Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Wangcai Gao"'
Autor:
Randy S Daughters, Daniel L Tuttle, Wangcai Gao, Yoshio Ikeda, Melinda L Moseley, Timothy J Ebner, Maurice S Swanson, Laura P W Ranum
Publikováno v:
PLoS Genetics, Vol 5, Iss 8, p e1000600 (2009)
Microsatellite expansions cause a number of dominantly-inherited neurological diseases. Expansions in coding-regions cause protein gain-of-function effects, while non-coding expansions produce toxic RNAs that alter RNA splicing activities of MBNL and
Externí odkaz:
https://doaj.org/article/63cb96186ac94be394aa5608c69b80a5
Autor:
Stacy M Holzbauer, Caroline A Schrodt, Rajesh M Prabhu, Rebecca J Asch-Kendrick, Malia Ireland, Carrie Klumb, Melanie J Firestone, Gongping Liu, Katie Harry, Min Z Levine, Lillian A Orciari, Kimberly Wilkins, James A Ellison, Hui Zhao, Michael Niezgoda, Panayampalli S Satheshkumar, Brett W Petersen, Agam K Rao, W Robert Bell, Sara Forrest, Wangcai Gao, Richard Dasheiff, Kari Russell, Anthony Wiseman, R Ross Reichard, Kirk E Smith, Ruth Lynfield, Joni Scheftel, Ryan M Wallace, Jesse Bonwitt
Publikováno v:
Clinical Infectious Diseases.
Autor:
Stacy M Holzbauer, Caroline A Schrodt, Rajesh M Prabhu, Rebecca J Asch-Kendrick, Malia Ireland, Carrie Klumb, Melanie J Firestone, Gongping Liu, Katie Harry, Jana M Ritter, Min Z Levine, Lillian A Orciari, Kimberly Wilkins, Pamela Yager, Crystal M Gigante, James A Ellison, Hui Zhao, Michael Niezgoda, Yu Li, Robin Levis, Dorothy Scott, Panayampalli S Satheshkumar, Brett W Petersen, Agam K Rao, W Robert Bell, Sonja M Bjerk, Sara Forrest, Wangcai Gao, Richard Dasheiff, Kari Russell, Melissa Pappas, Jessica Kiefer, Wesley Bickler, Anthony Wiseman, Joel Jurantee, R Ross Reichard, Kirk E Smith, Ruth Lynfield, Joni Scheftel, Ryan M Wallace, Jesse Bonwitt
Publikováno v:
Clinical Infectious Diseases.
Background No rabies post-exposure prophylaxis (PEP) failure has been documented in humans in the United States using modern cell-culture vaccines. In January 2021, an 84-year-old male died from rabies six months after being bitten by a rabid bat des
Autor:
Justin A. Barnes, Gang Chen, Blake A. Ebner, Timothy J. Ebner, Harry T. Orr, Lisa A. Duvick, Wangcai Gao
Publikováno v:
The Journal of Neuroscience. 31:12778-12789
One fundamental unanswered question in the field of polyglutamine diseases concerns the pathophysiology of neuronal dysfunction. Is there dysfunction in a specific neuronal population or circuit initially that contributes the onset of behavioral abno
Publikováno v:
Neuroscience. 162:713-722
Long-term potentiation (LTP) of parallel fiber-Purkinje cell (PF-PC) synapses in the cerebellum has been suggested to underlie aspects of motor learning. Previous in vitro studies have primarily used low frequency PF stimulation conditioning paradigm
Publikováno v:
The Journal of Neuroscience. 26:8377-8387
Molecular layer inhibitory interneurons generate on-beam and off-beam inhibition in the cerebellar cortex that is hypothesized to control the timing and/or spatial patterning of Purkinje cell discharge. On- and off-beam inhibition has been assumed to
Autor:
John W. Day, Gang Chen, Laura P.W. Ranum, Marcy R Weatherspoon, Wangcai Gao, Yoshio Ikeda, Anne K Mosemiller, Randy S. Daughters, Timothy J. Ebner, H. Brent Clark, Tao Zu, Melinda L. Moseley
Publikováno v:
Nature Genetics. 38:758-769
We previously reported that a (CTG)n expansion causes spinocerebellar ataxia type 8 (SCA8), a slowly progressive ataxia with reduced penetrance. We now report a transgenic mouse model in which the full-length human SCA8 mutation is transcribed using
Autor:
Wangcai Gao, Kenneth C. Reinert, Gang Chen, Claudia M. Hendrix, Timothy J. Ebner, Laurentiu S. Popa, M. Elizabeth Ross
Publikováno v:
Journal of Neurophysiology. 94:1287-1298
Spreading acidification and depression (SAD) is a form of propagated activity in the cerebellar cortex characterized by acidification and a transient depression in excitability. This study investigated the role of Kv1 potassium channels in SAD using
Publikováno v:
The Journal of Neuroscience. 21:9877-9887
This study investigated the mechanisms underlying the recently reported fast spreading acidification and transient depression in the cerebellar cortexin vivo. Spreading acidification was evoked by surface stimulation in the rat and mouse cerebellar c
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(28)
The role of parallel fibers (PFs) in cerebellar physiology remains controversial. Early studies inspired the “beam” hypothesis whereby granule cell (GC) activation results in PF-driven, postsynaptic excitation of beams of Purkinje cells (PCs). Ho