No evidence that circulating HIV-specific immune responses contribute to persistent inflammation and immune activation in persons on long-term ART.

Autor: Ward AR; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, New York.; Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University.; PhD Program in Epidemiology, Milken Institute School of Public Health, The George Washington University, Washington, DC., Thomas AS; Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts., Stevenson EM; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, New York., Huang SH; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, New York.; Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University., Keating SM; GigaGen, Inc., San Francisco.; Department of Laboratory Medicine, University of California San Francisco, San Francisco, California., Gandhi RT; Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts., McMahon DK; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Bosch RJ; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Macatangay BJ; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Cyktor JC; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Eron JJ; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Mellors JW; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Jones RB; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, New York.; Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University.

Publikováno v: AIDS (London, England) [AIDS] 2022 Oct 01; Vol. 36 (12), pp. 1617-1628. Date of Electronic Publication: 2022 Jun 22.

Aminobisphosphonates reactivate the latent reservoir in people living with HIV-1.

Autor: Sanz M; Department of Microbiology Immunology and Tropical Medicine, the George Washington University, Washington, DC, United States., Weideman AMK; Biostatistics Core, Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Ward AR; Department of Microbiology Immunology and Tropical Medicine, the George Washington University, Washington, DC, United States.; Department of Infectious Diseases, Weill Cornell Medicine, New York, NY, United States., Clohosey ML; UNC HIV Cure Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Garcia-Recio S; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Selitsky SR; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Mann BT; Department of Microbiology Immunology and Tropical Medicine, the George Washington University, Washington, DC, United States., Iannone MA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Whitworth CP; UNC HIV Cure Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Chitrakar A; Department of Microbiology Immunology and Tropical Medicine, the George Washington University, Washington, DC, United States., Garrido C; UNC HIV Cure Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Kirchherr J; UNC HIV Cure Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Coffey AR; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Tsai YH; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Samir S; Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Xu Y; Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Copertino D; Department of Infectious Diseases, Weill Cornell Medicine, New York, NY, United States., Bosque A; Department of Microbiology Immunology and Tropical Medicine, the George Washington University, Washington, DC, United States., Jones BR; Department of Microbiology Immunology and Tropical Medicine, the George Washington University, Washington, DC, United States.; Department of Infectious Diseases, Weill Cornell Medicine, New York, NY, United States., Parker JS; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Hudgens MG; Biostatistics Core, Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Goonetilleke N; Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Soriano-Sarabia N; Department of Microbiology Immunology and Tropical Medicine, the George Washington University, Washington, DC, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Sep 06; Vol. 14, pp. 1219250. Date of Electronic Publication: 2023 Sep 06 (Print Publication: 2023).

Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial.

Autor: Gunst JD; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Pahus MH; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Rosás-Umbert M; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Lu IN; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany., Benfield T; Department of Infectious Diseases, Copenhagen University Hospital-Amager and Hvidovre, Hvidovre, Denmark., Nielsen H; Department of Infectious Diseases, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Johansen IS; Department of Infectious Diseases, Odense University Hospital, University of Southern Denmark, Odense, Denmark., Mohey R; Department of Internal Medicine, Regional Hospital Herning, Herning, Denmark., Østergaard L; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Klastrup V; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Khan M; Department of Infectious Diseases, Imperial College Hospital, London, UK.; The National Institute for Health Research, Imperial Biomedical Research Centre, London, UK., Schleimann MH; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Olesen R; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Støvring H; Department of Public Health, Aarhus University, Aarhus, Denmark., Denton PW; Department of Biology, University of Nebraska at Omaha, Omaha, NE, USA., Kinloch NN; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada., Copertino DC; Infectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Ward AR; Infectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Alberto WDC; Infectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Nielsen SD; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Puertas MC; IrsiCaixa AIDS Research Institute, Badalona, Spain.; CIBERINFEC, Madrid, Spain., Ramos V; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA., Reeves JD; Labcorp-Monogram Biosciences, South San Francisco, CA, USA., Petropoulos CJ; Labcorp-Monogram Biosciences, South San Francisco, CA, USA., Martinez-Picado J; IrsiCaixa AIDS Research Institute, Badalona, Spain.; CIBERINFEC, Madrid, Spain.; University of Vic-Central University of Catalonia, Vic, Spain.; Catalan Institution for Research and Advanced Studies, Barcelona, Spain., Brumme ZL; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada., Jones RB; Infectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Fox J; Department of Genitourinary Medicine and Infectious Disease, Guy's and St Thomas' National Health Service Trust, London, UK.; Department of Genitourinary Medicine and Infectious Disease, The National Institute for Health Research Biomedical Research Centre, King's College London, London, UK., Tolstrup M; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Nussenzweig MC; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.; Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA., Caskey M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA., Fidler S; Department of Infectious Diseases, Imperial College Hospital, London, UK.; The National Institute for Health Research, Imperial Biomedical Research Centre, London, UK., Søgaard OS; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. olesoega@rm.dk.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark. olesoega@rm.dk.

Publikováno v: Nature medicine [Nat Med] 2022 Nov; Vol. 28 (11), pp. 2424-2435. Date of Electronic Publication: 2022 Oct 17.

SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8 ⁺ T-cells.

Autor: Stevenson EM; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Terry S; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Copertino D; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Leyre L; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Danesh A; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Weiler J; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Ward AR; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Khadka P; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., McNeil E; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Bernard K; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Miller IG; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Ellsworth GB; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Johnston CD; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Finkelsztein EJ; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Zumbo P; Applied Bioinformatics Core, Weill Cornell Medical College, New York, NY, USA., Betel D; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Applied Bioinformatics Core, Weill Cornell Medical College, New York, NY, USA., Dündar F; Applied Bioinformatics Core, Weill Cornell Medical College, New York, NY, USA.; Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY, USA., Duncan MC; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada., Lapointe HR; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada., Speckmaier S; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada., Moran-Garcia N; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada., Papa MP; Dept of Microbiology Immunology and Tropical Medicine, The George Washington University, Washington, DC, USA., Nicholes S; Dept of Microbiology Immunology and Tropical Medicine, The George Washington University, Washington, DC, USA., Stover CJ; Dept of Microbiology Immunology and Tropical Medicine, The George Washington University, Washington, DC, USA., Lynch RM; Dept of Microbiology Immunology and Tropical Medicine, The George Washington University, Washington, DC, USA., Caskey M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA., Gaebler C; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA., Chun TW; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID, NIH, Bethesda, MD, USA., Bosque A; Dept of Microbiology Immunology and Tropical Medicine, The George Washington University, Washington, DC, USA., Wilkin TJ; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Lee GQ; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Brumme ZL; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada., Jones RB; Department of Medicine, Weill Cornell Medical College, New York, NY, USA. rbjones@med.cornell.edu.; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA. rbjones@med.cornell.edu.

Publikováno v: Nature communications [Nat Commun] 2022 Aug 19; Vol. 13 (1), pp. 4888. Date of Electronic Publication: 2022 Aug 19.

Methylphenidate Improves Autonomic Functioning among Youth with Attention-Deficit/Hyperactivity Disorder.

Autor: Morris SSJ; Center for Children and Families, Department of Psychology, Florida International University, Miami, FL, USA. smorr064@fiu.ed., Musser ED; Center for Children and Families, Department of Psychology, Florida International University, Miami, FL, USA. emusser@fiu.edu., Tenenbaum RB; Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, TX , USA., Ward AR; Center for Children and Families, Department of Psychology, Florida International University, Miami, FL, USA., Raiker JS; Center for Children and Families, Department of Psychology, Florida International University, Miami, FL, USA., Coles EK; Center for Children and Families, Department of Psychology, Florida International University, Miami, FL, USA.

Publikováno v: Research on child and adolescent psychopathology [Res Child Adolesc Psychopathol] 2022 May; Vol. 50 (5), pp. 591-603. Date of Electronic Publication: 2021 Oct 06.