Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase

Autor: Jackman, A. L., Kimbell, R., Aherne, G. W., Brunton, L., Gerrit Jansen, Stephens, T. C., Smith, M. N., Wardleworth, J. M., Boyle, F. T.

Publikováno v: Clinical Cancer Research, 3(6), 911-21. American Association for Cancer Research Inc.
Jackman, A L, Kimbell, R, Aherne, G W, Brunton, L, Jansen, G, Stephens, T C, Smith, M N, Wardleworth, J M & Boyle, F T 1997, ' Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331 : a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase ', Clinical Cancer Research, vol. 3, no. 6, pp. 911-21 .
Scopus-Elsevier

ZD9331 is a drug that was developed from a potent class of water-soluble, C7-methyl-substituted, quinazoline-based inhibitors of thymidylate synthase (TS) that are transported into cells via a saturable, carrier-mediated system (reduced folate carrie

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https://research.vumc.nl/en/publications/f23dfad9-04ee-4f9e-8b7a-8ef5a45b2ba9

Quinazoline Antifolates Thymidylate Synthase Inhibitors:  Lipophilic Analogues with Modification to the C2-Methyl Substituent

Autor: Hennequin, L. F., Boyle, F. T., Wardleworth, J. M., Marsham, P. R., Kimbell, R., Jackman, A. L.

Publikováno v: Journal of Medicinal Chemistry; February 2, 1996, Vol. 39 Issue: 3 p695-704, 10p

ChemInform Abstract: The Preparation of α-Tetralones from Benzocyclobutenones via Sequential Thermal Electrocyclic Reactions.

Autor: HICKMAN, D. N., WALLACE, T. W., WARDLEWORTH, J. M.

Publikováno v: ChemInform; Dec1991, Vol. 22 Issue 51, pno-no, 1p

Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase.

Autor: Jackman AL; The Cancer Research Campaign Centre for Cancer Therapeutics at the Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG United Kingdom. annj@icr.ac.uk, Kimbell R, Aherne GW, Brunton L, Jansen G, Stephens TC, Smith MN, Wardleworth JM, Boyle FT

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 1997 Jun; Vol. 3 (6), pp. 911-21.

The antitumour activity of ZD9331, a non-polyglutamatable quinazoline thymidylate synthase inhibitor.

Autor: Jackman AL; CRC Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey, UK., Kimbell R, Brown M, Brunton L, Harrap KR, Wardleworth JM, Boyle FT

Publikováno v: Advances in experimental medicine and biology [Adv Exp Med Biol] 1994; Vol. 370, pp. 185-8.