Výsledky vyhledávání - "Ward M. Smith"

Mechanism and Implications of Brown Adipose Tissue Proliferation in Rats and Monkeys Treated with the Thiazolidinedione Darglitazone, a Potent Peroxisome Proliferator-Activated Receptor-γ Agonist

Autor: Gregg R. Lundeen, William M. Kluwe, Gerald L. Coleman, Ward M. Smith, Stanley W. Stadnicki, Michael D. Aleo, David K. Blackwell

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 305:1173-1182

Thiazolidinediones represent an established class of insulin sensitizing agents for treating noninsulin-dependent diabetes mellitus. Darglitazone, a thiazolidinedione approximately 200× more potent than ciglitazone, was evaluated in preclinical safe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e63f4d61389e346d2272a2f84e342a1
https://doi.org/10.1124/jpet.102.042648

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Percutaneous Absorption of Corticosteroids: Age, Site, and Skin-Sectioning Influences on Rates of Permeation of Hairless Mouse Skin by Hydrocortisone

Autor: Charangit R. Behl, Edwards E. Linn, Gordon L. Flynn, Ward M. Smith

Publikováno v: Journal of Pharmaceutical Sciences. 73:1287-1290

As part of a long-range plan to decipher the mechanism of mass transfer of corticosteroids across skin, the permeation of [3H]hydrocortisone through hairless mouse skin was characterized by in vitro diffusion cell techniques. Age and anatomical site-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd920256f00b5f2e97c202ce0317ba8
https://doi.org/10.1002/jps.2600730925

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Ether-water partitioning and permeability through nude mouse skin in vitro. II. Hydrocortisone 21-n-alkyl esters, alkanols and hydrophilic compounds

Autor: Chrisita Ackermann, Gordon L. Flynn, Ward M. Smith

Publikováno v: International Journal of Pharmaceutics. 36:67-71

Summary The permeability coefficients obtained by means of an infinite dose diffusion cell system with nude mouse skin in vitro were compared to the ether-water partition coefficients of the following compounds: glucose, urea, glycerol, thiourea, alk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec3960b660a13d30e0ff0f00cc3a3df6
https://doi.org/10.1016/0378-5173(87)90238-9

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