Výsledky vyhledávání - "Wangsun Choi"

The scaffolding protein ZO-1 coordinates actomyosin and epithelial apical specializations in vitro and in vivo

Autor: Anne Sailer, Matthew A. Odenwald, Wangsun Choi, Wei-Ting Kuo, Alan S. Fanning, Jerrold R. Turner, Le Shen, Gurminder Singh, Yitang Wang

Publikováno v: Journal of Biological Chemistry. 293:17317-17335

Polarized epithelia assemble into sheets that compartmentalize organs and generate tissue barriers by integrating apical surfaces into a single, unified structure. This tissue organization is shared across organs, species, and developmental stages. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ceb4d9a11f09ce7408c08b69efc3370e
https://doi.org/10.1074/jbc.ra118.003908

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Scribble and Discs-large direct initial assembly and positioning of adherens junctions during the establishment of apical-basal polarity

Autor: Mark Peifer, Wangsun Choi, Teresa T. Bonello

Publikováno v: Development

Apical-basal polarity is a fundamental property of animal tissues. Drosophila embryos provide an outstanding model for defining mechanisms initiating and maintaining polarity. Polarity is initiated during cellularization, when cell-cell adherens junc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d4e91036491d6cded86921e4bbdfab
https://europepmc.org/articles/PMC6899021/

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TNF Activates FK506 Binding Protein 8 (FKBP8) Interactions That Direct Myosin Light Chain Kinase 1 (MLCK1) Recruitment to the Perijunctional Actomyosin Ring and Drive Epithelial Barrier Loss

Autor: Li Zuo, Wangsun Choi, Jerrold R. Turner, W. Vallen Graham

Publikováno v: The FASEB Journal. 33

Background Intestinal barrier dysfunction is thought to contribute to progression of inflammatory bowel disease and systemic disorders. We recently reported that a specific myosin light chain kinase splice variant, MLCK1, is recruited to the apical p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b46319e6609400f09275d7bc34fbf7d4
https://doi.org/10.1096/fasebj.2019.33.1_supplement.710.2

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Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability

Autor: Anna P. Southworth, Gregory J. Baker, Jerrold R. Turner, Karen L. Edelblum, Wangsun Choi, Ma. Lora Drizella M. Ong, Gurminder Singh, Alicia M. Worthylake, Nora E. Joseph, Peter A. Savage, Sam C. Nalle, Li Zuo, Mario C. Manresa

Graft-versus-host disease (GVHD) is a complication of hematopoietic stem cell transplantation (HSCT) that affects multiple organs. GVHD-associated intestinal damage can be separated into two distinct phases, initiation and propagation, which correspo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d1e608626408068b7e93007485e1ceb
https://europepmc.org/articles/PMC6355225/

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The scaffolding protein ZO-1 coordinates actomyosin and epithelial apical specializations

Autor: Matthew A, Odenwald, Wangsun, Choi, Wei-Ting, Kuo, Gurminder, Singh, Anne, Sailer, Yitang, Wang, Le, Shen, Alan S, Fanning, Jerrold R, Turner

Publikováno v: The Journal of biological chemistry. 293(45)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a43d3217f197148133abf9e8a3a41d1f
https://pubmed.ncbi.nlm.nih.gov/30242130

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Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis

Publikováno v: Nature medicine

Epithelial barrier loss is a driver of intestinal and systemic diseases. Myosin light chain kinase (MLCK) is a key effector of barrier dysfunction and a potential therapeutic target, but enzymatic inhibition has unacceptable toxicity. Here, we show t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb50c35847e7eb60dff385c8221d07ee
https://pubmed.ncbi.nlm.nih.gov/30992543

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Contributions of intestinal epithelial barriers to health and disease

Autor: Sunil Yeruva, Jerrold R. Turner, Wangsun Choi

Publikováno v: Experimental cell research. 358(1)

A core function of epithelia is to form barriers that separate tissue compartments within complex organisms. These barriers also separate the internal milieu from the external environment and are, therefore, an essential component of host defense. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c654082ad950280eef601216a4f3a5
https://pubmed.ncbi.nlm.nih.gov/28342899

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Remodeling the zonula adherens in response to tension and the role of afadin in this response

Autor: Alan S. Fanning, Marc-Antoine Fardin, Mark Peifer, Wangsun Choi, René-Marc Mège, Grégoire Peyret, Benoit Ladoux, Alpha S. Yap, Bipul R. Acharya

Publikováno v: Journal of Cell Biology
Journal of Cell Biology, 2016, 213 (2), pp.243-60. ⟨10.1083/jcb.201506115⟩
Journal of Cell Biology, Rockefeller University Press, 2016, 213 (2), pp.243-60. ⟨10.1083/jcb.201506115⟩
The Journal of Cell Biology

During development, epithelial cells must generate and respond to tension without disrupting epithelial barrier function. The authors use superresolution microscopy in MDCK cells to examine how the zonula adherens (ZA) is remodeled in response to ele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3032aed54bf7fdb1bd951bb6c2fb07
https://hal.science/hal-01323924

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ZO-1 interactions with F-actin and occludin direct epithelial polarization and single lumen specification in 3D culture

Autor: Mary M. Buschmann, Yitang Wang, Aaron Buckley, Matthew A. Odenwald, Jeffrey D. Hildebrand, Nora E. Joseph, Alan S. Fanning, Roman Pavlyuk, Nitesh Shashikanth, Wangsun Choi, Jerrold R. Turner, Michael H. Warren, Ben Margolis

Publikováno v: Journal of cell science. 130(1)

Epithelia within tubular organs form and expand lumens. Failure of these processes can result in serious developmental anomalies. Although tight junction assembly is crucial to epithelial polarization, the contribution of specific tight junction prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b344d78182a5f7ace6be985836dade
https://pubmed.ncbi.nlm.nih.gov/27802160

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Platelets from Munc18c heterozygous mice exhibit normal stimulus-induced release

Autor: Jeffery E. Pessin, Wangsun Choi, Todd D. Schraw, Qiansheng Ren, Debbie C. Thurmond, Garland L. Crawford, Sidney W. Whiteheart

Publikováno v: Thrombosis and Haemostasis. 92:829-837

SummaryA critical aspect of hemostasis is the release of clot-forming components from the three intra-platelet stores: dense core granules, α-granules and lysosomes. Exocytosis from these granules is mediated by soluble (SNAPs and NSF) and integralm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d3ffe7a6a737e97cd32f27e0de25df
https://doi.org/10.1160/th04-04-0263

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