Improved Synthesis of 1-O-Acyl-β-d-Glucopyranose Tetraacetates

Autor: Yu Chen, Huan Lu, Yanyu Chen, Wansheng Yu, Hui Dai, Xianhua Pan

Publikováno v: Molecules, Vol 22, Iss 4, p 662 (2017)

An improved synthesis of 1-O-acyl glucosyl esters that avoids the use of expensive Ag reagents as well as the hydrolysis of unstable glucosyl bromides is reported. Notably, β-configuration products were obtained exclusively in good yields.

Externí odkaz: https://doaj.org/article/580bc94c667d41efb68900fc8ddc097e

A Facile, Six-Step Process for the Synthesis of (3S,5S)-3-Isopropyl-5-((2S,4S)-4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-2-oxopyrrolidine-1-carboxylic Acid tert-Butyl Ester, The Key Synthetic Intermediate of Aliskiren

Autor: Rui Huang, Feng Liu, Siyao Xu, Xianhua Pan, Wansheng Yu

Publikováno v: Organic Process Research & Development. 19:611-617

A facile, six-step process for the synthesis of (3S,5S)-3-isopropyl-5-((2S,4S)-4-isopropyl-5-oxotetrahydro- furan-2-yl)-2-oxopyrrolidine-1-carboxylic acid tert-butyl ester from (S)-4-benzyloxazolidin-2-one 2 in an overall 50% yield is reported. The k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f03cbccce790527d9cd3611cebdb9f3d
https://doi.org/10.1021/acs.oprd.5b00009

Improved Synthesis of 1-O-Acyl-β-d-Glucopyranose Tetraacetates

Autor: Chen Yanyu, Xianhua Pan, Wansheng Yu, Huan Lu, Hui Dai, Chen Yu

Publikováno v: Molecules; Volume 22; Issue 4; Pages: 662
Molecules, Vol 22, Iss 4, p 662 (2017)
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

An improved synthesis of 1-O-acyl glucosyl esters that avoids the use of expensive Ag reagents as well as the hydrolysis of unstable glucosyl bromides is reported. Notably, β-configuration products were obtained exclusively in good yields.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df751f0531a75d63710c2e15fce6d336

Synthesis of Sitagliptin Phosphate by a NaBH4/ZnCl2-catalyzed Diastereoselective Reduction

Autor: Lu Xu, Feng Liu, Wang Kun, Xianhua Pan, Wansheng Yu, Zhang Ruimin

Publikováno v: Chemistry Letters. 44:1170-1172

A practical asymmetric synthesis of sitagliptin phosphate, from 1-{3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo-[4,3-a]pyrazin-7(8H)-yl}-4-(2,4,5-trifluorophenyl)butane-1,3-dione, in overall 65....

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f45d13ea80852b9a95ec244b21f73c7a
https://doi.org/10.1246/cl.150390

Efficient synthesis of sitagliptin phosphate, a novel DPP-IV inhibitor, via a chiral aziridine intermediate

Autor: Xianhua Pan, Deng Fei, Wansheng Yu, Weijin Li, Qingling Lu, Qunhui Zhang, Li Xiaojun, Feng Liu

Publikováno v: Tetrahedron Letters. 54:6807-6809

Sitagliptin phosphate, a novel DPP-IV inhibitor of T2DM, has been synthesized via 12 linear steps, in an overall yield of 26%. The key step is the coupling reaction of 2,4,5-trifluorophenylmagnesium bromide with a chiral aziridine derivative, which w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c22a46389c8e8d75565a0e649622232e
https://doi.org/10.1016/j.tetlet.2013.09.136