Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Wangko Lundström"'
Autor:
Wangko Lundström, Rasmus Gustafsson
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The role for human herpesvirus (HHV)-6A or HHV-6B in multiple sclerosis (MS) pathogenesis has been controversial. Possibly because the damage of the virus infection may occur before onset of clinical symptoms and because it has been difficult to dete
Externí odkaz:
https://doaj.org/article/925f80eb208842cb8c64d0a572e40ec9
Autor:
Wangko Lundström, Rasmus Gustafsson
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The role for human herpesvirus (HHV)-6A or HHV-6B in multiple sclerosis (MS) pathogenesis has been controversial. Possibly because the damage of the virus infection may occur before onset of clinical symptoms and because it has been difficult to dete
Autor:
Anna Glaser, Ingrid Kockum, Ali Manouchehrinia, Katharina Fink, Tomas Olsson, Wangko Lundström, Jan Hillert, Sahl Khalid Bedri
Publikováno v:
Clinical Immunology. 187:15-25
Genetic variants within some cytokine receptor genes have been associated with MS susceptibility, including IL7RA and IL2RA. As these genes are expressed by cells targeted by immune-modulatory drugs, we explored the potential role of their gene produ
Autor:
Ingrid Kockum, Helga Westerlind, C. Smestad, Eva Greiner, Boel Brynedal, Åslaug R. Lorentzen, Frida Lundmark, Jenny Link, Hanne F. Harbo, Wangko Lundström, Jan Hillert, Elisabeth Gulowsen Celius, Thomas Masterman
Publikováno v:
Journal of Neuroimmunology. 237:98-100
Recently, several non-HLA loci have been shown to be convincingly associated with Multiple Sclerosis (MS) susceptibility, assumingly indicating important pathways in the pathogenesis. A genotype influence on disease outcome measures by these genes wo
Autor:
Marie Wahren-Herlenius, Virginija Karrenbauer, Susanna Brauner, Tomas Olsson, Anna Fogdell-Hahn, Christina Hermanrud, Wangko Lundström, Maria Sjöstrand, Jan Hillert
Publikováno v:
Multiple sclerosis (Houndmills, Basingstoke, England). 20(13)
Background: Interleukin-7 (IL-7) is a non-redundant cytokine for T-cell development and survival. The IL-7 signaling pathway has been genetically and functionally associated with several autoimmune diseases including multiple sclerosis (MS). Objectiv
Autor:
Lars Alfredsson, Tomas Olsson, Ingrid Kockum, Elizabeth M. Morse, Crystal L. Mackall, Steven L. Highfill, Wangko Lundström, Jan Hillert, Scott T. R. Walsh, Stephanie Beq
Publikováno v:
Proceedings of the National Academy of Sciences. 110
Human soluble interleukin-7 receptor (sIL7R)α circulates in high molar excess compared with IL-7, but its biology remains unclear. We demonstrate that sIL7Rα has moderate affinity for IL-7 but does not bind thymic stromal lymphopoietin. Functionall
IL-7 plays many essential roles in human health and disease. Congenital deficiencies in IL-7 signaling result in profound immunodeficiency, polymorphisms in IL7Rα modulate susceptibility to autoimmune disease, and acquired somatic activating mutatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe176de09be6cc688057458e2ac728f
https://europepmc.org/articles/PMC3358500/
https://europepmc.org/articles/PMC3358500/
Autor:
Linda Broer, Dirk Goossens, Ben A. Oostra, Cornelia M. van Duijn, A. Dessa Sadovnick, Eva Greiner, Jurgen Del-Favero, Sreeram V. Ramagopalan, Wangko Lundström, Jan Hillert, George C. Ebers, Naghmeh Jafari, I A Hoppenbrouwers, Yurii S. Aulchenko, Jenny Link, Rogier Q. Hintzen, Christine Van Broeckhoven
Publikováno v:
Nature genetics
Nature Genetics, 40(12), 1402-1403. Nature Publishing Group
Nature Genetics, 40(12), 1402-1403. Nature Publishing Group
Rogier Hintzen and colleagues report the results of a search for genetic variants associated with susceptibility to multiple sclerosis in a genetically isolated population that lead to identification of a new susceptibility locus in the region of the
Publikováno v:
Cytokine. 59:551
Introduction IL7R (the gene encoding the IL-7 receptor alpha chain) is associated with susceptibility to various autoimmune conditions including Multiple Sclerosis. We confirm and strengthen previous reports that the MS associated allele ( IL7 R∗C)