Protein Catalyzed Capture Agents with Tailored Performance for In Vitro and In Vivo Applications

Autor: Coppock, Matthew B., Warner, Candice R., Dorsey, Brandi, Orlicki, Joshua A., Sarkes, Deborah A., Lai, Bert T., Pitram, Suresh M., Rohde, Rosemary D., Malette, Jacquie, Wilson, Jeré A., Kearney, Paul, Fang, Kenneth C., Law, Scott M., Candelario, Sherri L., Farrow, Blake, Finch, Amethist S., Agnew, Heather D., Heath, James R., Stratis-Cullum, Dimitra N.

We report on peptide-based ligands matured through the protein catalyzed capture (PCC) agent method to tailor molecular binders for in vitro sensing/diagnostics and in vivo pharmacokinetics parameters. A vascular endothelial growth factor (VEGF) bind

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https://resolver.caltech.edu/CaltechAUTHORS:20160901-081827918

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Protein catalyzed capture agents with tailored performance for in vitro and in vivo applications.

Autor: Coppock MB; Sensors and Electron Devices Directorate, U.S. Army Research Laboratory, Adelphi, MD, 20783., Warner CR; Excet, Springfield, VA 22151 supporting USA Edgewood Chemical Biological Center, Aberdeen Proving Ground, MD, 21010., Dorsey B; Federal Staffing Resources, Annapolis, MD supporting U.S. Army Research Laboratory, Adelphi, MD, 20783., Orlicki JA; Weapons and Materials Research Directorate, U.S. Army Research Laboratory, Aberdeen Proving Ground, MD, 21005., Sarkes DA; Sensors and Electron Devices Directorate, U.S. Army Research Laboratory, Adelphi, MD, 20783., Lai BT; Indi Molecular, 6162 Bristol Parkway, Culver City, CA, 90230., Pitram SM; Indi Molecular, 6162 Bristol Parkway, Culver City, CA, 90230., Rohde RD; Indi Molecular, 6162 Bristol Parkway, Culver City, CA, 90230., Malette J; Indi Molecular, 6162 Bristol Parkway, Culver City, CA, 90230., Wilson JA; Indi Molecular, 6162 Bristol Parkway, Culver City, CA, 90230., Kearney P; Integrated Diagnostics, Seattle, WA, 98109., Fang KC; Integrated Diagnostics, Seattle, WA, 98109., Law SM; Integrated Diagnostics, Seattle, WA, 98109., Candelario SL; Integrated Diagnostics, Seattle, WA, 98109., Farrow B; Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA, 91125., Finch AS; Sensors and Electron Devices Directorate, U.S. Army Research Laboratory, Adelphi, MD, 20783., Agnew HD; Indi Molecular, 6162 Bristol Parkway, Culver City, CA, 90230., Heath JR; Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA, 91125., Stratis-Cullum DN; Sensors and Electron Devices Directorate, U.S. Army Research Laboratory, Adelphi, MD, 20783.

Publikováno v: Biopolymers [Biopolymers] 2017 Mar; Vol. 108 (2).