genetic Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA., Rosenthal EA; Department of Medicine (Medical Genetics), University of Washington, Seattle, WA, USA., Lingren T; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Feng Q; Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Kullo IJ; Department of Cardiovascular Medicine and the Gonda Vascular Center, Mayo Clinic, Rochester, MN, USA., Narita A; Tohoku Medical Megabank Organization, Tohoku University, Sendai 980-8573, Japan., Takayama J; Tohoku Medical Megabank Organization, Tohoku University, Sendai 980-8573, Japan., Martin HC; Wellcome Trust Sanger Institute, CB10 1SA Hinxton, UK., Hunt KA; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Trivedi B; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Haessler J; Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA 98109, USA., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA., Bradford Y; Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA., Miller JE; Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, EH4 2XU Edinburgh, UK; Usher Institute, The University of Edinburgh, Nine, Edinburgh Bioquarter, 9 Little France Road, EH16 4UX Edinburgh, UK., Lin K; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, OX3 7LF Oxford, UK., Millwood IY; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, OX3 7LF Oxford, UK; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, OX3 7LF Oxford, UK., Rasheed A; Center for Non-Communicable Diseases, Karachi, SD, Pakistan & Faisalabad Institute of Cardiology, Faislabad, Pakistan., Hindy G; Department of Population Medicine, Qatar University College of Medicine, QU Health, Doha, Qatar., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, USA., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, USA., Turman C; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA., Huang H; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA., Graff M; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Choudhury A; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Sengupta D; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Brown MR; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Zhang W; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, W2 1PG London, UK; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, UB1 3HW Middlesex, UK; Imperial College Healthcare NHS Trust, Imperial College London, W12 0HS London, UK., Yu K; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Schmidt EM; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Pandit A; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Gustafsson S; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Yin X; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, CB2 0QQ Cambridge, UK., Zhao JH; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, CB1 8RN Cambridge, UK., Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Jang HM; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungbuk, South Korea., Yoon K; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungbuk, South Korea., Medina-Gomez C; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Pitsillides A; Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Boston, MA 02118, USA., Hottenga JJ; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, EX2 5DW Exeter, UK., Ji Y; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, EX2 5DW Exeter, UK., Gao Z; Department of Clinical Acupuncture and Moxibustion, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Haworth S; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, BS8 2BN Bristol, UK; Bristol Dental School, University of Bristol, Lower Maudlin Street, BS1 2LY Bristol, UK., Mitchell RE; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, BS8 2BN Bristol, UK; Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield Grove, BS8 2BN Bristol, UK., Chai JF; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore., Aadahl M; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bjerregaard AA; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA 90502, USA., Manichaikul A; Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22903, USA., Lee WJ; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan; No. 1650, Sec. 4, Taiwan Boulevard, Taichung City 40705, Taiwan., Hsiung CA; Institute of Population Health Sciences, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan, ROC., Warren HR; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ London, UK., Ramirez J; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK., Bork-Jensen J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kårhus LL; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Goel A; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, OX3 9DU Oxford, UK., Sabater-Lleal M; Unit of Genomics of Complex Diseases. Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Mauro P; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Rome, Italy., Matteo F; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Rome, Italy; Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sardinia, Italy., McDaid AF; University Center for Primary Care and Public Health, University of Lausanne, Rte de Berne 113, 1010 Lausanne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland., Marques-Vidal P; Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, 1011 Lausanne, Switzerland., Wielscher M; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, W2 1PG London, UK., Trompet S; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands., Sattar N; BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, UK., Møllehave LT; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Munz M; Institute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research), partner site Hamburg/Lübeck/Kiel, University Heart Center Lübeck, Lübeck and Charité - University Medicine Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute for Dental and Craniofacial Sciences, Department of Periodontology and Synoptic Dentistry, Berlin, Germany., Zeng L; Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, Munich, Germany; Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) e.V., partner site Munich Heart Alliance, Munich, Germany., Huang J; Key Laboratory of Cardiovascular Epidemiology & Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China., Yang B; Key Laboratory of Cardiovascular Epidemiology & Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China., Poveda A; Lund University Diabetes Centre, Lunds University, Malmö, Sweden., Kurbasic A; Lund University Diabetes Centre, Lunds University, Malmö, Sweden., Schönherr S; Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria and German Chronic Kidney Disease Study, Austria., Forer L; Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria and German Chronic Kidney Disease Study, Austria., Scholz M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, 04107 Leipzig, Germany; LIFE Research Centre for Civilization Diseases, University of Leipzig, Philipp-Rosenthal-Straße 27, 04103 Leipzig, Germany., Galesloot TE; Radboud university medical center, Radboud Institute for Health Sciences, Nijmegen, the Netherlands., Bradfield JP; Quantinuum Research LLC, Wayne, PA 19087, USA., Ruotsalainen SE; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014 Helsinki, Finland., Daw EW; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Zmuda JM; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15232, USA., Mitchell JS; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, 39100 Bolzano, Italy., Fuchsberger C; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, 39100 Bolzano, Italy., Christensen H; Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA., Le P; Department of Anthropology, University of Toronto at Mississauga, Mississauga, ON L5L 1C6, Canada; Department of Computer Science, University of Toronto, Toronto, ON M5S 2E4, Canada., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Wojczynski MK; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Hemerich D; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Preuss M; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, SE1 7EH London, UK; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, SE1 9RT London, UK., Christofidou P; Department of Twin Research and Genetic Epidemiology, King's College London, SE1 7EH London, UK., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700RB Groningen, the Netherlands., Benjamins JW; Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700RB Groningen, the Netherlands., Engmann J; Institute of Cardiovascular Sciences, University College London, Gower Street, WC1E 6BT London, UK; Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, WC1E 6BT London, UK., Noah TL; Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA., Verma A; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Slieker RC; Amsterdam UMC, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam 1081HV, the Netherlands; Leiden University Medical Center, Department of Cell and Chemical Biology, Leiden 2333ZA, the Netherlands., Lo KS; Montreal Heart Institute, Université de Montréal, 5000 Belanger street, Montreal, QC H1T1C8, Canada., Zilhao NR; Icelandic Heart Association, 201 Kopavogur, Iceland., Kleber ME; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany; SYNLAB MVZ Humangenetik Mannheim GmbH, 68163 Mannheim, Germany., Delgado GE; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany., Huo S; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Ikeda DD; Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan., Iha H; Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan., Yang J; School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310024, China; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia., Liu J; Nuffield Department of Population Health, University of Oxford, Oxford, UK; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands., Demirkan A; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands; Section of Statistical Multi-omics, Department of Clinical and Experimental research, University of Surrey, Guildford, Surrey, UK., Leonard HL; Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, MD, USA; Data Tecnica International, Glen Echo, MD, USA., Marten J; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK., Emmel C; Institute for Medical Informatics, Biometrie and Epidemiology, University of Duisburg-Essen, Essen, Germany., Schmidt B; Institute for Medical Informatics, Biometrie and Epidemiology, University of Duisburg-Essen, Essen, Germany., Smyth LJ; Centre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland., Cañadas-Garre M; Centre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland; Genomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer-University of Granada-Andalusian Regional Government, Granada, Spain; Hematology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain; Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain., Wang C; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Nakatochi M; Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya 461-8673, Japan., Wong A; University of Alabama at Birmingham, Epidemiology, School of Public Health, Birmingham, AL, USA., Hutri-Kähönen N; Tampere Centre for Skills Training and Simulation, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Sim X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore., Xia R; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston TX 77030, USA., Huerta-Chagoya A; CONACYT, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de Mexico, Mexico., Fernandez-Lopez JC; Departamento de Genómica Computacional, Instituto Nacional de Medicina Genómica, Ciudad de Mexico, Mexico., Lyssenko V; Lund University Diabetes Centre, Lunds University, Malmö, Sweden; Center for diabetes research, University of Bergen, Bergen, Norway., Nongmaithem SS; Genomic Research on Complex diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Telangana, India., Sankareswaran A; Genomic Research on Complex diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Telangana, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-Human Resource Development Centre, New Delhi, India., Irvin MR; University of Alabama at Birmingham, Epidemiology, School of Public Health, Birmingham, AL, USA., Oldmeadow C; Hunter Medical Research Institute, Newcastle, NSW, Australia., Kim HN; Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea; Department of Clinical Research Design & Evaluation, SAIHST, Sungkyunkwan University, Seoul 06355, Korea., Ryu S; Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 04514, Korea; Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea., Timmers PRHJ; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Arbeeva L; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA., Dorajoo R; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore; Health Services and Systems Research, Duke-NUS Medical School, 169857, Singapore., Lange LA; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, Anschutz Medical Campus, University of Colorado, Denver, Aurora, CO 80045, USA., Prasad G; Academy of Scientific and Innovative Research (AcSIR), CSIR-Human Resource Development Centre, New Delhi, India; Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi 110020, India., Lorés-Motta L; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Philips van Leydenlaan 15, Nijmegen 6525 EX, the Netherlands., Pauper M; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Philips van Leydenlaan 15, Nijmegen 6525 EX, the Netherlands., Long J; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA., Li X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA 90502, USA., Theusch E; Department of Pediatrics, University of California San Francisco, Oakland, CA 94609, USA., Takeuchi F; National Center for Global Health and Medicine, Tokyo 1628655, Japan., Spracklen CN; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Biostatistics and Epidemiology, University of Massachusetts-Amherst, Amherst, MA 01003, USA., Loukola A; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014 Helsinki, Finland., Bollepalli S; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014 Helsinki, Finland., Warner SC; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Wang YX; Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, 17 Hougou Lane, Chong Wen Men, Beijing 100005, China., Wei WB; Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 1 Dong Jiao Min Xiang, Dong Cheng District, Beijing 100730, China., Nutile T; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' - CNR, Naples, Italy., Ruggiero D; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' - CNR, Naples, Italy; IRCCS Neuromed, Pozzilli, Isernia, Italy., Sung YJ; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA., Chen S; Key Laboratory of Cardiovascular Epidemiology & Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China., Liu F; Key Laboratory of Cardiovascular Epidemiology & Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China., Yang J; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Kentistou KA; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Banas B; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany., Morgan A; Institute for Maternal and Child Health-IRCCS, Burlo Garofolo, 34127 Trieste, Italy., Meidtner K; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA., Smith JA; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, USA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA., Hebbar P; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait., Farmaki AE; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Eleftheriou Venizelou, Athens, Greece; Department of Population Science and Experimental Medicine, University College London, London, UK., Hofer E; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria., Lin M; Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA., Concas MP; Institute for Maternal and Child Health-IRCCS, Burlo Garofolo, 34127 Trieste, Italy., Vaccargiu S; Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Sassari, Italy., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands., Pitkänen N; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland., Cade BE; Sleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA., van der Laan SW; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Chitrala KN; Laboratory of Epidemiology and Population Science National Institute on Aging Intramural Research Program, NIH 251 Bayview Blvd, NIH Biomedical Research Center, Baltimore, MD 21224, USA; Fels Cancer Institute for Personalized Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA., Weiss S; Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University of Greifswald and University Medicine Greifswald, Greifswald, Germany., Bentley AR; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 4047, Bethesda, MD 20892, USA., Doumatey AP; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 4047, Bethesda, MD 20892, USA., Adeyemo AA; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 4047, Bethesda, MD 20892, USA., Lee JY; Oneomics. co. ltd. 2F, Soonchunhyang Mirai Medical Center 173, Buheuyng-ro, Bucheon-si Gyeonggi-do 14585, Korea., Petersen ERB; Department of Clinical Biochemistry and Immunology, Hospital of Southern Jutland, Kresten Philipsens Vej 15, 6200 Aabenraa, Denmark., Nielsen AA; Department of Clinical Biochemistry, Lillebaelt Hospital, Kolding, Denmark., Choi HS; Department of Biomedical Science, Hallym University, Chuncheon, Gangwon 24252, Korea., Nethander M; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Freitag-Wolf S; Institute of Medical Informatics and Statistics, Kiel University, Kiel, Germany., Southam L; Wellcome Trust Sanger Institute, CB10 1SA Hinxton, UK; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Rayner NW; Wellcome Trust Sanger Institute, CB10 1SA Hinxton, UK; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, UK., Wang CA; School of Medicine and Public Health, Faculty of Medicine and Health, University of Newcastle, Newcastle, NSW 2308, Australia., Lin SY; Center for Geriatrics and Gerontology, Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan; School of Medicine, National Defense Medical Center, Taipei, Taiwan., Wang JS; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan., Couture C; Department of Kinesiology, Université Laval, Quebec City, QC, Canada., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, 33520 Tampere, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland., Nikus K; Department of Cardiology, Heart Center, Tampere University Hospital, 33521 Tampere, Finland; Department of Cardiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland., Cuellar-Partida G; University of Queensland Diamantina Institute, Translational Research Institute, Kent St, Woolloongabba, Brisbane, QLD 4102, Australia., Vestergaard H; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Medicine, Bornholms Hospital, Rønne, Denmark., Hidalgo B; School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Giannakopoulou O; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK., Cai Q; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA., Obura MO; Amsterdam UMC, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam 1081HV, the Netherlands., van Setten J; Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., He KY; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA., Tang H; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Terzikhan N; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands., Shin JH; Department of Biomedical Science, Hallym University, Chuncheon, Gangwon 24252, Korea., Jackson RD; Ohio State University, Division of Endricinology, Columbus, OH 43210, USA., Reiner AP; University of Washington, Department of Epidemiology, Seattle, WA 98195, USA., Martin LW; George Washington University, School of Medicine and Health Sciences, Washington, DC 20037, USA., Chen Z; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, OX3 7LF Oxford, UK; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, OX3 7LF Oxford, UK., Li L; Department of Epidemiology, School of Public Health, Peking University Health Science Center, Beijing, China., Kawaguchi T; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Thiery J; LIFE Research Centre for Civilization Diseases, University of Leipzig, Philipp-Rosenthal-Straße 27, 04103 Leipzig, Germany; Institute for Laboratory Medicine, University Hospital Leipzig, Paul-List-Strasse 13/15, 04103 Leipzig, Germany., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research Program, NIH, Baltimore, MD 20892-9205, USA., Li H; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, MD, USA; Data Tecnica International, Glen Echo, MD, USA., Raitakari OT; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland., Ichihara S; Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke 329-0498, Japan., Wild SH; Centre for Population Health Sciences, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Campbell H; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Jäger S; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany., Nabika T; Department of Functional Pathology, Shimane University School of Medicine, Izumo 6938501, Japan., Al-Mulla F; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait., Niinikoski H; Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland; Department of Physiology, University of Turku, Turku, Finland., Braund PS; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Kolcic I; Faculty of Medicine, University of Split, Šoltanska 2, 21000 Split, Croatia., Kovacs P; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Liebigstr. 21, 04103 Leipzig, Germany., Giardoglou T; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Eleftheriou Venizelou, Athens, Greece., Katsuya T; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita 5650871, Japan; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita 5650871, Japan., de Kleijn D; Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., de Borst GJ; Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Kim EK; Corneal Dystrophy Research Institute, Department of Ophthalmology, Yonsei University College of Medicine, Seoul 03722, Korea., Adams HHH; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands., Ikram MA; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands., Zhu X; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA., Asselbergs FW; Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Kraaijeveld AO; Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Beulens JWJ; Amsterdam UMC, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam 1081HV, the Netherlands; Julius Centre for Health Sciences and Primary Care, University Medical Ceslrntre Utrecht, Utrecht 3584CG, the Netherlands., Shu XO; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA., Rallidis LS; Second Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Mitchell P; Center for Vision Research, Department of Ophthalmology and The Westmead Institute, University of Sydney, Hawkesbury Rd, Sydney, NSW 2145, Australia., Hewitt AW; Menzies Institute for Medical Research, School of Medicine, University of Tasmania, Liverpool St, Hobart, TAS 7000, Australia; Centre for Eye Research Australia, University of Melbourne, Melbourne, VIC 3002, Australia., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, 33521 Tampere, Finland; Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland., Pérusse L; Department of Kinesiology, Université Laval, Quebec City, QC, Canada; Centre Nutrition, santé et société (NUTRISS), Institute of Nutrition and Functional Foods (INAF), Quebec, QC, Canada., Bouchard C; Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA., Tönjes A; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Liebigstr. 21, 04103 Leipzig, Germany., Ida Chen YD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA 90502, USA., Pennell CE; School of Medicine and Public Health, Faculty of Medicine and Health, University of Newcastle, Newcastle, NSW 2308, Australia., Mori TA; Discipline of Internal Medicine, Medical School, The University of Western Australia, Perth, WA, Australia., Lieb W; Institute of Epidemiology, Kiel University, Kiel, Germany., Franke A; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany., Ohlsson C; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Sahlgrenska University Hospital, Department of Drug Treatment, Gothenburg, Sweden., Mellström D; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Geriatric Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Cho YS; Department of Biomedical Science, Hallym University, Chuncheon, Gangwon 24252, Korea., Lee H; Department of Internal Medicine, EwhaWomans University School of Medicine, Seoul, Korea., Yuan JM; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15232, USA; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA., Koh WP; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A∗STAR), Singapore 117609, Singapore., Rhee SY; Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul 02447, Korea., Woo JT; Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul 02447, Korea., Heid IM; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Stark KJ; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Zimmermann ME; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Völzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Homuth G; Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University of Greifswald and University Medicine Greifswald, Greifswald, Germany., Evans MK; Laboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research Program, NIH, Baltimore, MD 20892-9205, USA., Zonderman AB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research Program, NIH, Baltimore, MD 20892-9205, USA., Polasek O; Faculty of Medicine, University of Split, Šoltanska 2, 21000 Split, Croatia; Algebra University College, Ilica 242, Zagreb, Croatia., Pasterkamp G; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Hoefer IE; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Redline S; Sleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA., Pahkala K; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland; Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, Turku, Finland., Oldehinkel AJ; Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands., Biino G; Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy., Schmidt R; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria., Schmidt H; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria., Bandinelli S; Local Health Unit Toscana Centro, Firenze, Italy., Dedoussis G; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Eleftheriou Venizelou, Athens, Greece., Thanaraj TA; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA., Kato N; National Center for Global Health and Medicine, Tokyo 1628655, Japan., Schulze MB; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany., Girotto G; Institute for Maternal and Child Health-IRCCS, Burlo Garofolo, 34127 Trieste, Italy; Department of Medicine, Surgery and Health Sciences, University of Trieste, Strada di Fiume 447, 34149 Trieste, Italy., Böger CA; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany; Department of Nephrology, Diabetology, Rheumatology, Traunstein Hospital, Traunstein, Germany; KfH Kidney Center Traunstein, Traunstein, Germany., Jung B; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany; Department of Nephrology, Diabetology, Rheumatology, Traunstein Hospital, Traunstein, Germany; KfH Kidney Center Traunstein, Traunstein, Germany., Joshi PK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., De Jager PL; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, 75 Ames street, Cambridge, MA 02142, USA; Center for Translational and Systems Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA., Lu X; Key Laboratory of Cardiovascular Epidemiology & Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China., Mamakou V; Medical School, National and Kapodistrian University Athens, 75 M. Assias Street, 115 27 Athens, Greece; Dromokaiteio Psychiatric Hospital, 124 61 Athens, Greece., Brown M; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ London, UK; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ London, UK., Caulfield MJ; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ London, UK., Munroe PB; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ London, UK., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA 90502, USA., Ciullo M; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' - CNR, Naples, Italy; IRCCS Neuromed, Pozzilli, Isernia, Italy., Jonas JB; Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, 17 Hougou Lane, Chong Wen Men, Beijing 100005, China; Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Kutzerufer 1, Mannheim 68167, Germany; Institute of Molecular and Clinical Ophthalmology, Basel, Switzerland; Privatpraxis Prof Jonas und Dr Panda-Jonas, Heidelberg, Germany., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Kaprio J; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014 Helsinki, Finland., Pajukanta P; Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA, USA., Tusié-Luna T; Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico; Instituto de Investigaciones Biomédicas, UNAM, Mexico City, Mexico., Aguilar-Salinas CA; Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico; Dirección de Nutrición and Unidad de Estudios de Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Adair LS; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA; Carolina Population Center, University of North Carolina, Chapel Hill, NC 27516, USA., Bechayda SA; USC-Office of Population Studies Foundation, University of San Carlos, Cebu City 6000, Philippines; Department of Anthropology, Sociology, and History, University of San Carlos, Cebu City 6000, Philippines., de Silva HJ; Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama 11010, Sri Lanka., Wickremasinghe AR; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama 11010, Sri Lanka., Krauss RM; Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA., Wu JY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Zheng W; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA., den Hollander AI; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Philips van Leydenlaan 15, Nijmegen 6525 EX, the Netherlands., Bharadwaj D; Academy of Scientific and Innovative Research (AcSIR), CSIR-Human Resource Development Centre, New Delhi, India; Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Heng CK; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore; and Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore., Nelson AE; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA; Department of Medicine, University of North Carolina, Chapel Hill, NC, USA., Golightly YM; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA; Injury Prevention Research Center, University of North Carolina, Chapel Hill, NC, USA; Division of Physical Therapy, University of North Carolina, Chapel Hill, NC, USA., Wilson JF; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Penninx B; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Amsterdam Public Health Research Institute, VU Medical Center Amsterdam, Amsterdam, the Netherlands., Kim HL; Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul 07804, Korea., Attia J; Hunter Medical Research Institute, Newcastle, NSW, Australia; School of Medicine and Public Health, Faculty of Medicine and Health, University of Newcastle, Newcastle, NSW 2308, Australia., Scott RJ; Hunter Medical Research Institute, Newcastle, NSW, Australia; School of Medicine and Public Health, Faculty of Medicine and Health, University of Newcastle, Newcastle, NSW 2308, Australia., Rao DC; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA., Arnett DK; University of Kentucky, College of Public Health, Lexington, KY, USA., Walker M; Institute of Cellular Medicine (Diabetes), The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK., Scott LJ; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Koistinen HA; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland; University of Helsinki and Department of Medicine, Helsinki University Hospital, P.O.Box 340, Haartmaninkatu 4, 00029 Helsinki, Finland; Minerva Foundation Institute for Medical Research, Biomedicum 2U, Tukholmankatu 8, 00290 Helsinki, Finland., Chandak GR; Genomic Research on Complex diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Telangana, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-Human Resource Development Centre, New Delhi, India; JSS Academy of Higher Education and Research, Mysuru, India., Mercader JM; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA 02115, USA., Villalpando CG; Instituto Nacional de Salud Publica y Centro de Estudios en Diabetes, Cuernavaca, Morelos, Mexico., Orozco L; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Fornage M; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston TX 77030, USA; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Tai ES; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore 119228, Singapore., van Dam RM; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore 119228, Singapore., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, 33520 Tampere, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland., Chaturvedi N; MRC Unit for Lifelong Health and Ageing at UCL, 1-19 Torrington Place, WC1E 7HB London, UK., Yokota M; Kurume University School of Medicine, Kurume 830-0011, Japan., Liu J; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Reilly DF; Genetics, Merck Sharp & Dohme Corp, Kenilworth, NJ 07033, USA., McKnight AJ; Centre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland., Kee F; Centre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland., Jöckel KH; Institute for Medical Informatics, Biometrie and Epidemiology, University of Duisburg-Essen, Essen, Germany., McCarthy MI; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, UK., Palmer CNA; Division of Population Health and Genomics, University of Dundee, Ninwells Hospital and Medical School, Dundee DD1 9SY, UK., Vitart V; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK., Simonsick E; Intramural Research Program, National Institute on Aging, 3001 S. Hanover St., Baltimore, MD 21225, USA., van Duijn CM; Nuffield Department of Population Health, University of Oxford, Oxford, UK; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands., Jin ZB; Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 1 Dong Jiao Min Xiang, Dong Cheng District, Beijing 100730, China; The Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China., Lu F; The Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China., Hishigaki H; Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan., Lin X; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., März W; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany; Synlab Academy, SYNLAB Holding Deutschland GmbH, Mannheim and Augsburg, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria., Gudnason V; Icelandic Heart Association, 201 Kopavogur, Iceland; Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland., Tardif JC; Montreal Heart Institute, Université de Montréal, 5000 Belanger street, Montreal, QC H1T1C8, Canada., Lettre G; Montreal Heart Institute, Université de Montréal, 5000 Belanger street, Montreal, QC H1T1C8, Canada., T Hart LM; Amsterdam UMC, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam 1081HV, the Netherlands; Leiden University Medical Center, Department of Cell and Chemical Biology, Leiden 2333ZA, the Netherlands; Leiden University Medical Center, Department of Biomedical Data Sciences, Section Molecular Epidemiology, 2333ZA Leiden, the Netherlands., Elders PJM; Amsterdam UMC, Department of General Practice and Elderly Care, Amsterdam Public Health Research Institute, 1081HV Amsterdam, the Netherlands., Rader DJ; Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Damrauer SM; Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA 19104, USA., Kumari M; Institute of Social and Economic Research, University of Essex, Wivenhoe Park CO4 3SQ, UK., Kivimaki M; Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, WC1E 6BT London, UK., van der Harst P; Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700RB Groningen, the Netherlands., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, SE1 7EH London, UK., Loos RJF; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Province MA; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Parra EJ; Department of Anthropology, University of Toronto at Mississauga, Mississauga, ON L5L 1C6, Canada., Cruz M; Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA; University of Washington, Department of Epidemiology, Seattle, WA 98195, USA; Department of Health Services, University of Washington, Seattle, WA, USA., Brandslund I; Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark., Pramstaller PP; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, 39100 Bolzano, Italy., Rotimi CN; 16Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 4047, Bethesda, MD 20892, USA., Christensen K; Danish Aging Research Center, University of Southern Denmark, Odense C, Denmark., Ripatti S; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014 Helsinki, Finland; Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Widén E; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014 Helsinki, Finland., Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Grant SFA; Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Kiemeney L; Radboud university medical center, Radboud Institute for Health Sciences, Nijmegen, the Netherlands., de Graaf J; Radboud university medical center, Radboud Institute for Health Sciences, Nijmegen, the Netherlands., Loeffler M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, 04107 Leipzig, Germany; LIFE Research Centre for Civilization Diseases, University of Leipzig, Philipp-Rosenthal-Straße 27, 04103 Leipzig, Germany., Kronenberg F; Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria and German Chronic Kidney Disease Study, Austria., Gu D; Key Laboratory of Cardiovascular Epidemiology & Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China; School of Medicine, Southern University of Science and Technology, Shenzhen, China., Erdmann J; Institute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research), partner site Hamburg/Lübeck/Kiel, University Heart Center Lübeck, Lübeck and Charité - University Medicine Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute for Dental and Craniofacial Sciences, Department of Periodontology and Synoptic Dentistry, Berlin, Germany., Schunkert H; Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, Munich, Germany; Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) e.V., partner site Munich Heart Alliance, Munich, Germany., Franks PW; Lund University Diabetes Centre, Lunds University, Malmö, Sweden., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands; Netherlands Heart Institute, Utrecht, the Netherlands., Khera AV; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, 75 Ames street, Cambridge, MA 02142, USA; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Northern Finland Birth Cohorts, Infrastructure for population studies, Faculty of Medicine, University of Oulu, Oulu, Finland., Männikkö M; Northern Finland Birth Cohorts, Infrastructure for population studies, Faculty of Medicine, University of Oulu, Oulu, Finland., Jarvelin MR; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, W2 1PG London, UK; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland; Biocenter of Oulu, University of Oulu, Oulu, Finland., Kutalik Z; University Center for Primary Care and Public Health, University of Lausanne, Rte de Berne 113, 1010 Lausanne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland., Francesco C; Institute for Genetic and Biomedical Research, Italian National Council of Research (IRGB CNR), Cagliari, Italy; University of Sassari, Sassari, Italy., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands., Willems van Dijk K; Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands., Watkins H; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, OX3 9DU Oxford, UK; Unit of Genomics of Complex Diseases. Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain., Strachan DP; Population Health Research Institute, St George's, University of London, SW17 0RE London, UK., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Sever P; National Heart and Lung Institute, Imperial College London, W2 1PG London, UK., Poulter N; School of Public Health, Imperial College London, W12 7RH London, UK., Huey-Herng Sheu W; Taichung Veterans General Hospital, Taichung, Taiwan; No. 1650, Sec. 4, Taiwan Boulevard, Xitun District Taichung City 40705, Taiwan; Division of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; No. 201, Sec. 2, Shipai Road, Beitou District, Taipei City 112201, Taiwan., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA 90502, USA., Dantoft TM; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Karpe F; OCDEM, University of Oxford, Churchill Hospital, OX3 7LE Oxford, UK; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK., Neville MJ; OCDEM, University of Oxford, Churchill Hospital, OX3 7LE Oxford, UK; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK., Timpson NJ; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, BS8 2BN Bristol, UK; Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield Grove, BS8 2BN Bristol, UK., Cheng CY; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore 169857, Singapore., Wong TY; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore 169857, Singapore., Khor CC; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Li H; Data Science, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore., Sabanayagam C; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore 169857, Singapore., Peters A; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) e.V., partner site Munich Heart Alliance, Munich, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany., Gieger C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany., Hattersley AT; University of Exeter Medical School, University of Exeter, EX2 5DW Exeter, UK., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Boomsma DI; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Amsterdam Public Health Research Institute, VU Medical Center Amsterdam, Amsterdam, the Netherlands., de Geus EJC; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Amsterdam Public Health Research Institute, VU Medical Center Amsterdam, Amsterdam, the Netherlands., Cupples LA; Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Boston, MA 02118, USA; Framingham Heart Study, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, MD, USA., van Meurs JBJ; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands., Ikram A; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands., Ghanbari M; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands; Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Gordon-Larsen P; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA; Carolina Population Center, University of North Carolina, Chapel Hill, NC 27516, USA., Huang W; Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai 201203, China., Kim YJ; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungbuk, South Korea., Tabara Y; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, CB2 0QQ Cambridge, UK., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, CB2 0QQ Cambridge, UK., Zeggini E; Wellcome Trust Sanger Institute, CB10 1SA Hinxton, UK; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Technical University of Munich (TUM) and Klinikum Rechts der Isar, TUM School of Medicine, Munich, Germany., Tuomilehto J; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland; Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Ingelsson E; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Stanford Cardiovascular Institute, Stanford University, Stanford, CA 94305, USA; Stanford Diabetes Research Center, Stanford University, Stanford, CA 94305, USA., Abecasis G; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Chambers JC; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, W2 1PG London, UK; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, UB1 3HW Middlesex, UK; Imperial College Healthcare NHS Trust, Imperial College London, W12 0HS London, UK; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore., Kooner JS; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, UB1 3HW Middlesex, UK; Imperial College Healthcare NHS Trust, Imperial College London, W12 0HS London, UK; National Heart and Lung Institute, Imperial College London, W2 1PG London, UK; MRC-PHE Centre for Environment and Health, Imperial College London, London W2 1PG, UK., de Vries PS; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Hazelhurst S; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; School of Electrical & Information Engineering, University of the Witwatersrand, Witwatersrand, South Africa., Ramsay M; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., North KE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Daviglus M; Institute for Minority Health Research, University of Illinois College of Medicine, Chicago, IL, USA., Kraft P; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA., Martin NG; QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD 4006, Australia., Whitfield JB; QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD 4006, Australia., Abbas S; Center for Non-Communicable Diseases, Karachi, SD, Pakistan & Faisalabad Institute of Cardiology, Faislabad, Pakistan., Saleheen D; Center for Non-Communicable Diseases, Karachi, SD, Pakistan & Faisalabad Institute of Cardiology, Faislabad, Pakistan; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA; Department of Cardiology, Columbia University Irving Medical Center, New York, NY, USA., Walters RG; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, OX3 7LF Oxford, UK; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, OX3 7LF Oxford, UK; Big Data Instutute, University of Oxford, OX3 7LF Oxford, UK., Holmes MV; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, OX3 7LF Oxford, UK; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, OX3 7LF Oxford, UK; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK., Black C; Aberdeen Centre for Health Data Science,1:042 Polwarth Building School of Medicine, Medical Science and Nutrition University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK., Smith BH; Division of Population Health and Genomics, University of Dundee, Ninwells Hospital and Medical School, Dundee DD1 9SY, UK., Baras A; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Justice AE; Biomedical and Translational Informatics, Geisinger Health, Danville, PA 17822, USA., Buring JE; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA., Kooperberg C; Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA 98109, USA., Tamiya G; Tohoku Medical Megabank Organization, Tohoku University, Sendai 980-8573, Japan., Yamamoto M; Tohoku Medical Megabank Organization, Tohoku University, Sendai 980-8573, Japan., van Heel DA; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Trembath RC; School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London, UK., Wei WQ; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Jarvik GP; Departments of Medicine (Medical Genetics) and Genome Sciences, University of Washington, Seattle, WA, USA., Namjou B; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA., Hayes MG; Center for Genetic Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA; Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Anthropology, Northwestern University, Evanston, IL 60208, USA., Ritchie MD; Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA., Jousilahti P; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Salomaa V; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Hveem K; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger 7600, Norway; Department of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger 7600, Norway., Åsvold BO; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger 7600, Norway; Department of Endocrinology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Kubo M; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Kamatani Y; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Okada Y; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan; Laboratory of Statistical Immunology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan., Murakami Y; Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Kim BJ; Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, South Korea., Thorsteinsdottir U; deCODE genetics/Amgen, Inc., Sturlugata 8, Reykjavik 102, Iceland; Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland., Stefansson K; deCODE genetics/Amgen, Inc., Sturlugata 8, Reykjavik 102, Iceland; Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland., Zhang J; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI 48109, USA., Chen YE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI 48109, USA., Ho YL; VA Boston Healthcare System, Boston, MA, USA., Lynch JA; VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, USA; University of Massachusetts, Boston, MA, USA., Tsao PS; VA Palo Alto Health Care Systems, Palo Alto, CA, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA., Chang KM; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA 19104, USA; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Cho K; VA Boston Healthcare System, Boston, MA, USA; Department of Medicine, Brigham Women's Hospital, Boston, MA, USA., O'Donnell CJ; VA Boston Healthcare System, Boston, MA, USA; Department of Medicine, Brigham Women's Hospital, Boston, MA, USA., Gaziano JM; VA Boston Healthcare System, Boston, MA, USA; Department of Medicine, Brigham Women's Hospital, Boston, MA, USA., Wilson P; Atlanta VA Health Care System, Decatur, GA, USA; Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, EX2 5DW Exeter, UK., Hirschhorn JN; Endocrinology, Boston Childrens Hospital, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, 75 Ames street, Cambridge, MA 02142, USA; Departments of Pediatrics and Genetics, Harvard Medical School, Boston, MA, USA., Kathiresan S; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, 75 Ames street, Cambridge, MA 02142, USA; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA., Boehnke M; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Struan Grant; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Natarajan P; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, 75 Ames street, Cambridge, MA 02142, USA; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Sun YV; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA; Atlanta VA Health Care System, Decatur, GA, USA., Morris AP; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester, UK., Deloukas P; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia., Peloso G; Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Boston, MA 02118, USA., Assimes TL; VA Palo Alto Health Care Systems, Palo Alto, CA, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA., Willer CJ; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA., Zhu X; VA Palo Alto Health Care Systems, Palo Alto, CA, USA; Department of Statistics, The Pennsylvania State University, University Park, PA, USA; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA; Department of Statistics, Stanford University, Stanford, CA, USA. Electronic address: xiangzhu@psu.edu., Brown CD; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: chrbro@upenn.edu.

Publikováno v: American journal of human genetics [Am J Hum Genet] 2022 Aug 04; Vol. 109 (8), pp. 1366-1387.

The power of genetic diversity in genome-wide association studies of lipids.

Autor: Graham SE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Clarke SL; VA Palo Alto Health Care System, Palo Alto, CA, USA.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA., Wu KH; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Kanoni S; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Zajac GJM; Department of Biostatistics and Center for Statistics Genetics, University of Michigan, Ann Arbor, MI, USA., Ramdas S; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Surakka I; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Ntalla I; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Vedantam S; Endocrinology, Boston Children's Hospital, Boston, MA, USA.; Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Locke AE; McDonnell Genome Institute and Department of Medicine, Washington University, St Louis, MO, USA., Marouli E; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Hwang MY; Department of Precision Medicine, Division of Genome Science, National Institute of Health, Cheongju-si, South Korea., Han S; Department of Precision Medicine, Division of Genome Science, National Institute of Health, Cheongju-si, South Korea., Narita A; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Choudhury A; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Bentley AR; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Ekoru K; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Verma A; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Trivedi B; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Martin HC; Wellcome Sanger Institute, Hinxton, UK., Hunt KA; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Hui Q; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.; Atlanta VA Health Care System, Decatur, GA, USA., Klarin D; Malcolm Randall VA Medical Center, Gainesville, FL, USA.; Division of Vascular Surgery and Endovascular Therapy, University of Florida College of Medicine, Gainesville, FL, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zhu X; VA Palo Alto Health Care System, Palo Alto, CA, USA.; Department of Statistics, The Pennsylvania State University, University Park, PA, USA.; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA.; Department of Statistics, Stanford University, Stanford, CA, USA., Thorleifsson G; deCODE genetics/Amgen, Reykjavik, Iceland., Helgadottir A; deCODE genetics/Amgen, Reykjavik, Iceland., Gudbjartsson DF; deCODE genetics/Amgen, Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Holm H; deCODE genetics/Amgen, Reykjavik, Iceland., Olafsson I; Department of Clinical Biochemistry, Landspitali-National University Hospital of Iceland, Reykjavik, Iceland., Akiyama M; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Sakaue S; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.; Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Terao C; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Kanai M; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Zhou W; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Brumpton BM; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Department of Thoracic Medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Rasheed H; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Ruotsalainen SE; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Havulinna AS; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Veturi Y; Department of Genetics, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Feng Q; Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Rosenthal EA; Department of Medicine (Medical Genetics), University of Washington, Seattle, WA, USA., Lingren T; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Pacheco JA; Center for Genetic Medicine, Northwestern University, Evanston, IL, USA., Pendergrass SA; Genentech, South San Francisco, CA, USA., Haessler J; Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Bradford Y; Department of Genetics, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Miller JE; Department of Genetics, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Usher Institute for Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UK., Lin K; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Millwood IY; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Hindy G; Department of Population Medicine, Qatar University College of Medicine, QU Health, Doha, Qatar., Rasheed A; Center for Non-Communicable Diseases, Karachi, Pakistan., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Turman C; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Huang H; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Graff M; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Brown MR; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Southall, UK.; Imperial College Healthcare NHS Trust, London, UK., Yu K; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Schmidt EM; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Pandit A; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Gustafsson S; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Yin X; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Zhao JH; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge Strangeways Research Laboratory, Cambridge, UK., Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Jang HM; Department of Precision Medicine, Division of Genome Science, National Institute of Health, Cheongju-si, South Korea., Yoon K; Department of Precision Medicine, Division of Genome Science, National Institute of Health, Cheongju-si, South Korea., Medina-Gomez C; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Pitsillides A; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Hottenga JJ; Department of Biological Psychology, Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health, VU Medical Center Amsterdam, Amsterdam, The Netherlands., Willemsen G; Department of Biological Psychology, Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, VU Medical Center Amsterdam, Amsterdam, The Netherlands., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Ji Y; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Gao Z; Department of Clinical Acupuncture and Moxibustion, Nanjing University of Chinese Medicine, Nanjing, China.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Haworth S; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Bristol Dental School, University of Bristol, Bristol, UK., Mitchell RE; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Chai JF; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Aadahl M; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, USA., Manichaikul A; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Warren HR; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, John Vane Science Centre, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Ramirez J; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, John Vane Science Centre, Queen Mary University of London, London, UK., Bork-Jensen J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kårhus LL; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Goel A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK., Sabater-Lleal M; Group of Genomics of Complex Diseases, Research Institute of Hospital de la Santa Creu i Sant Pau (IIB Sant Pau), Barcelona, Spain.; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Noordam R; Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands., Sidore C; Institute for Genetic and Biomedical Research, Italian National Council of Research (IRGB CNR), Cagliari,, Italy., Fiorillo E; Institute for Genetic and Biomedical Research, Italian National Council of Research (IRGB CNR), Lanusei, Italy., McDaid AF; University Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Marques-Vidal P; Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Wielscher M; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK., Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands., Sattar N; BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, UK., Møllehave LT; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Thuesen BH; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Munz M; Institute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research), Partner site Hamburg/Lübeck/Kiel, University Heart Center Lübeck, Lübeck, Germany.; Charité-University Medicine Berlin, Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Department of Periodontology and Synoptic Dentistry, Berlin Institute of Health, Institute for Dental and Craniofacial Sciences, Berlin, Germany., Zeng L; Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, Munich, Germany.; Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Partner site Munich Heart Alliance, Munich, Germany., Huang J; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Yang B; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Poveda A; Lund University Diabetes Centre, Malmo, Sweden., Kurbasic A; Lund University Diabetes Centre, Malmo, Sweden., Lamina C; Department of Genetics and Pharmacology, Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.; German Chronic Kidney Disease Study, Innsbruck, Austria., Forer L; Department of Genetics and Pharmacology, Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.; German Chronic Kidney Disease Study, Innsbruck, Austria., Scholz M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany., Galesloot TE; Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands., Bradfield JP; Quantinuum Research, Wayne, PA, USA., Daw EW; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, USA., Zmuda JM; Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA., Mitchell JS; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy., Fuchsberger C; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy., Christensen H; Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, USA., Wojczynski MK; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, USA., Preuss M; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK., Christofidou P; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Verweij N; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Benjamins JW; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Engmann J; Institute of Cardiovascular Sciences, University College London, London, UK.; Department of Epidemiology and Public Health, University College London, London, UK., Kember RL; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA., Slieker RC; Amsterdam UMC, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands., Lo KS; Montreal Heart Institute, Montreal, Quebec, Canada., Zilhao NR; Icelandic Heart Association, Reykjavik, Iceland., Le P; Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada., Kleber ME; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Synlab MVZ Humangenetik Mannheim, Mannheim, Germany., Delgado GE; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Huo S; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Ikeda DD; Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical, Tokushima, Japan., Iha H; Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical, Tokushima, Japan., Yang J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; Institute for Advanced Research, Wenzhou Medical University, Wenzhou, China., Liu J; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Leonard HL; Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, MD, USA.; Data Tecnica International, Glen Echo, MD, USA., Marten J; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Schmidt B; Institute for Medical Informatics, Biometrie and Epidemiology, University of Duisburg-Essen, Essen, Germany., Arendt M; Institute for Medical Informatics, Biometrie and Epidemiology, University of Duisburg-Essen, Essen, Germany.; Department of Computer Science, University of Applied Sciences and Arts Dortmund, Dortmund, Germany., Smyth LJ; Centre for Public Health, Queen's University of Belfast, Belfast, UK., Cañadas-Garre M; Centre for Public Health, Queen's University of Belfast, Belfast, UK., Wang C; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Nakatochi M; Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan., Wong A; MRC Unit for Lifelong Health and Ageing at UCL, London, UK., Hutri-Kähönen N; Department of Pediatrics, Tampere University Hospital, Tampere, Finland.; Department of Pediatrics, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Sim X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Xia R; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Huerta-Chagoya A; Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, UNAM, Ciudad de Mexico, Mexico, Mexico., Fernandez-Lopez JC; Departamento de Genómica Computacional, Instituto Nacional de Medicina Genómica, Ciudad de Mexico, Mexico, Mexico., Lyssenko V; Center for Diabetes Research, University of Bergen, Bergen, Norway.; Lund University Diabetes Center, Lund University, Malmo, Sweden., Ahmed M; Genomic Research on Complex Diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India., Jackson AU; Department of Biostatistics and Center for Statistics Genetics, University of Michigan, Ann Arbor, MI, USA., Yousri NA; Department of Genetic Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar.; Department of Computer and Systems Engineering, Alexandria University, Alexandria, Egypt., Irvin MR; Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Oldmeadow C; Hunter Medical Research Institute, Newcastle, New South Wales, Australia., Kim HN; Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.; Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, Korea., Ryu S; Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.; Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea., Timmers PRHJ; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK., Arbeeva L; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA., Dorajoo R; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Lange LA; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, Anschutz Medical Campus, University of Colorado, Denver, Aurora, CO, USA., Chai X; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Ophthalmology, National University of Singapore and National University Health System, Singapore, Singapore., Prasad G; Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.; Academy of Scientific and Innovative Research, CSIR-Institute of Genomics and Integrative Biology Campus, New Delhi, India., Lorés-Motta L; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands., Pauper M; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands., Long J; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA., Li X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, USA., Theusch E; Department of Pediatrics, University of California, San Francisco, Oakland, CA,, USA., Takeuchi F; National Center for Global Health and Medicine, Tokyo, Japan., Spracklen CN; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.; Department of Biostatistics and Epidemiology, University of Massachusetts-Amherst, Amherst, MA,, USA., Loukola A; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Bollepalli S; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Warner SC; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Wang YX; Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing, China.; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Wei WB; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Nutile T; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy., Ruggiero D; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy.; IRCCS Neuromed, Pozzilli, Isernia, Italy., Sung YJ; Department of Psychiatry, Washington University, St Louis, MO, USA., Hung YJ; Division of Endocrinology and Metabolism, Tri-Service General Hospital Songshan Branch, Taipei, Taiwan., Chen S; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Liu F; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Yang J; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Kentistou KA; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK., Gorski M; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany., Brumat M; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy., Meidtner K; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Smith JA; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Hebbar P; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait, Kuwait., Farmaki AE; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, Greece.; Department of Population Science and Experimental Medicine, University College London, London, UK., Hofer E; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Graz, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria., Lin M; Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC, USA., Xue C; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Zhang J; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Concas MP; Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy., Vaccargiu S; Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Sassari, Italy., van der Most PJ; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Pitkänen N; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland., Cade BE; Sleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA., Lee J; Sleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA., van der Laan SW; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Chitrala KN; Laboratory of Epidemiology and Population Science, National Institute on Aging Intramural Research Program, NIH Biomedical Research Center, NIA, Baltimore, MD, USA., Weiss S; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald and University Medicine Greifswald, Greifswald, Germany., Zimmermann ME; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Lee JY; Oneomics, Bucheon, Korea., Choi HS; Department of Biomedical Science, Hallym University, Chuncheon, Korea., Nethander M; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Freitag-Wolf S; Institute of Medical Informatics and Statistics, Kiel University, Kiel, Germany., Southam L; Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Wellcome Trust Sanger Institute, Hinxton, UK., Rayner NW; Wellcome Sanger Institute, Hinxton, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Oxford Centre for Diabetes Endocrinology and Metabolism, Oxford, UK., Wang CA; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia., Lin SY; Center for Geriatrics and Gerontology, Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan.; School of Medicine, National Defense Medical Center, Taipei, Taiwan., Wang JS; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan., Couture C; Department of Kinesiology, Université Laval, Quebec, Quebec, Canada., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Nikus K; Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland.; Department of Cardiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Cuellar-Partida G; University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia., Vestergaard H; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Medicine, Bornholms Hospital, Ronne, Denmark., Hildalgo B; School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Giannakopoulou O; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Cai Q; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA., Obura MO; Amsterdam UMC, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands., van Setten J; Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Li X; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Schwander K; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, USA., Terzikhan N; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Shin JH; Department of Biomedical Science, Hallym University, Chuncheon, Korea., Jackson RD; Division of Endocrinology, Ohio State University, Columbus, OH, USA., Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA, USA., Martin LW; School of Medicine and Health Sciences, George Washington University, Washington, DC, USA., Chen Z; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Li L; Department of Epidemiology, School of Public Health, Peking University Health Science Center, Beijing, China., Highland HM; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Young KL; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Kawaguchi T; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Thiery J; LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Institute for Laboratory Medicine, University Hospital Leipzig, Leipzig, Germany., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Nadkarni GN; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD, USA., Li H; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, MD, USA.; Data Tecnica International, Glen Echo, MD, USA., Raitakari OT; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland., Ichihara S; Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan., Wild SH; Centre for Population Health Sciences, Usher Institute, University of Edinburgh, Edinburgh, UK., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Campbell H; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK., Jäger S; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Nabika T; Department of Functional Pathology, Shimane University School of Medicine, Izumo, Japan., Al-Mulla F; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait, Kuwait., Niinikoski H; Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.; Department of Physiology, University of Turku, Turku, Finland., Braund PS; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Kolcic I; Faculty of Medicine, University of Split, Split, Croatia., Kovacs P; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Giardoglou T; Department of Nutrition-Dietetics, Harokopio University, Eleftheriou Venizelou, Athens, Greece., Katsuya T; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan., Bhatti KF; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., de Kleijn D; Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., de Borst GJ; Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Kim EK; Corneal Dystrophy Research Institute, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea., Adams HHH; Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Ikram MA; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Zhu X; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Asselbergs FW; Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Kraaijeveld AO; Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Beulens JWJ; Amsterdam UMC, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.; Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands., Shu XO; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA., Rallidis LS; Second Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Mitchell P; Center for Vision Research, Department of Ophthalmology and The Westmead Institute, University of Sydney, Sydney, New South Wales, Australia., Hewitt AW; Menzies Institute for Medical Research, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.; Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.; Department of Clinical Physiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Pérusse L; Department of Kinesiology, Université Laval, Quebec, Quebec, Canada.; Institute of Nutrition and Functional Foods (INAF), Université Laval, Quebec, Quebec, Canada., Bouchard C; Pennington Biomedical Research Center, Baton Rouge, LA, USA., Tönjes A; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, USA., Pennell CE; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia., Mori TA; Medical School, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Western Australia, Australia., Lieb W; Institute of Epidemiology, Kiel University, Kiel, Germany., Franke A; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany., Ohlsson C; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Drug Treatment, Sahlgrenska University Hospital, Gothenburg, Sweden., Mellström D; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Geriatric Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Cho YS; Department of Biomedical Science, Hallym University, Chuncheon, Korea., Lee H; Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea., Yuan JM; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Koh WP; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore, Singapore., Rhee SY; Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea., Woo JT; Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea., Heid IM; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Stark KJ; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Völzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Homuth G; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald and University Medicine Greifswald, Greifswald, Germany., Evans MK; Laboratory of Epidemiology and Population Science, National Institute on Aging Intramural Research Program, NIH Biomedical Research Center, Baltimore, MD, USA., Zonderman AB; Laboratory of Epidemiology and Population Science, National Institute on Aging Intramural Research Program, NIH Biomedical Research Center, Baltimore, MD, USA., Polasek O; Faculty of Medicine, University of Split, Split, Croatia., Pasterkamp G; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Hoefer IE; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Redline S; Sleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA., Pahkala K; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, Turku, Finland., Oldehinkel AJ; Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Snieder H; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Biino G; Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy., Schmidt R; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Graz, Austria., Schmidt H; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria., Chen YE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Bandinelli S; Local Health Unit Toscana Centro, Firenze, Italy., Dedoussis G; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, Greece., Thanaraj TA; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait, Kuwait., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kato N; National Center for Global Health and Medicine, Tokyo, Japan., Schulze MB; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany., Girotto G; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.; Institute for Maternal and Child Health IRCCS 'Burlo Garofolo', Trieste, Italy., Jung B; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany., Böger CA; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.; Department of Nephrology, Diabetology, Rheumatology, Traunstein Hospital, Traunstein, Germany.; KfH Kidney Center Traunstein, Traunstein, Germany., Joshi PK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., De Jager PL; Center for Translational and Systems Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Lu X; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Mamakou V; Medical School, National and Kapodistrian University Athens, Athens, Greece.; Dromokaiteio Psychiatric Hospital, Athens, Greece., Brown M; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK., Caulfield MJ; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, John Vane Science Centre, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Munroe PB; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, John Vane Science Centre, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, USA., Ciullo M; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy.; IRCCS Neuromed, Pozzilli, Isernia, Italy., Jonas JB; Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.; Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Kaprio J; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Pajukanta P; Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA, USA., Adair LS; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.; Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA., Bechayda SA; USC-Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines.; Department of Anthropology, Sociology, and History, University of San Carlos, Cebu City, Philippines., de Silva HJ; Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Wickremasinghe AR; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Krauss RM; Departments of Pediatrics and Medicine, University of California, San Francisco, San Francisco, CA, USA., Wu JY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Zheng W; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA., den Hollander AI; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands., Bharadwaj D; Academy of Scientific and Innovative Research, CSIR-Institute of Genomics and Integrative Biology Campus, New Delhi, India.; Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Heng CK; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore., Nelson AE; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA.; Department of Medicine, University of North Carolina, Chapel Hill, NC, USA., Golightly YM; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA.; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.; Injury Prevention Research Center, University of North Carolina, Chapel Hill, NC, USA.; Division of Physical Therapy, University of North Carolina, Chapel Hill, NC, USA., Wilson JF; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK., Penninx B; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, VU Medical Center Amsterdam, Amsterdam, The Netherlands., Kim HL; Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul, Korea., Attia J; Hunter Medical Research Institute, Newcastle, New South Wales, Australia.; Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia., Scott RJ; Hunter Medical Research Institute, Newcastle, New South Wales, Australia.; Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia., Rao DC; Division of Biostatistics, Washington University School of Medicine, St Louis, MO, USA., Arnett DK; University of Kentucky, College of Public Health, Lexington, KY, USA., Hunt SC; Department of Genetic Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar.; Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA., Walker M; Institute of Cellular Medicine (Diabetes), The Medical School, Newcastle University, Newcastle upon Tyne, UK., Koistinen HA; Department of Population Health, Finnish Institute for Health and Welfare, Helsinki, Finland.; University of Helsinki and Department of Medicine, Helsinki University Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland., Chandak GR; Genomic Research on Complex Diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India., Yajnik CS; Diabetology Research Centre, KEM Hospital and Research Centre, Pune, India., Mercader JM; Harvard Medical School, Boston, MA, USA.; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Tusié-Luna T; Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico.; Instituto de Investigaciones Biomédicas, UNAM, Ciudad de México, Mexico, Mexico.; Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Bimédicas UNAM/ Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico., Aguilar-Salinas CA; Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico.; Dirección de Nutrición and Unidad de Estudios de Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico., Villalpando CG; Instituto Nacional de Salud Publica y Centro de Estudios en Diabetes, Cuernavaca, Mexico., Orozco L; Instituto Nacional de Medicina Genómica, Mexico, Mexico., Fornage M; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Tai ES; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., van Dam RM; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Chaturvedi N; MRC Unit for Lifelong Health and Ageing at UCL, London, UK., Yokota M; Kurume University School of Medicine, Kurume, Japan., Liu J; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Reilly DF; Genetics, Merck Sharp & Dohme, Kenilworth, NJ, USA., McKnight AJ; Centre for Public Health, Queen's University of Belfast, Belfast, UK., Kee F; Centre for Public Health, Queen's University of Belfast, Belfast, UK., Jöckel KH; Institute for Medical Informatics, Biometrie and Epidemiology, University of Duisburg-Essen, Essen, Germany., McCarthy MI; Genentech, South San Francisco, CA, USA.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Palmer CNA; Population Health and Genomics, University of Dundee, Ninwells Hospital and Medical School, Dundee, UK., Vitart V; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Simonsick E; Intramural Research Program, National Institute on Aging, Baltimore, MD, USA., van Duijn CM; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Lu F; The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China., Qu J; The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China., Hishigaki H; Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical, Tokushima, Japan., Lin X; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., März W; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Synlab Academy, Synlab, Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria., Parra EJ; Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada., Cruz M; Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico, Mexico., Gudnason V; Icelandic Heart Association, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Tardif JC; Montreal Heart Institute, Montreal, Quebec, Canada.; Department of Medicine, Faculty of Medecine, Université de Montréal, Quebec, Quebec, Canada., Lettre G; Montreal Heart Institute, Montreal, Quebec, Canada.; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada., 't Hart LM; Amsterdam UMC, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Elders PJM; Amsterdam UMC, Department of General Practice and Elderly Care, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands., Damrauer SM; Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA., Kumari M; Institute of Social and Economic Research, University of Essex, Essex, UK., Kivimaki M; Department of Epidemiology and Public Health, University College London, London, UK., van der Harst P; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Province MA; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, USA., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanent Washington Health Research Institute, Seattle, WA, USA., Brandslund I; Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark.; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark., Pramstaller PP; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy., Christensen K; Danish Aging Research Center, University of Southern Denmark, Odense, Denmark., Ripatti S; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Widén E; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA., Grant SFA; 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University of Sassari, Sassari, Italy., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands., van Dijk KW; Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands., Watkins H; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK., Strachan DP; Population Health Research Institute, St George's University of London, London, UK., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Sever P; National Heart and Lung Institute, Imperial College London, London, UK., Poulter N; School of Public Health, Imperial College London, London, UK., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, USA., Dantoft TM; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Karpe F; OCDEM, University of Oxford, Churchill Hospital, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK., Neville MJ; OCDEM, University of Oxford, Churchill Hospital, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK., Timpson NJ; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Cheng CY; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; 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Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China., Kim YJ; Department of Precision Medicine, Division of Genome Science, National Institute of Health, Cheongju-si, South Korea., Tabara Y; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Zeggini E; Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Wellcome Trust Sanger Institute, Hinxton, UK.; TUM School of Medicine, Technical University of Munich (TUM) and Klinikum Rechts der Isar, Munich, Germany., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Laakso M; 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Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.; Department of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway., Åsvold BO; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.; Department of Endocrinology, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Kubo M; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Kamatani Y; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Okada Y; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.; Laboratory of Statistical Immunology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan., Murakami Y; Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Thorsteinsdottir U; deCODE genetics/Amgen, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Stefansson K; deCODE genetics/Amgen, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Ho YL; VA Boston Healthcare System, Boston, MA, USA., Lynch JA; VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, USA.; University of Massachusetts, Boston, MA, USA., Rader DJ; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Tsao PS; VA Palo Alto Health Care System, Palo Alto, CA, USA.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA., Chang KM; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael J. 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Publikováno v: Nature [Nature] 2021 Dec; Vol. 600 (7890), pp. 675-679. Date of Electronic Publication: 2021 Dec 09.