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The potent and lung-selective inhaled pan JAK inhibitor TD-8236 limits airway inflammation without affecting systemic immunity in mice

Autor: Ashleigh Heinichen, Alexander McNamara, Elad Kaufman, Melanie A. Kleinschek, Eva Situ, Paul Fatheree, Wanju Lee, Christina G. Campbell

Publikováno v: Airway pharmacology and treatment.

Janus kinase (JAK) inhibitors target a family of kinases that transduce cytokine mediated signals via the JAK / Signal Transducer and Activator of Transcription (STAT) pathway. JAK/STAT signaling cytokines contribute to asthma airway inflammation. TD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59620c58a42ffd0f448ed35ee9b599f7
https://doi.org/10.1183/13993003.congress-2019.oa4952

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TD-8236, a lung-selective inhaled pan-JAK inhibitor, inhibits gene expression related to severe asthma and exhaled nitric oxide (FeNO), in 3-D airway epithelium liquid interface (ALI) cultures derived from asthmatic donors

Autor: Thomas Southworth, Nathan Pfeiffer, Glenn Crater, Elad Kaufman, Edmund J. Moran, Melanie A. Kleinschek, Emma Gordon, Thomas Scott, Dave Singh, Wanju Lee, Reuben Sana, Jacky Woo

Publikováno v: Journal of Allergy and Clinical Immunology. 145:AB116

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af15aa2b25bfef11c649e697f5544bce
https://doi.org/10.1016/j.jaci.2019.12.570

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Caffeoylglycolic acid methyl ester, a major constituent of sorghum, exhibits anti-inflammatory activity via the Nrf2/heme oxygenase-1 pathway

Autor: Wanju Lee, Young-Yeon Choo, Suhyun Lee, Phi Hung Nguyen, Byung Sun Min, Mi-Hee Woo, Jeong-Hyung Lee

Publikováno v: RSC Advances. 5:17786-17796

Sorghum contains diverse pharmacologically active phytochemicals including tannins, phenolic acids and anthocyanins. In the present study, we show that caffeoylglycolic acid methyl ester (CGME), a major constituent of the grains of Sorghum bicolor, e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::037396027061ccac01d56a0b87fdc817
https://doi.org/10.1039/c4ra13847c

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Mitochondrial Permeability Transition Pore in Inflammatory Apoptosis of Human Conjunctival Epithelial Cells and T Cells: Effect of Cyclosporin A

Autor: Larry A. Wheeler, Wanju Lee, Virginia L. Calder, Reuben Sana, Margarita Calonge, Michael E. Stern, Jianping Gao

Publikováno v: Investigative Opthalmology & Visual Science. 54:4717

Purpose To investigate the role of mitochondrial permeability transition pore (MPTP) and effect of cyclosporin A (CsA) on inflammatory apoptosis of human conjunctival epithelial cells (IOBA-NHC) and T cells. Methods IOBA-NHC and Jurkat cells were sti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0458b8b67d8039c4ca350028f134db1
https://doi.org/10.1167/iovs.13-11681

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