Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Wange Lu"'
Autor:
Tengfei Shi, Dianhao Guo, Yaoqiang Zheng, Wenbin Wang, Jinfang Bi, Anshun He, Sibo Fan, Guangsong Su, Xueyuan Zhao, Zhenhao Zhao, Yingjie Song, Shupeng Sun, Peng Li, Zhongfang Zhao, Jiandang Shi, Wange Lu, Lei Zhang
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Glioma cell sensitivity to temozolomide (TMZ) is critical for effective treatment and correlates with patient survival, although mechanisms underlying this activity are unclear. Here, we reveal a new mechanism used by glioma cells to modulat
Externí odkaz:
https://doaj.org/article/3968c6b5c3f8445ea4776a806595d274
Autor:
Byoung-San Moon, David Huang, Fan Gao, Mingyang Cai, Guochang Lyu, Lei Zhang, Jun Chen, Wange Lu
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/4d0fd646f7df4f60a880c7351f43492a
Autor:
Zhao Wang, Qian Liang, Xinyi Qian, Bolang Hu, Zhanye Zheng, Jianhua Wang, Yuelin Hu, Zhengkai Bao, Ke Zhao, Yao Zhou, Xiangling Feng, Xianfu Yi, Jin Li, Jiandang Shi, Zhe Liu, Jihui Hao, Kexin Chen, Ying Yu, Pak Chung Sham, Wange Lu, Xiaoyan Wang, Weihong Song, Mulin Jun Li
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Here the authors used an evidence-based strategy to prioritize causal pleiotropic variants of autoimmune diseases, and revealed that rs4728142 modulates aberrant IRF5 alternative promoter usage by ZBTB3-mediated chromatin looping.
Externí odkaz:
https://doaj.org/article/5ffe2bc8274f43c38d73f0ef593fd3ec
Autor:
Byoung-San Moon, David Huang, Fan Gao, Mingyang Cai, Guochang Lyu, Lei Zhang, Jun Chen, Wange Lu
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract Nuclear architecture underlies the transcriptional programs within the cell to establish cell identity. As previously demonstrated, long-range chromatin interactions of the Oct4 distal enhancer (DE) are correlated with active transcription i
Externí odkaz:
https://doaj.org/article/ee96c1692bd0487298c7416fff3bd225
Autor:
Yuyang Qian, Jianhua Wang, Bo Wang, Wenbin Wang, Peng Li, Zhenhao Zhao, Yuan Jiang, He Ren, Dandan Huang, Yang Yang, Zhongfang Zhao, Lei Zhang, Jiandang Shi, Mulin Jun Li, Wange Lu
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106497- (2023)
Summary: To date, genome-wide association studies (GWAS) have revealed over 200 genetic risk loci associated with prostate cancer; yet, true disease-causing variants remain elusive. Identification of causal variants and their targets from association
Externí odkaz:
https://doaj.org/article/bec4d6fa7aef4208bca3f857105ce0bd
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-17 (2022)
Abstract Background Histone cell cycle regulator (HIRA) complex is an important histone chaperone that mediates the deposition of the H3.3 histone variant onto chromatin independently from DNA synthesis. However, it is still unknown whether it partic
Externí odkaz:
https://doaj.org/article/c09fc4e7ee754f7fb45aa3251c2ff5da
Autor:
Tong Zhao, Mingyang Cai, Man Liu, Guangsong Su, Daniel An, Byoungsan Moon, Guochang Lyu, Yibo Si, Lingyi Chen, Wange Lu
Publikováno v:
Stem Cell Reports, Vol 14, Iss 3, Pp 493-505 (2020)
Summary: Both 3D chromatin architecture and long non-coding RNAs (lncRNAs) play essential roles in pluripotency maintenance. However, whether lncRNAs are involved in organizing 3D chromatin structure remains largely unexplored. We identified 39 lncRN
Externí odkaz:
https://doaj.org/article/f6500fadbfe7404ea4d25f2c0c86c811
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-14 (2019)
Abstract Background MMP-9-dependent proteolysis of histone H3 N-terminal tail (H3NT) is an important mechanism for activation of gene expression during osteoclast differentiation. Like other enzymes targeting their substrates within chromatin structu
Externí odkaz:
https://doaj.org/article/b8939718b13144f1be6fd7176e2bf7ff
Autor:
Byoung-San Moon, Aswathy Ammothumkandy, Naibo Zhang, Lei Peng, Albina Ibrayeva, Maxwell Bay, Athira Pratap, Hong Ju Park, Michael Anthony Bonaguidi, Wange Lu
Publikováno v:
Clinical and Experimental Otorhinolaryngology, Vol 11, Iss 4, Pp 224-232 (2018)
Objectives Spiral ganglion neurons (SGNs) include potential endogenous progenitor populations for the regeneration of the peripheral auditory system. However, whether these populations are present in adult mice is largely unknown. We examined the pre
Externí odkaz:
https://doaj.org/article/460cd1da69194b76823ce2e632c8f12a
Autor:
Shaohui Chen, Bohan Chen, Guangsong Su, Jun Chen, Dianhao Guo, Qingqing Yin, Wenbin Wang, Zhongfang Zhao, Lei Zhang, Jiandang Shi, Wange Lu
Publikováno v:
Stem Cell Research, Vol 49, Iss , Pp 102097- (2020)
The developmental plasticity of embryonic stem cells (ESCs) is mainly controlled by well-characterized transcription factors, but additional factors, especially those related to metabolism that modulate this intrinsic program remain elusive. Here, us
Externí odkaz:
https://doaj.org/article/a68f5aadeff446f2903dceea796d47e1