Increased expression of bronchial epithelial transient receptor potential vanilloid 1 channels in severe asthma

Autor: McGarvey, Lorcan P., Butler, Claire A., Stokesberry, Susan, Polley, Liam, McQuaid, Stephen, Abdullah, Hani'ah, Ashraf, Sadaf, McGahon, Mary K., Curtis, Tim M., Arron, Joe, Choy, David, Warke, Tim J., Bradding, Peter, Ennis, Madeleine, Zholos, Alexander, Costello, Richard W., Heaney, Liam G.

Publikováno v: McGarvey, L P, Butler, C A, Stokesberry, S, Polley, L, McQuaid, S, Abdullah, H, Ashraf, S, McGahon, M K, Curtis, T M, Arron, J, Choy, D, Warke, T J, Bradding, P, Ennis, M, Zholos, A, Costello, R W & Heaney, L G 2014, ' Increased expression of bronchial epithelial transient receptor potential vanilloid 1 channels in severe asthma ', Journal of Allergy and Clinical Immunology, vol. 133, no. 3, pp. 704-712 . https://doi.org/10.1016/j.jaci.2013.09.016

BACKGROUND: The airway epithelium is exposed to a range of physical and chemical irritants in the environment that are known to trigger asthma. Transient receptor potential (TRP) cation channels play a central role in sensory responses to noxious phy

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