Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Wangzhen, Shen"'
Autor:
Sarah Poliquin, Gerald Nwosu, Karishma Randhave, Wangzhen Shen, Carson Flamm, Jing-Qiong Kang
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4601 (2024)
A significant number of patients with genetic epilepsy do not obtain seizure freedom, despite developments in new antiseizure drugs, suggesting a need for novel therapeutic approaches. Many genetic epilepsies are associated with misfolded mutant prot
Externí odkaz:
https://doaj.org/article/6d044f4c6bf947ebaf7f7e008e1296f4
Publikováno v:
Biomolecules, Vol 13, Iss 12, p 1790 (2023)
Variants in the GABRB gene, which encodes the β subunit of the GABAA receptor, have been implicated in various epileptic encephalopathies and related neurodevelopmental disorders such as Dravet syndrome and Angelman syndrome. These conditions are of
Externí odkaz:
https://doaj.org/article/9a0837e3da4f4e31a92284985a43ac8f
Autor:
Felicia Mermer, Sarah Poliquin, Shuizhen Zhou, Xiaodong Wang, Yifeng Ding, Fei Yin, Wangzhen Shen, Juexin Wang, Kathryn Rigsby, Dong Xu, Taralynn Mack, Gerald Nwosu, Carson Flamm, Matthew Stein, Jing-Qiong Kang
Publikováno v:
Neurobiology of Disease, Vol 172, Iss , Pp 105810- (2022)
Objective: Mutations in γ-aminobutyric acid (GABA) transporter 1 (GAT-1)-encoding SLC6A1 have been associated with myoclonic atonic epilepsy and other phenotypes. We determined the patho-mechanisms of the mutant GAT-1, in order to identify treatment
Externí odkaz:
https://doaj.org/article/d1f63b8a4f894bc59d7315bb22010afa
Publikováno v:
Integrative Cancer Therapies, Vol 21 (2022)
Background: Previous studies have shown that berberine can inhibit glioma progression, although the underlying molecular mechanisms needed to be explored further. The aim of this study was to evaluate the suppressive effects of berberine on human gli
Externí odkaz:
https://doaj.org/article/909643c456fa4634ab786b6cd1931e06
Autor:
Souhrid Mukherjee, Thomas A. Cassini, Ningning Hu, Tao Yang, Bian Li, Wangzhen Shen, Christopher W. Moth, David C. Rinker, Jonathan H. Sheehan, Joy D. Cogan, John H. Newman, Rizwan Hamid, Robert L. Macdonald, Dan M. Roden, Jens Meiler, Georg Kuenze, John A. Phillips, John A. Capra
Publikováno v:
HGG Advances, Vol 3, Iss 4, Pp 100131- (2022)
Summary: Whole-exome sequencing (WES) in the clinic has identified several rare monogenic developmental and epileptic encephalopathies (DEE) caused by ion channel variants. However, WES often fails to provide actionable insight for rare diseases, suc
Externí odkaz:
https://doaj.org/article/80f15d97adae43d6b743ecd6b1a9570f
Autor:
Gerald Ikemefuna Nwosu, Wangzhen Shen, Kirill Zavalin, Sarah Poliquin, Karishma Randhave, Carson Flamm, Marshall Biven, Katherine Langer, Jing-Qiong Kang
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8458 (2023)
Lennox–Gastaut Syndrome (LGS) is a developmental and epileptic encephalopathy (DEE) characterized by multiple seizure types, electroencephalogram (EEG) patterns, and cognitive decline. Its etiology has a prominent genetic component, including varia
Externí odkaz:
https://doaj.org/article/2e63c53717424f5297f6b37bfe03cfc2
Autor:
Ciria C. Hernandez, Yanwen Shen, Ningning Hu, Wangzhen Shen, Vinodh Narayanan, Keri Ramsey, Wen He, Liping Zou, Robert L. Macdonald
Publikováno v:
Biomolecules, Vol 13, Iss 3, p 414 (2023)
Febrile seizures (FS) are the most common form of epilepsy in children between six months and five years of age. FS is a self-limited type of fever-related seizure. However, complicated prolonged FS can lead to complex partial epilepsy. We found that
Externí odkaz:
https://doaj.org/article/271466ba61d9486ca7466edf78a88a4b
Autor:
Jie Wang, Sarah Poliquin, Felicia Mermer, Jaclyn Eissman, Eric Delpire, Juexin Wang, Wangzhen Shen, Kefu Cai, Bing-Mei Li, Zong-Yan Li, Dong Xu, Gerald Nwosu, Carson Flamm, Wei-Ping Liao, Yi-Wu Shi, Jing-Qiong Kang
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-15 (2020)
Abstract Mutations in SLC6A1, encoding γ-aminobutyric acid (GABA) transporter 1 (GAT-1), have been recently associated with a spectrum of epilepsy syndromes, intellectual disability and autism in clinic. However, the pathophysiology of the gene muta
Externí odkaz:
https://doaj.org/article/cbe6c3611641421f8f2d03e15a5876da
Autor:
Shimian Qu, Chengwen Zhou, Rachel Howe, Wangzhen Shen, Xuan Huang, Mackenzie Catron, Ningning Hu, Robert L. Macdonald
Publikováno v:
Neurobiology of Disease, Vol 152, Iss , Pp 105296- (2021)
Externí odkaz:
https://doaj.org/article/2fa6179ab74a4364a0742dd877e8a641
Autor:
Shimian Qu, Laurel G. Jackson, Chengwen Zhou, DingDing Shen, Wangzhen Shen, Gerald Nwosu, Rachel Howe, Mackenzie A. Catron, Carson Flamm, Marshall Biven, Jing‐Qiong Kang, Robert L. Macdonald
Publikováno v:
Epilepsia. 64:1061-1073