Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Wanhai Qin"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/2fa6ae1f83fd40449c1910c3fe811b94
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and severe disease characterized by excessive matrix deposition in the lungs. Macrophages play crucial roles in maintaining lung homeostasis but are also central in the
Externí odkaz:
https://doaj.org/article/c5b7c0e436bb4f81b2d2c86b9d92d80e
Autor:
Xanthe Brands, Bastiaan W. Haak, Augustijn M. Klarenbeek, Joe Butler, Fabrice Uhel, Wanhai Qin, Natasja A. Otto, Marja E. Jakobs, Daniël R. Faber, René Lutter, W. Joost Wiersinga, Tom van der Poll, Brendon P. Scicluna
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-17 (2021)
Abstract Background The plasticity of monocytes enables them to exert multiple roles during an immune response, including promoting immune tolerance. How monocytes alter their functions to convey immune tolerance in the context of lower respiratory t
Externí odkaz:
https://doaj.org/article/b06b9c428497488dbd62d7b688aaab55
Publikováno v:
Bio-Protocol, Vol 12, Iss 1 (2022)
Experimental pneumonia models are important tools to study the pathophysiology of lung inflammation caused by microbial infections and the efficacy of (novel) drugs. We have applied a murine model of pneumonia induced by Pseudomonas (P.) aeruginosa i
Externí odkaz:
https://doaj.org/article/2cfcec470fa644ea8f3a615f275ae9af
Autor:
Hisatake Matsumoto, Brendon P. Scicluna, Kin Ki Jim, Fahimeh Falahi, Wanhai Qin, Berke Gürkan, Erik Malmström, Mariska T. Meijer, Joe M. Butler, Hina N. Khan, Tsuyoshi Takagi, Shunsuke Ishii, Marcus J. Schultz, Diederik van de Beek, Alex F. de Vos, Cornelis van ‘t Veer, Tom van der Poll
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Our previous work identified human immunodeficiency virus type I enhancer binding protein 1 (HIVEP1) as a putative driver of LPS-induced NF-κB signaling in humans in vivo. While HIVEP1 is known to interact with NF-ĸB binding DNA motifs, its functio
Externí odkaz:
https://doaj.org/article/9fdd81d996c34400a7bfadd47712bee9
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Host cells undergo complex transcriptional reprogramming upon infection. Epigenetic changes play a key role in the immune response to bacteria, among which DNA modifications that include methylation have received much attention in recent years. The e
Externí odkaz:
https://doaj.org/article/945a2350d13046a4bd41e9ad75af5bdd
Publikováno v:
Journal of Microbiology, Immunology and Infection, Vol 52, Iss 4, Pp 516-525 (2019)
Streptococcus suis (S. suis) type 2 (SS2) is an important zoonotic pathogen that causes swine streptococcosis, a widespread infectious disease that occurs in pig production areas worldwide and causes serious economic losses in the pork industry. Host
Externí odkaz:
https://doaj.org/article/c9d72e311d5b45d3ac4c585f24265a87
Autor:
Wanhai Qin, Xanthe Brands, Cornelis Van't Veer, Alex F de Vos, Jean-Claude Sirard, Joris J T H Roelofs, Brendon P Scicluna, Tom van der Poll
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009491 (2021)
DNA methyltransferase (Dnmt)3b mediates de novo DNA methylation and modulation of Dnmt3b in respiratory epithelial cells has been shown to affect the expression of multiple genes. Respiratory epithelial cells provide a first line of defense against p
Externí odkaz:
https://doaj.org/article/8c3b39229ccc45caa089e49ea838b990
Autor:
Wanhai Qin, Xanthe Brands, Cornelis van’t Veer, Alex F. de Vos, Brendon P. Scicluna, Tom van der Poll
Publikováno v:
Cells, Vol 11, Iss 5, p 787 (2022)
DNA methyltransferase 3b (Dnmt3b) has been suggested to play a role in the host immune response during bacterial infection. Neutrophils and other myeloid cells are crucial for lung defense against Pseudomonas (P.) aeruginosa infection. This study aim
Externí odkaz:
https://doaj.org/article/cd265f9c5dcf4f63864ac2afbf7a806f
Autor:
Wanhai Qin, Xanthe Brands, Hisatake Matsumoto, Joe M. Butler, Cornelis van’t Veer, Alex F. de Vos, Joris J. T. H. Roelofs, Brendon P. Scicluna, Tom van der Poll
Publikováno v:
Cells, Vol 11, Iss 1, p 82 (2021)
Tet methylcytosine dioxygenase 2 (Tet2) mediates demethylation of DNA. We here sought to determine the expression and function of Tet2 in macrophages upon exposure to lipopolysaccharide (LPS), and in the host response to LPS induced lung and peritone
Externí odkaz:
https://doaj.org/article/c463a230e7bd496991954bec4ac5fac2