Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Warne, Robert L"'
Autor:
Koenig, Ronald J., Warne, Robert L., Brent, Gregory A., Harney, John W., Larsen, P. Reed, Moore, David D.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1988 Jul . 85(14), 5031-5035.
Externí odkaz:
https://www.jstor.org/stable/32352
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1987 Aug . 84(16), 5670-5674.
Externí odkaz:
https://www.jstor.org/stable/30101
Autor:
Warne Robert L, Heinz E. Moser, Keith Mansfield, Marianne Uteng, Tycho Heimbach, Wang Gang, Weidong Zhong, Lili Xie, Kathryn Rene Bracken, Margaret Weaver, Fumiaki Yokokawa, Zachary Kevin Sweeney, Satya Yendluri, Oliver L. Saunders, Kyoko Uehara, Siew Pheng Lim, Helen Gu, Alexandre Catoire, Martijn Fenaux, Julie Boisclair, Christopher T. Jones, Xiaodong Lin
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:7077-7085
Nucleoside or nucleotide inhibitors are a highly successful class of antivirals due to selectivity, potency, broad coverage, and high barrier to resistance. Nucleosides are the backbone of combination treatments for HIV, hepatitis B virus, and, since
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7db86318bf6c85669615e1feba92733
https://doi.org/10.1128/aac.01253-16
https://doi.org/10.1128/aac.01253-16
Autor:
Xiaolei Ma, Gladys T. Muiru, Vincent H. J. Leonard, Yongjin Xu, Dirksen E. Bussiere, Weidong Zhong, Charles Wartchow, David C. Tully, Warne Robert L, Steven Shia, Kyoko Uehara, Alexey Rivkin, Isabel Zaror, Lili Xie, Dianna M. Baldwin
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Scientific Reports
Scientific Reports
Influenza virus uses a unique mechanism to initiate viral transcription named cap-snatching. The PB2 subunit of the viral heterotrimeric RNA polymerase binds the cap structure of cellular pre-mRNA to promote its cleavage by the PA subunit. The result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676683a0bba30d0c344634542d5a6e86
https://doi.org/10.1038/s41598-017-09538-x
https://doi.org/10.1038/s41598-017-09538-x
Autor:
Johanna M. Jansen, Yipin Lu, Albert Lai, Isabel Zaror, Michael Doyle, Gwynn Pardee, Dirksen E. Bussiere, Sylvia Ma, Robert Elling, Kenneth Crawford, Janet Sim, Mulugeta Mamo, Yue Pan, Mark Knapp, Paul A. Barsanti, Kelly Yan, Elizabeth Ornelas, Warne Robert L, Li Zhang
Publikováno v:
Journal of molecular biology. 429(11)
ATR, a protein kinase in the PIKK family, plays a critical role in the cell DNA-damage response and is an attractive anticancer drug target. Several potent and selective inhibitors of ATR have been reported showing significant antitumor efficacy, wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5068d5a04ae8326ba31df3c5b2b21376
https://pubmed.ncbi.nlm.nih.gov/28433539
https://pubmed.ncbi.nlm.nih.gov/28433539
Autor:
Molly He, Timothy D. Machajewski, Daniel Menezes, Frazier Kelly, William R. Antonios-Mccrea, Jayesh Vora, Vincent P. Le, Warne Robert L, Gena Lapointe, Cynthia M. Shafer, Jazan Elisa, Sabina Pecchi, Paul Feucht, Helen Ye, Clarke Albany Taylor, Johanna M. Jansen, Mary Ellen Wernette-Hammond, Marion Wiesmann, Alex L. Harris, Carla Heise, Christopher McBride, Paul A. Renhowe, Kimberly Aardalen
Publikováno v:
Journal of Medicinal Chemistry. 52:278-292
The inhibition of key receptor tyrosine kinases (RTKs) that are implicated in tumor vasculature formation and maintenance, as well as tumor progression and metastasis, has been a major focus in oncology research over the last several years. Many pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa93393fd85e0f5070ceec19a9e2593
https://doi.org/10.1021/jm800790t
https://doi.org/10.1021/jm800790t
Autor:
Micah Steffek, James Sutton, Gladys T. Muiru, Steven Shia, Vincent H. J. Leonard, Xiaolei Ma, Kyoko Uehara, Lili Xie, Warne Robert L, Charles Wartchow, Dirksen E. Bussiere
Influenza virus polymerase catalyzes the transcription of viral mRNAs by a process known as "cap-snatching," where the 5'-cap of cellular pre-mRNA is recognized by the PB2 subunit and cleaved 10-13 nucleotides downstream of the cap by the endonucleas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e71aae3a67c969c079245e57b07e59
https://europepmc.org/articles/PMC4697171/
https://europepmc.org/articles/PMC4697171/
Autor:
Christine Fritsch, Cornelia Bellamacina, Yingyun Wang, Christine D. Wilson, Yumin Dai, John L. Langowski, Xiaohong Niu, Julie Chan, Marjorie Ison, Estelle Pfister, Jamie Narberes, Mika Lindvall, Christie Fanton, Gisele Nishiguchi, Tiffany Tsang, Warne Robert L, J. Alex Aycinena, Joseph Castillo, Pablo Garcia, Peter Drueckes, Stephen Basham, Wooseok Han, Richard Zang, Jianjun Yu, Paul Feucht, Min Chen, Matthew Burger, Joerg Trappe, Jing Lu, Audrey Kauffmann, Jiong Lan, Tatiana Zavorotinskaya, Michael Doyle, Jocelyn Holash
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 20(7)
Purpose: PIM kinases have been shown to act as oncogenes in mice, with each family member being able to drive progression of hematologic cancers. Consistent with this, we found that PIMs are highly expressed in human hematologic cancers and show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794cbe2432b36c7ce3bc09182e92487a
https://pubmed.ncbi.nlm.nih.gov/24474669
https://pubmed.ncbi.nlm.nih.gov/24474669
Autor:
Xueshi Hao, Linyi Wei, Xiang-ju Gu, Warne Robert L, Yi Liu, Dirksen E. Bussiere, Xiaoqi Gao, Tetsuo Uno
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(13)
A novel series of benzoazepin-2-ones were designed and synthesized targeting the PIF pocket of AGC protein kinases, among which a series of thioether-linked benzoazepin-2-ones were discovered to bind to the PIF pocket of 3-phosphoinositide-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa338e26bbb46c20220bb7e9054e4674
https://pubmed.ncbi.nlm.nih.gov/20627557
https://pubmed.ncbi.nlm.nih.gov/20627557
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