Výsledky vyhledávání - "Ward, Doelman"

Synthesis of glycopeptides and glycopeptide conjugates

Autor: Ward Doelman, Sander I. van Kasteren

Publikováno v: Organic and Biomolecular Chemistry

Protein glycosylation is a key post-translational modification important to many facets of biology. Glycosylation can have critical effects on protein conformation, uptake and intracellular routing. In immunology, glycosylation of antigens has been s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88934f930f6b45f85f46889ed7637d13
https://hdl.handle.net/1887/3453347

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Synthesis of Asparagine Derivatives Harboring a Lewis X Type DC‐SIGN Ligand and Evaluation of their Impact on Immunomodulation in Multiple Sclerosis

Autor: Can Araman, Mikkel H. S. Marqvorsen, Sander I. van Kasteren, Yvette van Kooyk, Ward Doelman, Fabrizio Chiodo, Sven C. M. Bruijns, Gijsbert A. van der Marel

Publikováno v: Chemistry-a European Journal
Chemistry-A European Journal, 27(8), 2742-2752. Wiley-VCH Verlag
Doelman, W, Marqvorsen, M H S, Chiodo, F, Bruijns, S C M, van der Marel, G A, van Kooyk, Y, van Kasteren, S I & Araman, C 2021, ' Synthesis of Asparagine Derivatives Harboring a Lewis X Type DC-SIGN Ligand and Evaluation of their Impact on Immunomodulation in Multiple Sclerosis ', Chemistry-A European Journal, vol. 27, no. 8, pp. 2742-2752 . https://doi.org/10.1002/chem.202004076, https://doi.org/10.1002/chem.202004076
Chemistry (Weinheim an Der Bergstrasse, Germany)

The protein myelin oligodendrocyte glycoprotein (MOG) is a key component of myelin and an autoantigen in the disease multiple sclerosis (MS). Post‐translational N‐glycosylation of Asn31 of MOG seems to play a key role in modulating the immune res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2984a3b3e6f76a64cafe3e324229db2
https://doi.org/10.1002/chem.202004076

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Single-molecule imaging of glycan–lectin interactions on cells with Glyco-PAINT

Autor: Tim P Hogervorst, Lorenzo Albertazzi, Ward Doelman, Jeroen D. C. Codée, Evangelia Bolli, Roger Riera, Silvia Pujals, Sander I. van Kasteren, Yan Ni

Publikováno v: Nature Chemical Biology
Nature Chemical Biology, 17, 1281-1288
Nature Chemical Biology, 17(12). Nature Publishing Group

Most lectins bind carbohydrate ligands with relatively low affinity, making the identification of optimal ligands challenging. Here we introduce a point accumulation in nanoscale topography (PAINT) super-resolution microscopy method to capture weak g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::434aa92617310cef23e0644df5167354

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Single-molecule imaging of glycan-lectin interactions on cells with Glyco-PAINT

Autor: Roger, Riera, Tim P, Hogervorst, Ward, Doelman, Yan, Ni, Silvia, Pujals, Evangelia, Bolli, Jeroen D C, Codée, Sander I, van Kasteren, Lorenzo, Albertazzi

Publikováno v: Nature chemical biology. 17(12)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b616a7ed44fea56e4e5887982dbb360d
https://pubmed.ncbi.nlm.nih.gov/34764473

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Amyloid-like Behavior of Site-Specifically Citrullinated Myelin Oligodendrocyte Protein (MOG) Peptide Fragments inside EBV-Infected B-Cells Influences Their Cytotoxicity and Autoimmunogenicity

Autor: Can Araman, Mikkel H. S. Marqvorsen, Nico J. Meeuwenoord, Bert A. 't Hart, Bart W. Faber, Sander I. van Kasteren, Ward Doelman, Miriam E. van Gent, Nicole Heijmans

Publikováno v: Biochemistry
Biochemistry, 58(6), 763-775

Multiple sclerosis (MS) is an autoimmune disorder manifested via chronic inflammation, demyelination, and neurodegeneration inside the central nervous system. The progressive phase of MS is characterized by neurodegeneration, but unlike classical neu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6d474d4952c2a39dc52836a8cc8516
http://europepmc.org/articles/PMC6374747

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Efficient synthesis and enzymatic extension of an N -GlcNAz asparagine building block

Autor: Ward Doelman, Mikkel H. S. Marqvorsen, Antony J. Fairbanks, Sivasinthujah Paramasivam, Sander I. van Kasteren

Publikováno v: Chemical Communications
Chemical Communications, 55(36), 5287-5290

N-Azidoacetyl-D-glucosamine (GlcNAz) is a particularly useful tool in chemical biology as the azide is a metabolically stable yet accessible handle within biological systems. Herein, we report a practical synthesis of FmocAsn(N-Ac3GlcNAz)OH, a buildi

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Fast and pH-Independent Elimination of trans-Cyclooctene by Using Aminoethyl-Functionalized Tetrazines

Autor: Jeroen D. C. Codée, Elmer Maurits, Sander I. van Kasteren, Alexi J. C. Sarris, Mark A. R. de Geus, Herman S. Overkleeft, Dmitri V. Filippov, Ward Doelman, Thomas Hansen

Publikováno v: Chemistry-A European Journal, 24(68), 18075-18081. Wiley-VCH Verlag
Chemistry-a European Journal
Chemistry-a European Journal, 24(68), 18075-18081
Sarris, A J C, Hansen, T, de Geus, M A R, Maurits, E, Doelman, W, Overkleeft, H S, Codée, J D C, Filippov, D V & van Kasteren, S I 2018, ' Fast and pH-Independent Elimination of trans-Cyclooctene by Using Aminoethyl-Functionalized Tetrazines ', Chemistry-A European Journal, vol. 24, no. 68, pp. 18075-18081 . https://doi.org/10.1002/chem.201803839
Chemistry – A European Journal

The inverse-electron-demand Diels–Alder/pyridazine elimination tandem reaction, in which the allylic substituent on trans-cyclooctene is eliminated following reaction with tetrazines, is gaining interest as a versatile bioorthogonal process. One po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097c25af79c23837417aa2e25f310cf9
https://research.vu.nl/en/publications/69aa5105-2889-4aeb-8c73-1a545c3fb6fd

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Structure-kinetic relationship studies of cannabinoid CB2 receptor agonists reveal substituent-specific lipophilic effects on residence time

Autor: Ward Doelman, Mark W. H. Hoorens, Marjolein Soethoudt, Mario van der Stelt, Andrea Martella, Laura H. Heitman

Publikováno v: Biochemical pharmacology, 152, 129-142
Biochemical pharmacology

R agonists can be designed to have optimal kinetic profiles, which could aid the lead optimization process in drug discovery for the study or treatment of inflammatory diseases.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d3c71c4a6e776a7385f7cc87f74d28
https://doi.org/10.1016/j.bcp.2018.03.018

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Structure-kinetic relationship studies of cannabinoid CB

Autor: Marjolein, Soethoudt, Mark W H, Hoorens, Ward, Doelman, Andrea, Martella, Mario, van der Stelt, Laura H, Heitman

Publikováno v: Biochemical pharmacology. 152

A decade ago, the drug-target residence time model has been (re-)introduced, which describes the importance of binding kinetics of ligands on their protein targets. Since then, it has been applied successfully for multiple protein targets, including

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::82ef35aca361870073686c90f65f795a
https://pubmed.ncbi.nlm.nih.gov/29574067

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