The Hemogenic Competence of Endothelial Progenitors Is Restricted by Runx1 Silencing during Embryonic Development

Autor: Eliades, Alexia, Wareing, Sarah, Marinopoulou, Elli, Fadlullah Wilmot, Muhammad, Patel, Rahima, Grabarek, Joanna, Plusa, Berenika, Lacaud, Georges, Kouskoff, Valerie

Publikováno v: Cell Reports, Vol 15, Iss 10, Pp 2185-2199 (2016)
Cell Reports
Eliades, A, Wareing, S, Marinopoulou, E, Fadlullah Wilmot, M, Patel, R, Grabarek, J, Plusa, B, Lacaud, G & Kouskoff, V 2016, ' The hemogenic competence of endothelial progenitors is restricted by Runx1 silencing during embryonic development ', Cell Reports, vol. 15, no. 10, pp. 2185-2199 . https://doi.org/10.1016/j.celrep.2016.05.001

Summary It is now well-established that hematopoietic stem cells (HSCs) and progenitor cells originate from a specialized subset of endothelium, termed hemogenic endothelium (HE), via an endothelial-to-hematopoietic transition. However, the molecular

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