Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Wanwen Peng"'
NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation
Autor:
Meixiang Yang, Shasha Chen, Juan Du, Junming He, Yuande Wang, Zehua Li, Guangao Liu, Wanwen Peng, Xiaokang Zeng, Dan Li, Panglian Xu, Wei Guo, Zai Chang, Song Wang, Zhigang Tian, Zhongjun Dong
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
IL-15 orchestrates NK cell metabolism, proliferation, and activation. Here the authors show that Tsc1 is dispensable for mature NK cells but is critical for survival of immature NK by preventing their exhaustive proliferation and activation downstrea
Externí odkaz:
https://doaj.org/article/d609b2fc4fae4303b7be1b99f603f8c6
Autor:
Chenxu Cai, Zhongjun Dong, Meixiang Yang, Junming He, Wei Xiong, Wanwen Peng, Shasha Chen, Guangao Liu, Xiaokang Zeng
Publikováno v:
Cell Mol Immunol
Classical signaling lymphocyte activating molecule (SLAM) family receptors are abundant within many types of immune cells, whereas the nonclassical SLAM family receptors SLAMF8 and SLAMF9, which uniquely lack cytoplasmic signaling motifs, are highly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01bf96e3622d02094d25434d131fd57
https://doi.org/10.1038/s41423-018-0191-z
https://doi.org/10.1038/s41423-018-0191-z
NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation
Autor:
Zhongjun Dong, Shasha Chen, Wei Guo, Juan Du, Yuande Wang, Guangao Liu, Dan Li, Panglian Xu, Zhigang Tian, Zehua Li, Meixiang Yang, Xiaokang Zeng, Wanwen Peng, Junming He, Song Wang, Zai Chang
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Nature Communications
Nature Communications
Activation of metabolic signalling by IL-15 is required for natural killer (NK) cell development. Here we show that Tsc1, a repressor of mTOR, is dispensable for the terminal maturation, survival and function of NK cells but is critical to restrict e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d282762658b1a22f8fede46728141c
https://doi.org/10.1038/ncomms12730
https://doi.org/10.1038/ncomms12730