Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Wangjian Sheng"'
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
The selective formation of protein bioconjugates under physiological conditions is a challenging task. Here, the authors report that 1,4-dinitroimidazoles are reagents of choice for protein bioconjugation at either cysteine or lysine sites within sho
Externí odkaz:
https://doaj.org/article/c3df2b6ef44148c49531f577004f9225
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Aryl sulfonamides and sultams are important pharmacophores in medicinal chemistry. Here, the authors report a practical palladium-catalyzed C–H activation assisted by amino-acid residues in the substrate leading to arylsulfonamides and bioactive pe
Externí odkaz:
https://doaj.org/article/1164417d0443466dbfc3306107b2bac4
Autor:
Qingqing Chen, Tengfang Long, Jie Zheng, Wangjian Sheng, Shuaishuai Sun, Wei Wei, Jing Zhao, Huan Wang
Publikováno v:
CCS Chemistry. 4:3355-3363
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0465771ba789226645df2544ceef8db7
https://doi.org/10.31635/ccschem.021.202101386
https://doi.org/10.31635/ccschem.021.202101386
Autor:
Chang Zhao, Wangjian Sheng, Ying Wang, Jie Zheng, Xiangqian Xie, Yong Liang, Wanqing Wei, Rui Bao, Huan Wang
Publikováno v:
Nature Chemical Biology. 18:724-732
Lanthipeptides are an important group of natural products with diverse biological functions, and their biosynthesis requires the removal of N-terminal leader peptides (LPs) by designated proteases. LanP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::183781894098abe8097b8663489b434b
https://doi.org/10.1038/s41589-022-01018-2
https://doi.org/10.1038/s41589-022-01018-2
Autor:
Chuangxu Cai, Feifei Wang, Xiuyun Xiao, Wangjian Sheng, Shu Liu, Jun Chen, Jie Zheng, Ran Xie, Zengbing Bai, Huan Wang
Publikováno v:
Chemical Communications. 58:4861-4864
A method is developed for modification and macrocyclization of thiazole-containing peptides through palladium-catalyzed δ-C(sp2)–H olefination.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::478ae95f1c4108016dc08631b8c07a99
https://doi.org/10.1039/d1cc06764h
https://doi.org/10.1039/d1cc06764h
Autor:
Zengbing Bai, Qingqing Chen, Jun Gu, Chuangxu Cai, Jie Zheng, Wangjian Sheng, Shandong Yi, Fang Liu, Huan Wang
Publikováno v:
ACS Catalysis. 11:15125-15134
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::152bbf659ff5a1f23f4b25e58efc5dcc
https://doi.org/10.1021/acscatal.1c05030
https://doi.org/10.1021/acscatal.1c05030
Publikováno v:
Organic Letters. 23:2933-2937
Oxazole is an important pharmacophore and exists in the backbone of many bioactive peptide natural products and peptidomimetics. Efficient methods for the synthesis and direct functionalization of complex oxazole-containing peptides are in high deman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f914c6492fe19636b3c6943fd175784e
https://doi.org/10.1021/acs.orglett.1c00580
https://doi.org/10.1021/acs.orglett.1c00580
Publikováno v:
Angewandte Chemie. 132:14794-14800
Transition-metal-catalyzed C-H activation has shown potential in the functionalization of peptides with expanded structural diversity. Herein, the development of late-stage peptide macrocyclization methods by palladium-catalyzed site-selective C(sp2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d543353a4c7d7c058d730edba6b76aa
https://doi.org/10.1002/ange.202007226
https://doi.org/10.1002/ange.202007226
Publikováno v:
Organic & Biomolecular Chemistry. 18:6095-6099
NAI-112 is a glycosylated class III lanthipeptide produced by an Actinoplanes sp. strain with potent bioactivity against nociceptive pain. It contains two labionin/methyllabionin motifs and a rare deoxyhexose modification N-linked to a tryptophan res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01bb5058d43a887341ab80ad81dbea13
https://doi.org/10.1039/d0ob01215g
https://doi.org/10.1039/d0ob01215g
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Nature Communications
Nature Communications
Peptides and peptidomimetics are emerging as an important class of clinic therapeutics. Here we report a peptide-guided method for the functionalization and macrocyclization of bioactive peptidosulfonamides by Pd(II)-catalyzed late-stage C–H activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2801f095664b325eb880b0c61e8957a4
http://link.springer.com/article/10.1038/s41467-018-05440-w
http://link.springer.com/article/10.1038/s41467-018-05440-w