Zobrazeno 1 - 10 of 27 pro vyhledávání: '"Wanja M. Bernhardt"'
2
Data from Mutual Regulation of Hypoxia-Inducible Factor and Mammalian Target of Rapamycin as a Function of Oxygen Availability
Autor: Michael S. Wiesener, Kai-Uwe Eckardt, Christina Warnecke, Jan Steffen Juergensen, Alexander Weidemann, Wanja M. Bernhardt, Regina Schmidt, Katrin Jozefowski, Karl X. Knaup
The mammalian target of rapamycin (mTOR) regulates cellular growth and proliferation, mainly by controlling cellular translation. Most tumors show constitutive activation of the mTOR pathway. In hypoxia, mTOR is inactivated, which is believed to be p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79136757675fd2feee3a76bf5a5d589f
https://doi.org/10.1158/1541-7786.c.6542193.v1
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3
Reduction of obliterative bronchiolitis (OB) by prolyl-hydroxylase-inhibitors activating hypoxia-inducible transcription factors in an experimental mouse model
Autor: Christian Heim, Kai-Uwe Eckardt, Stephan M. Ensminger, B. Motsch, Michael Weyand, Martina Ramsperger-Gleixner, Wanja M. Bernhardt, S. Jalilova, Nicolai Burzlaff
Publikováno v: Transplant Immunology. 39:66-73
Background Obliterative bronchiolitis (OB) is the major limiting factor for long-term survival after lung transplantation. As previously shown, donor treatment with a PHD-inhibitor activating hypoxia-inducible transcription factors (HIFs) prevents gr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500c6b05d9a03513da436c0f4541f232
https://doi.org/10.1016/j.trim.2016.08.007
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4
Real-world study: Escalating targeted lipid-lowering treatment with PCSK9-inhibitors and lipoprotein apheresis
Autor: Franz Heigl, Markus Ketteler, Andrea Raabe, Reinhard Klingel, Michael Moesenthin, Volker Schettler, Wanja M. Bernhardt, Ulrich Julius, Ralf Kühn, Markus Knittel, Andreas Heibges, Josef Leebmann, Tilmann Röseler, Ralf Spitthöver, Eberhard Röseler, Carsten Schürfeld
Publikováno v: Journal of clinical apheresis. 34(4)
INTRODUCTION Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition with monoclonal antibodies has complemented the armamentarium of lipid-lowering therapy (LLT) before the final step of commencing chronic lipoprotein apheresis (LA). Data a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d30ae01cf99fe1a3a7e0312407a100a0
https://pubmed.ncbi.nlm.nih.gov/30817043
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5
Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD
Autor: Kai-Uwe Eckardt, Roland E. Schmieder, Paul Scigalla, Michael S. Wiesener, James J. Chou, Volkmar Günzler, Wanja M. Bernhardt
Publikováno v: Journal of the American Society of Nephrology. 21:2151-2156
The reasons for inadequate production of erythropoietin (EPO) in patients with ESRD are poorly understood. A better understanding of EPO regulation, namely oxygen-dependent hydroxylation of the hypoxia-inducible transcription factor (HIF), may enable
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943469e43755e055105dc2343324f2f9
https://doi.org/10.1681/asn.2010010116
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6
Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model
Autor: Johannes Schödel, M. Arend, S. Klaus, B. Yard, Carsten Willam, A. Reisenbuechler, U. Gottmann, Christina Warnecke, Wanja M. Bernhardt, Valentina Campean, F. Doyon, Michael S. Wiesener, Björn Buchholz, L. Flippin, Kai-Uwe Eckardt
Publikováno v: Proceedings of the National Academy of Sciences. 106:21276-21281
Long-term survival of renal allografts depends on the chronic immune response and is probably influenced by the initial injury caused by ischemia and reperfusion. Hypoxia-inducible transcription factors (HIFs) are essential for adaptation to low oxyg
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0aa3fbeaee5c799ef765bff79708e5
https://doi.org/10.1073/pnas.0903978106
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7
Mutual Regulation of Hypoxia-Inducible Factor and Mammalian Target of Rapamycin as a Function of Oxygen Availability
Autor: Christina Warnecke, Jan Steffen Juergensen, Wanja M. Bernhardt, Regina Schmidt, Katrin Jozefowski, Kai-Uwe Eckardt, Alexander Weidemann, Michael S. Wiesener, Karl X. Knaup
Publikováno v: Molecular Cancer Research. 7:88-98
The mammalian target of rapamycin (mTOR) regulates cellular growth and proliferation, mainly by controlling cellular translation. Most tumors show constitutive activation of the mTOR pathway. In hypoxia, mTOR is inactivated, which is believed to be p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57dcdecb1e99304292a0c9690fdcee70
https://doi.org/10.1158/1541-7786.mcr-08-0288
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8
Physiological basis for the use of erythropoietin in critically ill patients at risk for acute kidney injury
Autor: Kai-Uwe Eckardt, Wanja M. Bernhardt
Publikováno v: Current Opinion in Critical Care. 14:621-626
PURPOSE OF REVIEW Acute kidney injury (AKI) frequently occurs in critically ill patients and is an independent risk factor for poor outcome. The prevention of kidney injury in intensive care remains a great challenge as specific nephroprotective ther
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c129e4a972eb7cb6f019fdee664fe67
https://doi.org/10.1097/mcc.0b013e328317ee82
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9
Preconditional Activation of Hypoxia-Inducible Factors Ameliorates Ischemic Acute Renal Failure
Autor: Volkmar Günzler, Kai-Uwe Eckardt, Alexander Weidemann, Kerstin Amann, Michael S. Wiesener, Sarah Kany, Michael P. Arend, Valentina Câmpean, Christina Warnecke, Wanja M. Bernhardt, Carsten Willam, Jan-Steffen Jürgensen, Klaus Stephen J
Publikováno v: Journal of the American Society of Nephrology. 17:1970-1978
Activation of hypoxia-inducible transcription factor (HIF) has been identified as an important mechanism of cellular adaptation to low oxygen. Normoxic degradation of HIF is mediated by oxygen-dependent hydroxylation of specific prolyl residues of th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6cbb8937a4ab19382e6bd161cc81e46
https://doi.org/10.1681/asn.2005121302
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10
Stabilization of hypoxia inducible factor rather than modulation of collagen metabolism improves cardiac function after acute myocardial infarction in rats
Autor: Wanja M. Bernhardt, Astrid Schiche, Sebastian Philipp, Rainer Dietz, Kai-Uwe Eckardt, Bernhard Pilz, Jens Fielitz, Vera Regitz-Zagrosek, Roland Willenbrock, Alexander Weidemann, Jan Steffen Jürgensen
Publikováno v: European Journal of Heart Failure. 8:347-354
Prolyl hydroxylase domain-containing enzymes (PHD) hydroxylate a proline residue that controls the degradation of hypoxia induciblefactor (HIF). Hypoxia inhibits this hydroxylation thus increasing HIF levels. HIF is upregulated in ischemic tissues, g
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f7f9011e547b88bd450e1a7b0ed71b
https://doi.org/10.1016/j.ejheart.2005.10.009
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