Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Wanrui Zhang"'
Autor:
James T. Shoemaker, Wanrui Zhang, Selin I. Atlas, Richard A. Bryan, S. Walker Inman, Jelena Vukasinovic
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Remarkable advances in three-dimensional (3D) cell cultures and organ-on-a-chip technologies have opened the door to recapitulate complex aspects of human physiology, pathology, and drug responses in vitro. The challenges regarding oxygen delivery, t
Externí odkaz:
https://doaj.org/article/9056a615c4ca4da38ca6a102f3be0e15
Autor:
Selin I Atlas, S Walker Inman, Jelena Vukasinovic, Wanrui Zhang, Richard A Bryan, James T. Shoemaker
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences
Remarkable advances in three-dimensional (3D) cell cultures and organ-on-a-chip technologies have opened the door to recapitulate complex aspects of human physiology, pathology, and drug responses in vitro. The challenges regarding oxygen delivery, t
Autor:
Wanrui Zhang, Jean-Pierre Villeneuve, Maude Boisvert, Julie Bruneau, Elizabeth J. Elrod, Nicole F. Bernard, Arash Grakoui, Joseph Marcotrigiano, Naglaa H. Shoukry
Publikováno v:
The Journal of Immunology. 197:4848-4858
Acute hepatitis C virus (HCV) infection culminates in viral persistence in the majority of cases. Abs that recognize the envelope glycoproteins E1 and E2 are generated during the late stages of acute infection, yet their contribution to spontaneous v
Autor:
Guohua Gong, Heping Cheng, Robert T. Dirksen, Wanrui Zhang, Wang Wang, Xianhua Wang, Huaqiang Fang, Ming Zheng, Shey-Shing Sheu, Zhanglong Huang, Jiejia Xu
Publikováno v:
Free Radical Biology and Medicine. 51:1937-1940
Autor:
Xiuqin Zhang, Xing Zhang, Feng Gao, Shujiang Shang, Huaqiang Fang, Heping Cheng, Jianjie Ma, Shi-Qiang Wang, Jiejia Xu, Kunfu Ouyang, Yi Ding, Wanrui Zhang, Ju Chen, Ming Zheng, Xianhua Wang, Yao Xiao, Jing Chao Li, Xiao-Li Tian, Noah Weisleder, Wei Shang, Jingsong Zhou, Min Chen, Kaitao Li, Wang Wang
Publikováno v:
Cell Research. 21:1295-1304
The mitochondrion is essential for energy metabolism and production of reactive oxygen species (ROS). In intact cells, respiratory mitochondria exhibit spontaneous "superoxide flashes", the quantal ROS-producing events consequential to transient mito
Publikováno v:
Acta Pharmacologica Sinica. 27:821-826
Calcium [Ca2+] and reactive oxygen species (ROS) constitute the most important intracellular signaling molecules participating in the regulation and integration of diverse cellular functions. Here we briefly review cross-talk between the two prominen
Autor:
Wanrui Zhang, Xianhua Wang, Ming Zheng, Jue Zhang, Xiaohu Huang, Shuangxi Ji, Yanru Wang, Jiejia Xu, Clara Franzini-Armstrong, Ting Zhao, Lei Sun, Heping Cheng
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 110(8)
Mitochondria in many types of cells are dynamically interconnected through constant fusion and fission, allowing for exchange of mitochondrial contents and repair of damaged mitochondria. However, constrained by the myofibril lattice, the ∼6,000 mi
Autor:
Meng Ouyang, Ming Zheng, Wei Shang, Zhen Yang, Yi Ding, Chongshu Jian, Zhanglong Huang, Yuefan Wang, Xing Zhang, Jiejia Xu, Heping Cheng, Wanrui Zhang, Xianhua Wang, Tingting Hou
Publikováno v:
Journal of molecular and cellular cardiology. 52(5)
The role of mitochondrial reactive oxygen species (mitoROS) in cellular function remains obscure. By synthesizing recent data, we propose here that local dynamic mitoROS in the form of "superoxide flashes" serve as "signaling ROS" rather than "homeos
Autor:
Kunfu Ouyang, Robert T. Dirksen, Wang Wang, Kaitao Li, Ju Chen, Edward G. Lakatta, Linda Groom, Joseph P. Y. Kao, Mark P. Mattson, Heping Cheng, Huaqiang Fang, Weidong Wang, Shey-Shing Sheu, Aiwu Cheng, Ming Zheng, Jie Liu, Wanrui Zhang, Xianhua Wang, Peidong Han, Jinhu Yin
Publikováno v:
Cell. 134(2)
SummaryIn quiescent cells, mitochondria are the primary source of reactive oxygen species (ROS), which are generated by leakiness of the electron transport chain (ETC). High levels of ROS can trigger cell death, whereas lower levels drive diverse and
Autor:
Chunlei Chen, Ming Zheng, Rui-Ping Xiao, Kuang-Hueih Chen, Jian Tang, Tao Shen, Heping Cheng, Wanrui Zhang, Chun-Mei Cao
Publikováno v:
The Journal of biological chemistry. 282(32)
An inexorable loss of terminally differentiated heart muscle cells is a crucial causal factor for heart failure. Here, we have provided several lines of evidence to demonstrate that mitofusin-2 (Mfn-2; also called hyperplasia suppressor gene), a memb